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Hepatitis E, the neglected one.
Liver Int. 2016 Jan; 36 Suppl 1:130-4.LI

Abstract

Hepatitis E virus (HEV) infection is a worldwide disease. It is the first cause of acute viral hepatitis in the world with an estimated 20 million cases every year and 56 000 deaths. In developing countries, hepatitis E is a waterborne infection. In these countries, HEV genotypes 1 and 2 cause large outbreaks and affect young subjects with a significant mortality rate in pregnant women and patients with cirrhosis. In the developed countries, HEV genotypes 3 and 4 are responsible for autochthonous, sporadic hepatitis and transmission is zoonotic. HEV can cause neurological disorders and in immunocompromised patients, chronic infections. The progression of acute hepatitis E is most often mild and resolves spontaneously. Diagnostic tools include anti-HEV IgM antibodies in serum and/or viral RNA in the blood or stools by PCR. Ribavirin is used to treat chronic infection. A vaccine has been developed in China.

Authors+Show Affiliations

Service d'hépato-Gastro-Entérologie, Hôpital Purpan CHU Toulouse, Université Paul Sabatier III, Toulouse, France.Laboratoire de Virologie, Hôpital Purpan CHU Toulouse, Université Paul Sabatier III, Toulouse, France.Unité INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaire, Université Paul Sabatier III, Toulouse, France.Service d'hépato-Gastro-Entérologie, Hôpital Purpan CHU Toulouse, Université Paul Sabatier III, Toulouse, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26725910

Citation

Blasco-Perrin, Hélène, et al. "Hepatitis E, the Neglected One." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 36 Suppl 1, 2016, pp. 130-4.
Blasco-Perrin H, Abravanel F, Blasco-Baque V, et al. Hepatitis E, the neglected one. Liver Int. 2016;36 Suppl 1:130-4.
Blasco-Perrin, H., Abravanel, F., Blasco-Baque, V., & Péron, J. M. (2016). Hepatitis E, the neglected one. Liver International : Official Journal of the International Association for the Study of the Liver, 36 Suppl 1, 130-4. https://doi.org/10.1111/liv.13014
Blasco-Perrin H, et al. Hepatitis E, the Neglected One. Liver Int. 2016;36 Suppl 1:130-4. PubMed PMID: 26725910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E, the neglected one. AU - Blasco-Perrin,Hélène, AU - Abravanel,Florence, AU - Blasco-Baque,Vincent, AU - Péron,Jean Marie, PY - 2015/11/10/received PY - 2015/11/10/accepted PY - 2016/1/5/entrez PY - 2016/1/5/pubmed PY - 2016/10/8/medline KW - acute viral hepatitis KW - chronic hepatitis KW - hepatitis E virus KW - neurological symptoms KW - ribavirin KW - zoonosis SP - 130 EP - 4 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 36 Suppl 1 N2 - Hepatitis E virus (HEV) infection is a worldwide disease. It is the first cause of acute viral hepatitis in the world with an estimated 20 million cases every year and 56 000 deaths. In developing countries, hepatitis E is a waterborne infection. In these countries, HEV genotypes 1 and 2 cause large outbreaks and affect young subjects with a significant mortality rate in pregnant women and patients with cirrhosis. In the developed countries, HEV genotypes 3 and 4 are responsible for autochthonous, sporadic hepatitis and transmission is zoonotic. HEV can cause neurological disorders and in immunocompromised patients, chronic infections. The progression of acute hepatitis E is most often mild and resolves spontaneously. Diagnostic tools include anti-HEV IgM antibodies in serum and/or viral RNA in the blood or stools by PCR. Ribavirin is used to treat chronic infection. A vaccine has been developed in China. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/26725910/Hepatitis_E_the_neglected_one_ L2 - https://doi.org/10.1111/liv.13014 DB - PRIME DP - Unbound Medicine ER -