TY - JOUR T1 - Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract. AU - Zhao,Min, AU - Tao,Jinhua, AU - Qian,Dawei, AU - Liu,Pei, AU - Shang,Er-xin, AU - Jiang,Shu, AU - Guo,Jianming, AU - Su,Shu-lan, AU - Duan,Jin-ao, AU - Du,Leyue, Y1 - 2015/12/14/ PY - 2015/04/17/received PY - 2015/12/02/revised PY - 2015/12/11/accepted PY - 2016/1/1/entrez PY - 2016/1/1/pubmed PY - 2016/8/18/medline KW - Acteoside KW - Catalpol KW - Chronic kidney disease KW - Cornus officinalis KW - Loganin KW - Morroniside KW - Pharmacokinetic study KW - Rehmannia glutinosa KW - UPLC–MS SP - 122 EP - 9 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 1009-1010 N2 - A sensitive and rapid method for determination of loganin, morroniside, catalpol and acteoside in rat plasma after oral administration of Rehmannia glutinosa Libosch and Cornus officinalis Sieb drug pair based on ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS). Chromatographic separation was achieved using an Acquity UPLC BEH C18 column (100mm×2.1mm, 1.7μm) at a flow rate of 0.4mL/min, using gradient mode containing 0.1% formic acid in water and acetonitrile were used as the mobile phase A and B. Loganin, morroniside, catalpol, acteoside and the internal standard (chloramphenicol) were detected by selected reaction monitoring in the negative ion mode with the mass transition of m/z 451.0→179.0 (morroniside), m/z 435.0→227.0 (loganin), m/z 407.1→199.1 (catalpol), m/z 623.2→161.0 (acteoside) and m/z 320.8→151.9 (chloramphenicol), respectively. All calibration curves showed good linearity (r>0.991). The precision was evaluated by intra-day and inter-day assays and the RSD% were all within 9.58%. The recovery ranged from 67.62 to 80.14%. The method was successfully applied to pharmacokinetic study of the analytes in normal and doxorubicin-induced chronic kidney disease rat plasma. SN - 1873-376X UR - https://www.unboundmedicine.com/medline/citation/26720701/Simultaneous_determination_of_loganin_morroniside_catalpol_and_acteoside_in_normal_and_chronic_kidney_disease_rat_plasma_by_UPLC_MS_for_investigating_the_pharmacokinetics_of_Rehmannia_glutinosa_and_Cornus_officinalis_Sieb_drug_pair_extract_ DB - PRIME DP - Unbound Medicine ER -