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[Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes].
Wei Sheng Yan Jiu. 2015 Nov; 44(6):881-6.WS

Abstract

OBJECTIVE

To assess the possible role of insulin resistance (IR) and β cell function in the pathophysiology of newly diagnosed type 2 diabetics (T2DM).

METHODS

An oral glucose tolerance test was obtained at the health cohort baseline. Subjects with normal glucose tolerance (NGT, n = 269), impaired glucose regulation (IGR, n = 269) and newly diagnosed type 2 diabetics (T2DM, n = 269) were defined by ADA criteria. Subjects with NGT and IGR were selected from residents living in the same community of diabetic patients with the same gender and age (± 3 years old). The T2DM group was sub-classified as isolated fasting hyperglycemia (IFH), isolated post-challenge hyperglycemia (IPH) and combined hyperglycemia (CH). The IGR group was sub-classified as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI). Homeostasis model assessment of insulin resistance (HOMA-IR), β cell function (HOMA-β) and deposition index (DI) were to evaluate the insulin resistance or sensitivity, islet β cell function and that when insulin compensated respectively.

RESULTS

From NGT to T2DM, HOMA-IR increased while HOMA-β and DI decreased significantly (P < 0.05). After the adjustment of age, gender, obesity and hypertension, IFG and CGI subgroup had statistically higher HOMA-IR and lower HOMA-β and DI, and IGT subgroup only had lower HOMA-β and DI than NGT subgroup (P < 0.05). Compared to IGT subgroup, IFG and CGI subgroup had significantly higher HOMA-IR and lower HOMA-β and DI (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFH subgroup (P < 0.05), DI of CH subgroup significantly decreased than that of IPH subgroup (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFG and CGI subgroup respectively. HOMA-β and DI decreased of IPH subgroup compared to IGT subgroup, and multiple linear regression analysis showed that HOMA-IR had significant influence on fasting plasma glucose (FPG) in NGT (P < 0.05), whereas two-hour plasma glucose and FPG were influenced by DI (P < 0.05) in the progression.

CONCLUSIONS

Both basic β cell dysfunction and IR exist in IFG and CGI, while only basic β cell dysfunction exist in IGT. The basic β cell dysfunction and IR are the primary features of fasting hyperglycemia, and basic β cell dysfunction also contribute to post- challenge hyperglycemia.

Authors

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Pub Type(s)

Journal Article

Language

chi

PubMed ID

26738376

Citation

Chen, Xiaoying, et al. "[Role of Insulin Resistance and Β Cell Function in the Development of Newly Diagnosed Type 2 Diabetes]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 44, no. 6, 2015, pp. 881-6.
Chen X, Su M, Wang C, et al. [Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes]. Wei Sheng Yan Jiu. 2015;44(6):881-6.
Chen, X., Su, M., Wang, C., Wu, Z., Li, S., Ying, X., Wei, G., Fu, C., & Jiang, Q. (2015). [Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 44(6), 881-6.
Chen X, et al. [Role of Insulin Resistance and Β Cell Function in the Development of Newly Diagnosed Type 2 Diabetes]. Wei Sheng Yan Jiu. 2015;44(6):881-6. PubMed PMID: 26738376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes]. AU - Chen,Xiaoying, AU - Su,Meifang, AU - Wang,Congyun, AU - Wu,Zhaofan, AU - Li,Songtao, AU - Ying,Xuhua, AU - Wei,Guorong, AU - Fu,Chaowei, AU - Jiang,Qingwu, PY - 2016/1/8/entrez PY - 2016/1/8/pubmed PY - 2016/2/20/medline SP - 881 EP - 6 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 44 IS - 6 N2 - OBJECTIVE: To assess the possible role of insulin resistance (IR) and β cell function in the pathophysiology of newly diagnosed type 2 diabetics (T2DM). METHODS: An oral glucose tolerance test was obtained at the health cohort baseline. Subjects with normal glucose tolerance (NGT, n = 269), impaired glucose regulation (IGR, n = 269) and newly diagnosed type 2 diabetics (T2DM, n = 269) were defined by ADA criteria. Subjects with NGT and IGR were selected from residents living in the same community of diabetic patients with the same gender and age (± 3 years old). The T2DM group was sub-classified as isolated fasting hyperglycemia (IFH), isolated post-challenge hyperglycemia (IPH) and combined hyperglycemia (CH). The IGR group was sub-classified as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI). Homeostasis model assessment of insulin resistance (HOMA-IR), β cell function (HOMA-β) and deposition index (DI) were to evaluate the insulin resistance or sensitivity, islet β cell function and that when insulin compensated respectively. RESULTS: From NGT to T2DM, HOMA-IR increased while HOMA-β and DI decreased significantly (P < 0.05). After the adjustment of age, gender, obesity and hypertension, IFG and CGI subgroup had statistically higher HOMA-IR and lower HOMA-β and DI, and IGT subgroup only had lower HOMA-β and DI than NGT subgroup (P < 0.05). Compared to IGT subgroup, IFG and CGI subgroup had significantly higher HOMA-IR and lower HOMA-β and DI (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFH subgroup (P < 0.05), DI of CH subgroup significantly decreased than that of IPH subgroup (P < 0.05). IFH and CH subgroup had statistically higher HOMA-IR and lower HOMA-β and DI than IFG and CGI subgroup respectively. HOMA-β and DI decreased of IPH subgroup compared to IGT subgroup, and multiple linear regression analysis showed that HOMA-IR had significant influence on fasting plasma glucose (FPG) in NGT (P < 0.05), whereas two-hour plasma glucose and FPG were influenced by DI (P < 0.05) in the progression. CONCLUSIONS: Both basic β cell dysfunction and IR exist in IFG and CGI, while only basic β cell dysfunction exist in IGT. The basic β cell dysfunction and IR are the primary features of fasting hyperglycemia, and basic β cell dysfunction also contribute to post- challenge hyperglycemia. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/26738376/[Role_of_insulin_resistance_and_β_cell_function_in_the_development_of_newly_diagnosed_type_2_diabetes]_ L2 - http://www.diseaseinfosearch.org/result/2243 DB - PRIME DP - Unbound Medicine ER -