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[Effects of electroacupuncture on anxiety and sympathetic-adrenal medulla system in rats with insomnia].
Zhongguo Zhen Jiu. 2015 Sep; 35(9):923-6.ZZ

Abstract

OBJECTIVE

To explore the action mechanism of electroacupuncture (EA) at "Shenmen" (HT 7) and "Sanyinjiao" (SP 6) on insomnia.

METHODS

Thirty SD rats were randomly divided into a blank group, a model group and an EA group, 10 cases in each group. The insomnia model was made by immobilization method in the model group and EA group. After model establishment, rats in the blank group and model group were treated with fixation and no treatment was given. Rats in the EA group were treated with EA at "Shenmen" (HT 7) and "San-yinjiao" (SP 6) for 15 min, once a day for 4 days. After treatment, the level of daytime and nighttime activity, open-arm entry percentage and open-arm time percentage of elevated plus-maze test were measured; the content of noradrenaline (NE), dopamine (DA) and epinephrine (EPI) in plasma and NE, DA in thalamus and brainstem were detected by using euzymelinked immunosorbent assay method.

RESULTS

Compared with the blank group, the daytime activity was increased and nighttime activity was reduced in the model group (both P<0. 05); the open-arm entry percentage and open-arm time percentage of elevated plus-maze test were both reduced in the model group (both P<0. 05); the contents of NE, DA, EPI in the plasma and NE, DA in thalamus and brainstem were increased in the model group (all P<0. 05). Compared with the model group, the daytime activity was reduced and nighttime activity was increased in the EA group (both P<0. 05); the open-arm entry percentage and open-arm time percentage of elevated plus-maze test were both increased in the EA group (both P<0. 05); the contents of NE, DA, EPI in the plasma and NE, DA in thalamus and brainstem were reduced in the EA group (all P< 0. 05).

CONCLUSION

Electroacupuncture at "Shenmen" (HT 7) and "Sanyinjiao" (SP 6) can restrain the over-activity of the sympathetic-adrenal medullary system to treat the insomnia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

26721150

Citation

Cheng, Cisong, et al. "[Effects of Electroacupuncture On Anxiety and Sympathetic-adrenal Medulla System in Rats With Insomnia]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 35, no. 9, 2015, pp. 923-6.
Cheng C, Liu P, Wu Q, et al. [Effects of electroacupuncture on anxiety and sympathetic-adrenal medulla system in rats with insomnia]. Zhongguo Zhen Jiu. 2015;35(9):923-6.
Cheng, C., Liu, P., Wu, Q., Zhong, Z., Kou, J., Wen, P., & Zhu, Y. (2015). [Effects of electroacupuncture on anxiety and sympathetic-adrenal medulla system in rats with insomnia]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 35(9), 923-6.
Cheng C, et al. [Effects of Electroacupuncture On Anxiety and Sympathetic-adrenal Medulla System in Rats With Insomnia]. Zhongguo Zhen Jiu. 2015;35(9):923-6. PubMed PMID: 26721150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of electroacupuncture on anxiety and sympathetic-adrenal medulla system in rats with insomnia]. AU - Cheng,Cisong, AU - Liu,Ping, AU - Wu,Qiwen, AU - Zhong,Zhendong, AU - Kou,Jun, AU - Wen,Peipei, AU - Zhu,Yihui, PY - 2016/1/2/entrez PY - 2016/1/2/pubmed PY - 2016/2/10/medline SP - 923 EP - 6 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 35 IS - 9 N2 - OBJECTIVE: To explore the action mechanism of electroacupuncture (EA) at "Shenmen" (HT 7) and "Sanyinjiao" (SP 6) on insomnia. METHODS: Thirty SD rats were randomly divided into a blank group, a model group and an EA group, 10 cases in each group. The insomnia model was made by immobilization method in the model group and EA group. After model establishment, rats in the blank group and model group were treated with fixation and no treatment was given. Rats in the EA group were treated with EA at "Shenmen" (HT 7) and "San-yinjiao" (SP 6) for 15 min, once a day for 4 days. After treatment, the level of daytime and nighttime activity, open-arm entry percentage and open-arm time percentage of elevated plus-maze test were measured; the content of noradrenaline (NE), dopamine (DA) and epinephrine (EPI) in plasma and NE, DA in thalamus and brainstem were detected by using euzymelinked immunosorbent assay method. RESULTS: Compared with the blank group, the daytime activity was increased and nighttime activity was reduced in the model group (both P<0. 05); the open-arm entry percentage and open-arm time percentage of elevated plus-maze test were both reduced in the model group (both P<0. 05); the contents of NE, DA, EPI in the plasma and NE, DA in thalamus and brainstem were increased in the model group (all P<0. 05). Compared with the model group, the daytime activity was reduced and nighttime activity was increased in the EA group (both P<0. 05); the open-arm entry percentage and open-arm time percentage of elevated plus-maze test were both increased in the EA group (both P<0. 05); the contents of NE, DA, EPI in the plasma and NE, DA in thalamus and brainstem were reduced in the EA group (all P< 0. 05). CONCLUSION: Electroacupuncture at "Shenmen" (HT 7) and "Sanyinjiao" (SP 6) can restrain the over-activity of the sympathetic-adrenal medullary system to treat the insomnia. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/26721150/[Effects_of_electroacupuncture_on_anxiety_and_sympathetic_adrenal_medulla_system_in_rats_with_insomnia]_ L2 - http://www.diseaseinfosearch.org/result/7698 DB - PRIME DP - Unbound Medicine ER -