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An autopsy case of methanol induced intracranial hemorrhage.
Int J Clin Exp Pathol. 2015; 8(10):13643-6.IJ

Abstract

The major component of car washer fluid is a methanol. Intracranial hemorrhage is a rare but lethal complication in methanol poisoning. We report a case of massive bilateral basal ganglia hematoma in a 32-year-old man with methanol poisoning. He drank car washer solution twice time (about 500 ml), and was admitted to a territorial hospital 10 hours post-ingestion for depressed mental status, lower blood pressure, and high anion gap metabolic acidosis. Computed tomographic (CT) scan showed lesions in both putamen and cerebral deep white matter. Twenty-one days after methanol exposure, he suddenly developed cardiorespiratory arrest. In autopsy, external examination revealed moderate cerebral edema, but no evidence of herniation. Coronal sections of the brain showed softening and about 34 g hematoma in the bilateral putamen and 3rd ventricles. The toxic effect of methanol on the visual system has been noted in the absence of neurologic manifestations; however, there have also been a report of concomitant brain in Korea.

Authors+Show Affiliations

Department of Forensic Medicine, Chonnam National University Medical School Gwangju, Korea ; Department of Pathology, Saint Carollo Hospital Sun-Cheon, Chonnam, Korea.Division of Forensic Medicine, National Forensic Service Jangseong-Gun, Jeollanam-do, Korea.Department of Pathology, Saint Carollo Hospital Sun-Cheon, Chonnam, Korea.Department of Forensic Medicine, Chonnam National University Medical School Gwangju, Korea.Department of Forensic Medicine, Chonnam National University Medical School Gwangju, Korea.

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26722590

Citation

Kim, Hye-Jeong, et al. "An Autopsy Case of Methanol Induced Intracranial Hemorrhage." International Journal of Clinical and Experimental Pathology, vol. 8, no. 10, 2015, pp. 13643-6.
Kim HJ, Na JY, Lee YJ, et al. An autopsy case of methanol induced intracranial hemorrhage. Int J Clin Exp Pathol. 2015;8(10):13643-6.
Kim, H. J., Na, J. Y., Lee, Y. J., Park, J. T., & Kim, H. S. (2015). An autopsy case of methanol induced intracranial hemorrhage. International Journal of Clinical and Experimental Pathology, 8(10), 13643-6.
Kim HJ, et al. An Autopsy Case of Methanol Induced Intracranial Hemorrhage. Int J Clin Exp Pathol. 2015;8(10):13643-6. PubMed PMID: 26722590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An autopsy case of methanol induced intracranial hemorrhage. AU - Kim,Hye-Jeong, AU - Na,Joo-Young, AU - Lee,Young-Jik, AU - Park,Jong-Tae, AU - Kim,Hyung-Seok, Y1 - 2015/10/01/ PY - 2015/08/16/received PY - 2015/09/23/accepted PY - 2016/1/2/entrez PY - 2016/1/2/pubmed PY - 2016/12/15/medline KW - Methanol poisoning KW - autopsy KW - car washer fluid KW - intoxication KW - intracranial hemorrhage SP - 13643 EP - 6 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 8 IS - 10 N2 - The major component of car washer fluid is a methanol. Intracranial hemorrhage is a rare but lethal complication in methanol poisoning. We report a case of massive bilateral basal ganglia hematoma in a 32-year-old man with methanol poisoning. He drank car washer solution twice time (about 500 ml), and was admitted to a territorial hospital 10 hours post-ingestion for depressed mental status, lower blood pressure, and high anion gap metabolic acidosis. Computed tomographic (CT) scan showed lesions in both putamen and cerebral deep white matter. Twenty-one days after methanol exposure, he suddenly developed cardiorespiratory arrest. In autopsy, external examination revealed moderate cerebral edema, but no evidence of herniation. Coronal sections of the brain showed softening and about 34 g hematoma in the bilateral putamen and 3rd ventricles. The toxic effect of methanol on the visual system has been noted in the absence of neurologic manifestations; however, there have also been a report of concomitant brain in Korea. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/26722590/An_autopsy_case_of_methanol_induced_intracranial_hemorrhage_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26722590/ DB - PRIME DP - Unbound Medicine ER -