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Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease.
Neurodegener Dis. 2016; 16(3-4):199-205.ND

Abstract

BACKGROUND AND OBJECTIVES

Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying.

METHODS

Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T1/2) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group.

RESULTS

The serum 25-hydroxyvitamin D3 levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 ± 4.90 vs. 19.43 ± 6.91 and 32.69 ± 4.93, respectively, p < 0.01). In the multivariate model, the serum 25-hydroxyvitamin D3 level was independently associated with delayed gastric emptying in PD patients.

CONCLUSIONS

Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD.

Authors+Show Affiliations

Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26735311

Citation

Kwon, Ki Young, et al. "Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in De Novo Parkinson's Disease." Neuro-degenerative Diseases, vol. 16, no. 3-4, 2016, pp. 199-205.
Kwon KY, Jo KD, Lee MK, et al. Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease. Neurodegener Dis. 2016;16(3-4):199-205.
Kwon, K. Y., Jo, K. D., Lee, M. K., Oh, M., Kim, E. N., Park, J., Kim, J. S., Youn, J., Oh, E., Kim, H. T., Oh, M. Y., & Jang, W. (2016). Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease. Neuro-degenerative Diseases, 16(3-4), 199-205. https://doi.org/10.1159/000441917
Kwon KY, et al. Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in De Novo Parkinson's Disease. Neurodegener Dis. 2016;16(3-4):199-205. PubMed PMID: 26735311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease. AU - Kwon,Ki Young, AU - Jo,Kwang Deog, AU - Lee,Moon Kyu, AU - Oh,Minyoung, AU - Kim,Eyu Nyong, AU - Park,Jinse, AU - Kim,Ji Sun, AU - Youn,Jinyoung, AU - Oh,Engseok, AU - Kim,Hee-Tae, AU - Oh,Mi Young, AU - Jang,Wooyoung, Y1 - 2016/01/07/ PY - 2015/05/19/received PY - 2015/10/22/accepted PY - 2016/1/7/entrez PY - 2016/1/7/pubmed PY - 2016/12/29/medline SP - 199 EP - 205 JF - Neuro-degenerative diseases JO - Neurodegener Dis VL - 16 IS - 3-4 N2 - BACKGROUND AND OBJECTIVES: Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying. METHODS: Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T1/2) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group. RESULTS: The serum 25-hydroxyvitamin D3 levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 ± 4.90 vs. 19.43 ± 6.91 and 32.69 ± 4.93, respectively, p < 0.01). In the multivariate model, the serum 25-hydroxyvitamin D3 level was independently associated with delayed gastric emptying in PD patients. CONCLUSIONS: Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD. SN - 1660-2862 UR - https://www.unboundmedicine.com/medline/citation/26735311/Low_Serum_Vitamin_D_Levels_May_Contribute_to_Gastric_Dysmotility_in_de_novo_Parkinson's_Disease_ L2 - https://www.karger.com?DOI=10.1159/000441917 DB - PRIME DP - Unbound Medicine ER -