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Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats.
Hypertens Res. 2016 May; 39(5):312-20.HR

Abstract

We report that disturbance to the circadian rhythm of urinary angiotensinogen (AGT) excretion may lead to renal damage, hypertension and diurnal blood pressure (BP) variations. We aim to clarify the circadian rhythm of the intrarenal renin-angiotensin system (RAS) and its contribution to renal damage, hypertension and BP variations, and to evaluate whether the administration of RAS blockers influences the circadian rhythms of intrarenal RAS components. Anti-thymocyte serum (ATS) nephritis rats were used as a chronic progressive glomerulonephritis model (group A) and compared with control rats (group C). Other rats with ATS nephritis received olmesartan medoxomil (an angiotensin II (AngII) type 1 receptor (AT1R) blocker; group AO) or hydralazine (a vasodilator; group AH). The levels of intrarenal RAS components were evaluated every 6 h. The expression levels of intrarenal AGT, AngII and AT1R were increased in group A and peaked at the same time as BP and urinary protein excretion during the rest phase. The amplitude of the circadian fluctuation of these proteins was more increased in group A than in group C. The circadian fluctuation of these proteins was reduced in groups AO and AH. However, renal function, proteinuria and augmentation of intrarenal RAS components were reduced only in group AO. Intrarenal RAS components, such as AGT, AngII and AT1R proteins, were increased and the amplitude of the oscillations of these proteins was augmented in ATS nephritis rats. Interestingly, renal damage may be linked to the activation of the intrarenal RAS independent of the amplitude of its oscillations and BP.

Authors+Show Affiliations

Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.Blood Purification Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan.Blood Purification Unit, Hamamatsu University School of Medicine, Hamamatsu, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.Department of Pharmacology, Kagawa University, Kagawa, Japan.Internal Medicine 1, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26739872

Citation

Isobe, Shinsuke, et al. "Augmented Circadian Rhythm of the Intrarenal Renin-angiotensin Systems in Anti-thymocyte Serum Nephritis Rats." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 39, no. 5, 2016, pp. 312-20.
Isobe S, Ohashi N, Ishigaki S, et al. Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats. Hypertens Res. 2016;39(5):312-20.
Isobe, S., Ohashi, N., Ishigaki, S., Tsuji, T., Sakao, Y., Kato, A., Miyajima, H., Fujigaki, Y., Nishiyama, A., & Yasuda, H. (2016). Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 39(5), 312-20. https://doi.org/10.1038/hr.2015.151
Isobe S, et al. Augmented Circadian Rhythm of the Intrarenal Renin-angiotensin Systems in Anti-thymocyte Serum Nephritis Rats. Hypertens Res. 2016;39(5):312-20. PubMed PMID: 26739872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Augmented circadian rhythm of the intrarenal renin-angiotensin systems in anti-thymocyte serum nephritis rats. AU - Isobe,Shinsuke, AU - Ohashi,Naro, AU - Ishigaki,Sayaka, AU - Tsuji,Takayuki, AU - Sakao,Yukitoshi, AU - Kato,Akihiko, AU - Miyajima,Hiroaki, AU - Fujigaki,Yoshihide, AU - Nishiyama,Akira, AU - Yasuda,Hideo, Y1 - 2016/01/07/ PY - 2015/07/14/received PY - 2015/11/03/revised PY - 2015/12/03/accepted PY - 2016/1/8/entrez PY - 2016/1/8/pubmed PY - 2017/8/8/medline SP - 312 EP - 20 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens. Res. VL - 39 IS - 5 N2 - We report that disturbance to the circadian rhythm of urinary angiotensinogen (AGT) excretion may lead to renal damage, hypertension and diurnal blood pressure (BP) variations. We aim to clarify the circadian rhythm of the intrarenal renin-angiotensin system (RAS) and its contribution to renal damage, hypertension and BP variations, and to evaluate whether the administration of RAS blockers influences the circadian rhythms of intrarenal RAS components. Anti-thymocyte serum (ATS) nephritis rats were used as a chronic progressive glomerulonephritis model (group A) and compared with control rats (group C). Other rats with ATS nephritis received olmesartan medoxomil (an angiotensin II (AngII) type 1 receptor (AT1R) blocker; group AO) or hydralazine (a vasodilator; group AH). The levels of intrarenal RAS components were evaluated every 6 h. The expression levels of intrarenal AGT, AngII and AT1R were increased in group A and peaked at the same time as BP and urinary protein excretion during the rest phase. The amplitude of the circadian fluctuation of these proteins was more increased in group A than in group C. The circadian fluctuation of these proteins was reduced in groups AO and AH. However, renal function, proteinuria and augmentation of intrarenal RAS components were reduced only in group AO. Intrarenal RAS components, such as AGT, AngII and AT1R proteins, were increased and the amplitude of the oscillations of these proteins was augmented in ATS nephritis rats. Interestingly, renal damage may be linked to the activation of the intrarenal RAS independent of the amplitude of its oscillations and BP. SN - 1348-4214 UR - https://www.unboundmedicine.com/medline/citation/26739872/Augmented_circadian_rhythm_of_the_intrarenal_renin_angiotensin_systems_in_anti_thymocyte_serum_nephritis_rats_ L2 - http://dx.doi.org/10.1038/hr.2015.151 DB - PRIME DP - Unbound Medicine ER -