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Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study.
Eur J Nucl Med Mol Imaging 2016; 43(6):1067-76EJ

Abstract

PURPOSE

The objective of this study was to evaluate the amyloid burden, as assessed by (18)F-florbetapir (AV-45/Amyvid) positron emission tomography PET, in patients with major depressive disorder (MDD) with different subtypes of mild cognitive impairment (MCI) and the relationship between amyloid burden and cognition in MDD patients.

METHODS

The study included 55 MDD patients without dementia and 21 healthy control subjects (HCs) who were assessed using a comprehensive cognitive test battery and (18)F-florbetapir PET imaging. The standardized uptake value ratios (SUVR) in eight cortical regions using the whole cerebellum as reference region were determined and voxel-wise comparisons between the HC and MDD groups were performed. Vascular risk factors, serum homocysteine level and the apolipoprotein E (ApoE) genotype were also determined.

RESULTS

Among the 55 MDD patients, 22 (40.0 %) had MCI, 12 (21.8 %) non-amnestic MCI (naMCI) and 10 (18.2 %) amnestic MCI (aMCI). The MDD patients with aMCI had the highest relative (18)F-florbetapir uptake in all cortical regions, and a significant difference in relative (18)F-florbetapir uptake was found in the parietal region as compared with that in naMCI subjects (P < 0.05) and HCs (P < 0.01). Voxel-wise analyses revealed significantly increased relative (18)F-florbetapir uptake in the MDD patients with aMCI and naMCI in the frontal, parietal, temporal and occipital areas (P < 0.005). The global cortical SUVR was significantly negatively correlated with MMSE score (r = -0.342, P = 0.010) and memory function (r = -0.328, P = 0.015). The negative correlation between the global SUVR and memory in the MDD patients remained significant in multiple regression analyses that included age, educational level, ApoE genotype, and depression severity (β = -3.607, t = -2.874, P = 0.006).

CONCLUSION

We found preliminary evidence of brain beta-amyloid deposition in MDD patients with different subtypes of MCI. Our findings in MDD patients support the hypothesis that a higher amyloid burden is associated with a poorer memory performance. We also observed a high prevalence of MCI among elderly depressed patients, and depressed patients with MCI exhibited heterogeneously elevated (18)F-florbetapir retention as compared with depressed patients without MCI. The higher amyloid burden in the aMCI patients suggests that these patients may also be more likely to develop Alzheimer's disease than other patients diagnosed with major depression.

Authors+Show Affiliations

Department of Psychiatry, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan.Department of Psychiatry, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan.Department of Psychiatry, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Department of Psychiatry, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan.Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, 5. Fu-Hsing Street, Kuei Shan Hsiang, Taoyuan, Taiwan. Department of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, Tao-Yuan, Taiwan.Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, 5. Fu-Hsing Street, Kuei Shan Hsiang, Taoyuan, Taiwan. Department of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, Tao-Yuan, Taiwan.Department of Psychiatry, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan.Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, 5. Fu-Hsing Street, Kuei Shan Hsiang, Taoyuan, Taiwan. Department of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, Tao-Yuan, Taiwan.Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, 5. Fu-Hsing Street, Kuei Shan Hsiang, Taoyuan, Taiwan. lin4857@adm.cgmh.org.tw. Department of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, Tao-Yuan, Taiwan. lin4857@adm.cgmh.org.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26739329

Citation

Wu, Kuan-Yi, et al. "Beta-amyloid Deposition and Cognitive Function in Patients With Major Depressive Disorder With Different Subtypes of Mild Cognitive Impairment: (18)F-florbetapir (AV-45/Amyvid) PET Study." European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 6, 2016, pp. 1067-76.
Wu KY, Liu CY, Chen CS, et al. Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study. Eur J Nucl Med Mol Imaging. 2016;43(6):1067-76.
Wu, K. Y., Liu, C. Y., Chen, C. S., Chen, C. H., Hsiao, I. T., Hsieh, C. J., ... Lin, K. J. (2016). Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study. European Journal of Nuclear Medicine and Molecular Imaging, 43(6), pp. 1067-76. doi:10.1007/s00259-015-3291-3.
Wu KY, et al. Beta-amyloid Deposition and Cognitive Function in Patients With Major Depressive Disorder With Different Subtypes of Mild Cognitive Impairment: (18)F-florbetapir (AV-45/Amyvid) PET Study. Eur J Nucl Med Mol Imaging. 2016;43(6):1067-76. PubMed PMID: 26739329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: (18)F-florbetapir (AV-45/Amyvid) PET study. AU - Wu,Kuan-Yi, AU - Liu,Chia-Yih, AU - Chen,Cheng-Sheng, AU - Chen,Chia-Hsiang, AU - Hsiao,Ing-Tsung, AU - Hsieh,Chia-Ju, AU - Lee,Chin-Pang, AU - Yen,Tzu-Chen, AU - Lin,Kun-Ju, Y1 - 2016/01/07/ PY - 2015/09/01/received PY - 2015/12/10/accepted PY - 2016/1/8/entrez PY - 2016/1/8/pubmed PY - 2017/2/28/medline KW - 18F-Florbetapir (AV-45/Amyvid) KW - Alzheimer’s disease KW - Amyloid KW - Dementia KW - Major depressive disorder KW - Mild cognitive impairment SP - 1067 EP - 76 JF - European journal of nuclear medicine and molecular imaging JO - Eur. J. Nucl. Med. Mol. Imaging VL - 43 IS - 6 N2 - PURPOSE: The objective of this study was to evaluate the amyloid burden, as assessed by (18)F-florbetapir (AV-45/Amyvid) positron emission tomography PET, in patients with major depressive disorder (MDD) with different subtypes of mild cognitive impairment (MCI) and the relationship between amyloid burden and cognition in MDD patients. METHODS: The study included 55 MDD patients without dementia and 21 healthy control subjects (HCs) who were assessed using a comprehensive cognitive test battery and (18)F-florbetapir PET imaging. The standardized uptake value ratios (SUVR) in eight cortical regions using the whole cerebellum as reference region were determined and voxel-wise comparisons between the HC and MDD groups were performed. Vascular risk factors, serum homocysteine level and the apolipoprotein E (ApoE) genotype were also determined. RESULTS: Among the 55 MDD patients, 22 (40.0 %) had MCI, 12 (21.8 %) non-amnestic MCI (naMCI) and 10 (18.2 %) amnestic MCI (aMCI). The MDD patients with aMCI had the highest relative (18)F-florbetapir uptake in all cortical regions, and a significant difference in relative (18)F-florbetapir uptake was found in the parietal region as compared with that in naMCI subjects (P < 0.05) and HCs (P < 0.01). Voxel-wise analyses revealed significantly increased relative (18)F-florbetapir uptake in the MDD patients with aMCI and naMCI in the frontal, parietal, temporal and occipital areas (P < 0.005). The global cortical SUVR was significantly negatively correlated with MMSE score (r = -0.342, P = 0.010) and memory function (r = -0.328, P = 0.015). The negative correlation between the global SUVR and memory in the MDD patients remained significant in multiple regression analyses that included age, educational level, ApoE genotype, and depression severity (β = -3.607, t = -2.874, P = 0.006). CONCLUSION: We found preliminary evidence of brain beta-amyloid deposition in MDD patients with different subtypes of MCI. Our findings in MDD patients support the hypothesis that a higher amyloid burden is associated with a poorer memory performance. We also observed a high prevalence of MCI among elderly depressed patients, and depressed patients with MCI exhibited heterogeneously elevated (18)F-florbetapir retention as compared with depressed patients without MCI. The higher amyloid burden in the aMCI patients suggests that these patients may also be more likely to develop Alzheimer's disease than other patients diagnosed with major depression. SN - 1619-7089 UR - https://www.unboundmedicine.com/medline/citation/26739329/Beta_amyloid_deposition_and_cognitive_function_in_patients_with_major_depressive_disorder_with_different_subtypes_of_mild_cognitive_impairment:__18_F_florbetapir__AV_45/Amyvid__PET_study_ L2 - https://dx.doi.org/10.1007/s00259-015-3291-3 DB - PRIME DP - Unbound Medicine ER -