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Numerical simulation of transient dynamic behavior of healthy and hardened red blood cells in microcapillary flow.

Abstract

In a number of human diseases such as diabetes mellitus and sickle cell anemia, variations in mechanical properties of red blood cells (RBCs) occur and cause reduced deformability. Investigating the behavior of such abnormal, hardened RBCs in microcapillary flow is of prime importance because of their effects on oxygen transport process. In the present paper, dynamic response of a RBC to a microcapillary flow is numerically studied at steady and transient conditions, considering the effect of essential parameters including RBC deformability, its initial orientation, velocity, and flow pressure gradient. Simulations are performed using a three-dimensional hybrid method, combining lattice Boltzmann method for plasma flow, finite element method for RBC membrane analysis, and immersed boundary method for their interaction. Quantitative and qualitative validations with the experimental data for different RBC velocities verify the accuracy of applied numerical method. Apart from the initial orientation, RBC experiences a complex shape deformation in which the biconcave discoid shape changes to a parachute-like shape. While deformation index of RBC does not change considerably with RBC deformability at steady state condition, it plays an important role in its shape evolution under transient condition. Copyright © 2016 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Department of Mechanical Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran. z.hashemi@eng.uk.ac.ir, z.hashemi986@gmail.com.Department of Mechanical Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26729644

Citation

Hashemi, Z, and M Rahnama. "Numerical Simulation of Transient Dynamic Behavior of Healthy and Hardened Red Blood Cells in Microcapillary Flow." International Journal for Numerical Methods in Biomedical Engineering, vol. 32, no. 11, 2016.
Hashemi Z, Rahnama M. Numerical simulation of transient dynamic behavior of healthy and hardened red blood cells in microcapillary flow. Int J Numer Method Biomed Eng. 2016;32(11).
Hashemi, Z., & Rahnama, M. (2016). Numerical simulation of transient dynamic behavior of healthy and hardened red blood cells in microcapillary flow. International Journal for Numerical Methods in Biomedical Engineering, 32(11), doi:10.1002/cnm.2763.
Hashemi Z, Rahnama M. Numerical Simulation of Transient Dynamic Behavior of Healthy and Hardened Red Blood Cells in Microcapillary Flow. Int J Numer Method Biomed Eng. 2016;32(11) PubMed PMID: 26729644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Numerical simulation of transient dynamic behavior of healthy and hardened red blood cells in microcapillary flow. AU - Hashemi,Z, AU - Rahnama,M, Y1 - 2016/01/20/ PY - 2015/08/10/received PY - 2015/12/13/revised PY - 2015/12/28/accepted PY - 2016/11/3/pubmed PY - 2017/7/28/medline PY - 2016/1/6/entrez KW - 3-D numerical simulation KW - RBC deformability KW - RBC deformation KW - microcapillary flow JF - International journal for numerical methods in biomedical engineering JO - Int J Numer Method Biomed Eng VL - 32 IS - 11 N2 - In a number of human diseases such as diabetes mellitus and sickle cell anemia, variations in mechanical properties of red blood cells (RBCs) occur and cause reduced deformability. Investigating the behavior of such abnormal, hardened RBCs in microcapillary flow is of prime importance because of their effects on oxygen transport process. In the present paper, dynamic response of a RBC to a microcapillary flow is numerically studied at steady and transient conditions, considering the effect of essential parameters including RBC deformability, its initial orientation, velocity, and flow pressure gradient. Simulations are performed using a three-dimensional hybrid method, combining lattice Boltzmann method for plasma flow, finite element method for RBC membrane analysis, and immersed boundary method for their interaction. Quantitative and qualitative validations with the experimental data for different RBC velocities verify the accuracy of applied numerical method. Apart from the initial orientation, RBC experiences a complex shape deformation in which the biconcave discoid shape changes to a parachute-like shape. While deformation index of RBC does not change considerably with RBC deformability at steady state condition, it plays an important role in its shape evolution under transient condition. Copyright © 2016 John Wiley & Sons, Ltd. SN - 2040-7947 UR - https://www.unboundmedicine.com/medline/citation/26729644/Numerical_simulation_of_transient_dynamic_behavior_of_healthy_and_hardened_red_blood_cells_in_microcapillary_flow_ L2 - https://doi.org/10.1002/cnm.2763 DB - PRIME DP - Unbound Medicine ER -