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Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.

Abstract

Arthritis causes disability due to pain and inflammation in joints. There are many forms of arthritis, one of which is osteoarthritis whose prevalence increases with age. It occurs in various joints including hip, knee and hand with knee osteoarthritis being more prevalent. There is no cure for it. The management strategies include exercise, glucosamine plus chondroitin sulfate and NSAIDs. In vitro and animal studies provide a rationale for the use of antioxidant supplements for its management. This review assesses the reality of the benefits of antioxidant supplements in the management of knee osteoarthritis. Several difficulties were encountered in examining this issue: poorly conducted studies, a lack of uniformity in disease definition and diagnosis, and muddling of conclusions from attempts to isolate the efficacious molecules. The antioxidant supplements with most evidence for benefit for pain relief and function in knee osteoarthritis were based on curcumin and avocado-soya bean unsaponifiables. Boswellia and some herbs used in Ayurvedic and Chinese medicine may also be useful. The benefits of cuisines with the appropriate antioxidants should be assessed because they may be more economical and easier to incorporate into the lifestyle.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, HSC 4N41, McMaster University, 1280 Main Street W., Hamilton, ON, L8S 4K1, Canada. groverak@mcmaster.ca.

    Department of Medicine, HSC 4N41, McMaster University, 1280 Main Street W., Hamilton, ON, L8S 4K1, Canada.

    Source

    Nutrition journal 15: 2016 Jan 05 pg 1

    MeSH

    Anti-Inflammatory Agents, Non-Steroidal
    Antioxidants
    Boswellia
    Curcuma
    Dietary Supplements
    Humans
    Medicine, Ayurvedic
    Medicine, Chinese Traditional
    Osteoarthritis, Knee
    Persea
    Randomized Controlled Trials as Topic
    Reactive Oxygen Species
    Soybeans

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26728196

    Citation

    Grover, Ashok Kumar, and Sue E. Samson. "Benefits of Antioxidant Supplements for Knee Osteoarthritis: Rationale and Reality." Nutrition Journal, vol. 15, 2016, p. 1.
    Grover AK, Samson SE. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. Nutr J. 2016;15:1.
    Grover, A. K., & Samson, S. E. (2016). Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. Nutrition Journal, 15, p. 1. doi:10.1186/s12937-015-0115-z.
    Grover AK, Samson SE. Benefits of Antioxidant Supplements for Knee Osteoarthritis: Rationale and Reality. Nutr J. 2016 Jan 5;15:1. PubMed PMID: 26728196.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. AU - Grover,Ashok Kumar, AU - Samson,Sue E, Y1 - 2016/01/05/ PY - 2015/08/28/received PY - 2015/12/21/accepted PY - 2016/1/6/entrez PY - 2016/1/6/pubmed PY - 2016/10/21/medline SP - 1 EP - 1 JF - Nutrition journal JO - Nutr J VL - 15 N2 - Arthritis causes disability due to pain and inflammation in joints. There are many forms of arthritis, one of which is osteoarthritis whose prevalence increases with age. It occurs in various joints including hip, knee and hand with knee osteoarthritis being more prevalent. There is no cure for it. The management strategies include exercise, glucosamine plus chondroitin sulfate and NSAIDs. In vitro and animal studies provide a rationale for the use of antioxidant supplements for its management. This review assesses the reality of the benefits of antioxidant supplements in the management of knee osteoarthritis. Several difficulties were encountered in examining this issue: poorly conducted studies, a lack of uniformity in disease definition and diagnosis, and muddling of conclusions from attempts to isolate the efficacious molecules. The antioxidant supplements with most evidence for benefit for pain relief and function in knee osteoarthritis were based on curcumin and avocado-soya bean unsaponifiables. Boswellia and some herbs used in Ayurvedic and Chinese medicine may also be useful. The benefits of cuisines with the appropriate antioxidants should be assessed because they may be more economical and easier to incorporate into the lifestyle. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/26728196/full_citation L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-015-0115-z DB - PRIME DP - Unbound Medicine ER -