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Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women.

Abstract

In a cross-sectional analysis, we evaluated the associations of usual total alcohol and wine intake with a comprehensive profile of mid-luteal phase urinary estrogens and estrogen metabolites (referred to jointly as EM) in a sample of 603 premenopausal women participating in the Nurses' Health Study II (NHSII). A total of 15 individual EM (pmol/mg creatinine) were measured by a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method with high accuracy and reproducibility. We used linear mixed models to calculate the adjusted geometric means of individual EM, EM grouped by metabolic pathways, and pathway ratios by category of alcohol intake with non-drinkers of alcohol as the referent. Total alcohol intake was not associated with total EM but was positively associated with estradiol (26% higher among women consuming >15 g/day vs. non-drinkers; P trend = 0.03). Wine consumption was positively associated with a number of EM measures including estradiol (22% higher among women consuming ≥ 5 drinks/week vs. non-drinkers, P trend < 0.0001). In conclusion, the total alcohol intake was positively and significantly associated with urinary estradiol levels. Some differences in urinary estrogen metabolites were observed with wine drinking, when compared with non-drinkers. This study strengthens the evidence that alcohol consumption might play a role in breast cancer and other estrogen-related conditions. Additional studies of premenopausal women are needed to further explore the association of alcohol, particularly the specific types of alcohol, on patterns of estrogen metabolism in blood, urine, and tissue.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Rollins School of Public Health & Winship Cancer Institute, Emory University, 1518 Clifton Road NE, CNR #3035, Atlanta, GA, 30322, USA. tjhartm@emory.edu.

    ,

    Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

    ,

    Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.

    ,

    Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

    ,

    Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

    Source

    Hormones & cancer 7:1 2016 Feb pg 65-74

    MeSH

    Adult
    Alcohol Drinking
    Cross-Sectional Studies
    Estradiol
    Estrogens
    Female
    Humans
    Linear Models
    Luteal Phase
    Metabolic Networks and Pathways
    Premenopause

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    26728472

    Citation

    Hartman, Terryl J., et al. "Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women." Hormones & Cancer, vol. 7, no. 1, 2016, pp. 65-74.
    Hartman TJ, Sisti JS, Hankinson SE, et al. Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women. Horm Cancer. 2016;7(1):65-74.
    Hartman, T. J., Sisti, J. S., Hankinson, S. E., Xu, X., Eliassen, A. H., & Ziegler, R. (2016). Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women. Hormones & Cancer, 7(1), pp. 65-74. doi:10.1007/s12672-015-0249-7.
    Hartman TJ, et al. Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women. Horm Cancer. 2016;7(1):65-74. PubMed PMID: 26728472.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol Consumption and Urinary Estrogens and Estrogen Metabolites in Premenopausal Women. AU - Hartman,Terryl J, AU - Sisti,Julia S, AU - Hankinson,Susan E, AU - Xu,Xia, AU - Eliassen,A Heather, AU - Ziegler,Regina, Y1 - 2016/01/04/ PY - 2015/10/13/received PY - 2015/12/16/accepted PY - 2016/1/6/entrez PY - 2016/1/6/pubmed PY - 2016/11/7/medline SP - 65 EP - 74 JF - Hormones & cancer JO - Horm Cancer VL - 7 IS - 1 N2 - In a cross-sectional analysis, we evaluated the associations of usual total alcohol and wine intake with a comprehensive profile of mid-luteal phase urinary estrogens and estrogen metabolites (referred to jointly as EM) in a sample of 603 premenopausal women participating in the Nurses' Health Study II (NHSII). A total of 15 individual EM (pmol/mg creatinine) were measured by a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method with high accuracy and reproducibility. We used linear mixed models to calculate the adjusted geometric means of individual EM, EM grouped by metabolic pathways, and pathway ratios by category of alcohol intake with non-drinkers of alcohol as the referent. Total alcohol intake was not associated with total EM but was positively associated with estradiol (26% higher among women consuming >15 g/day vs. non-drinkers; P trend = 0.03). Wine consumption was positively associated with a number of EM measures including estradiol (22% higher among women consuming ≥ 5 drinks/week vs. non-drinkers, P trend < 0.0001). In conclusion, the total alcohol intake was positively and significantly associated with urinary estradiol levels. Some differences in urinary estrogen metabolites were observed with wine drinking, when compared with non-drinkers. This study strengthens the evidence that alcohol consumption might play a role in breast cancer and other estrogen-related conditions. Additional studies of premenopausal women are needed to further explore the association of alcohol, particularly the specific types of alcohol, on patterns of estrogen metabolism in blood, urine, and tissue. SN - 1868-8500 UR - https://www.unboundmedicine.com/medline/citation/26728472/Alcohol_Consumption_and_Urinary_Estrogens_and_Estrogen_Metabolites_in_Premenopausal_Women_ L2 - https://dx.doi.org/10.1007/s12672-015-0249-7 DB - PRIME DP - Unbound Medicine ER -