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Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis.
Biochim Biophys Acta. 2016 Mar; 1861(3):227-38.BB

Abstract

The natural food for Atlantic salmon (Salmo salar) in freshwater has relatively lower levels of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) than found in prey for post-smolt salmon in seawater. Land-locked salmon such as the Gullspång population feed exclusively on freshwater type lipids during its entire life cycle, a successful adaptation derived from divergent evolution. Studying land-locked populations may provide insights into the molecular and genetic control mechanisms that determine and regulate n-3 LC-PUFA biosynthesis and retention in Atlantic salmon. A two factorial study was performed comparing land-locked and farmed salmon parr fed diets formulated with fish or rapeseed oil for 8 weeks. The land-locked parr had higher capacity to synthesise n-3 LC-PUFA as indicated by higher expression and activity of desaturase and elongase enzymes. The data suggested that the land-locked salmon had reduced sensitivity to dietary fatty acid composition and that dietary docosahexaenoic acid (DHA) did not appear to suppress expression of LC-PUFA biosynthetic genes or activity of the biosynthesis pathway, probably an evolutionary adaptation to a natural diet lower in DHA. Increased biosynthetic activity did not translate to enhanced n-3 LC-PUFA contents in the flesh and diet was the only factor affecting this parameter. Additionally, high lipogenic and glycolytic potentials were found in land-locked salmon, together with decreased lipolysis which in turn could indicate increased use of carbohydrates as an energy source and a sparing of lipid.

Authors+Show Affiliations

Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK. Electronic address: m.b.betancor@stir.ac.uk.Institute of Marine Research, Matre 5984, Matredal, Norway; Norwegian University of Science and Technology, Department of Biology, 7491 Trondheim, Norway.Institute of Marine Research, Matre 5984, Matredal, Norway.Institute of Marine Research, Matre 5984, Matredal, Norway.Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26732752

Citation

Betancor, M B., et al. "Assessment of a Land-locked Atlantic Salmon (Salmo Salar L.) Population as a Potential Genetic Resource With a Focus On Long-chain Polyunsaturated Fatty Acid Biosynthesis." Biochimica Et Biophysica Acta, vol. 1861, no. 3, 2016, pp. 227-38.
Betancor MB, Olsen RE, Solstorm D, et al. Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis. Biochim Biophys Acta. 2016;1861(3):227-38.
Betancor, M. B., Olsen, R. E., Solstorm, D., Skulstad, O. F., & Tocher, D. R. (2016). Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis. Biochimica Et Biophysica Acta, 1861(3), 227-38. https://doi.org/10.1016/j.bbalip.2015.12.015
Betancor MB, et al. Assessment of a Land-locked Atlantic Salmon (Salmo Salar L.) Population as a Potential Genetic Resource With a Focus On Long-chain Polyunsaturated Fatty Acid Biosynthesis. Biochim Biophys Acta. 2016;1861(3):227-38. PubMed PMID: 26732752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of a land-locked Atlantic salmon (Salmo salar L.) population as a potential genetic resource with a focus on long-chain polyunsaturated fatty acid biosynthesis. AU - Betancor,M B, AU - Olsen,R E, AU - Solstorm,D, AU - Skulstad,O F, AU - Tocher,D R, Y1 - 2015/12/28/ PY - 2015/09/23/received PY - 2015/12/15/revised PY - 2015/12/18/accepted PY - 2016/1/7/entrez PY - 2016/1/7/pubmed PY - 2016/6/9/medline KW - Atlantic salmon KW - Desaturases KW - Elongases KW - Land-locked KW - Omega−3 long chain polyunsaturated fatty acids SP - 227 EP - 38 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1861 IS - 3 N2 - The natural food for Atlantic salmon (Salmo salar) in freshwater has relatively lower levels of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) than found in prey for post-smolt salmon in seawater. Land-locked salmon such as the Gullspång population feed exclusively on freshwater type lipids during its entire life cycle, a successful adaptation derived from divergent evolution. Studying land-locked populations may provide insights into the molecular and genetic control mechanisms that determine and regulate n-3 LC-PUFA biosynthesis and retention in Atlantic salmon. A two factorial study was performed comparing land-locked and farmed salmon parr fed diets formulated with fish or rapeseed oil for 8 weeks. The land-locked parr had higher capacity to synthesise n-3 LC-PUFA as indicated by higher expression and activity of desaturase and elongase enzymes. The data suggested that the land-locked salmon had reduced sensitivity to dietary fatty acid composition and that dietary docosahexaenoic acid (DHA) did not appear to suppress expression of LC-PUFA biosynthetic genes or activity of the biosynthesis pathway, probably an evolutionary adaptation to a natural diet lower in DHA. Increased biosynthetic activity did not translate to enhanced n-3 LC-PUFA contents in the flesh and diet was the only factor affecting this parameter. Additionally, high lipogenic and glycolytic potentials were found in land-locked salmon, together with decreased lipolysis which in turn could indicate increased use of carbohydrates as an energy source and a sparing of lipid. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26732752/Assessment_of_a_land_locked_Atlantic_salmon__Salmo_salar_L___population_as_a_potential_genetic_resource_with_a_focus_on_long_chain_polyunsaturated_fatty_acid_biosynthesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-1981(15)00237-1 DB - PRIME DP - Unbound Medicine ER -