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Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases with Breast Cancer.
Anticancer Res. 2016 Jan; 36(1):393-7.AR

Abstract

In order to evaluate affected axillary lymph nodes in breast cancer by positron-emission tomography using (18)F-fluorodeoxyglucose (FDG-PET), an understanding of FDG avidity is important. In the present study, we examined whether certain factors, including lymphatic spread and size of metastatic lymph nodes, were associated with FDG avidity in order to evaluate the benefits of a FDG-PET assessment of axillary node metastases. We retrospectively investigated the cases of 179 consecutive patients with primary breast cancer who underwent FDG-PET preoperatively. Among the 179 patients, 48 (26.8%) had axillary lymph node metastases. The sensitivity, specificity, overall accuracy, and false-negative rates in the diagnosis of axillary lymph node status by FDG-PET were 47.9%, 98.5%, 84.9%, and 52.1%, respectively. The 48 cases with lymph node metastases were divided into two groups based on the presence or not of FDG uptake in the axillary lesions. Clinicopathological features of the primary tumor, including tumor size, standardized uptake value (SUVmax and biomarkers, were not statistically significant factors; only the clinicopathological features of metastatic lymph nodes, including the size of node metastasis, were significantly associated with FDG uptake in the axillary lymph nodes. Among the eight cases of micrometastasis, seven were not detected by FDG-PET. The number of cases with only one affected node was significantly higher in the group without FDG uptake in the axillary lesion. Although the number of lymph node metastases was relatively higher in the FDG-PET-positive patients, the difference was not statistically significant. FDG-PET may help identify patients with high axillary lymph node burden. Our findings imply that preoperative FDG-PET evaluation of lymph nodes is not sufficient to predict lymphatic spread or micrometastasis because FDG avidity is mainly influenced by the size of the tumor.

Authors+Show Affiliations

Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan ftakaaki@gunma-u.ac.jp.Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26722071

Citation

Fujii, Takaaki, et al. "Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases With Breast Cancer." Anticancer Research, vol. 36, no. 1, 2016, pp. 393-7.
Fujii T, Yajima R, Tatsuki H, et al. Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases with Breast Cancer. Anticancer Res. 2016;36(1):393-7.
Fujii, T., Yajima, R., Tatsuki, H., Oosone, K., & Kuwano, H. (2016). Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases with Breast Cancer. Anticancer Research, 36(1), 393-7.
Fujii T, et al. Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases With Breast Cancer. Anticancer Res. 2016;36(1):393-7. PubMed PMID: 26722071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implication of ¹⁸F-Fluorodeoxyglucose Uptake of Affected Axillary Lymph Nodes in Cases with Breast Cancer. AU - Fujii,Takaaki, AU - Yajima,Reina, AU - Tatsuki,Hironori, AU - Oosone,Katsuya, AU - Kuwano,Hiroyuki, PY - 2016/1/2/entrez PY - 2016/1/2/pubmed PY - 2016/5/14/medline KW - FDG avidity KW - FDG-PET KW - Lymph node metastasis KW - breast cancer KW - lymphatic spread KW - size SP - 393 EP - 7 JF - Anticancer research JO - Anticancer Res VL - 36 IS - 1 N2 - In order to evaluate affected axillary lymph nodes in breast cancer by positron-emission tomography using (18)F-fluorodeoxyglucose (FDG-PET), an understanding of FDG avidity is important. In the present study, we examined whether certain factors, including lymphatic spread and size of metastatic lymph nodes, were associated with FDG avidity in order to evaluate the benefits of a FDG-PET assessment of axillary node metastases. We retrospectively investigated the cases of 179 consecutive patients with primary breast cancer who underwent FDG-PET preoperatively. Among the 179 patients, 48 (26.8%) had axillary lymph node metastases. The sensitivity, specificity, overall accuracy, and false-negative rates in the diagnosis of axillary lymph node status by FDG-PET were 47.9%, 98.5%, 84.9%, and 52.1%, respectively. The 48 cases with lymph node metastases were divided into two groups based on the presence or not of FDG uptake in the axillary lesions. Clinicopathological features of the primary tumor, including tumor size, standardized uptake value (SUVmax and biomarkers, were not statistically significant factors; only the clinicopathological features of metastatic lymph nodes, including the size of node metastasis, were significantly associated with FDG uptake in the axillary lymph nodes. Among the eight cases of micrometastasis, seven were not detected by FDG-PET. The number of cases with only one affected node was significantly higher in the group without FDG uptake in the axillary lesion. Although the number of lymph node metastases was relatively higher in the FDG-PET-positive patients, the difference was not statistically significant. FDG-PET may help identify patients with high axillary lymph node burden. Our findings imply that preoperative FDG-PET evaluation of lymph nodes is not sufficient to predict lymphatic spread or micrometastasis because FDG avidity is mainly influenced by the size of the tumor. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/26722071/Implication_of_¹⁸F_Fluorodeoxyglucose_Uptake_of_Affected_Axillary_Lymph_Nodes_in_Cases_with_Breast_Cancer_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=26722071 DB - PRIME DP - Unbound Medicine ER -