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Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator.
Med Chem. 2016; 12(4):318-27.MC

Abstract

Autism spectrum disorders (ASD) may be attributed to altered composition of polyunsaturated fatty acids. We examined the relationships between the plasma ratios of docosahexaenoic acid (DHA)/arachidonic acid (AA) and eicosapentaenoic acid (EPA)/AA, and biomarkers of AA-related signaling mediators, i.e., ceruloplasmin, transferrin and superoxide dismutase, with the behavioral symptoms of 30 individuals with ASD (mean age, 13.0 years old) and 20 age- and gender-matched normal controls (mean age, 13.6 years old). Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). The ASD group had significantly higher plasma DHA/AA and EPA/AA ratios, as well as ABC scores, compared to the control group. The plasma ceruloplasmin levels in the ASD group were significantly reduced compared to those in the control group. Multiple linear regression demonstrated that plasma DHA/AA ratio was a fitting model for distinguishing the ASD group from the control group. These findings suggested that increased plasma DHA/AA ratio may be related to lower plasma levels of ceruloplasmin, which may contribute to the pathophysiology of behavioral symptoms in 30 individuals with ASD.

Authors+Show Affiliations

Research Institute of Pervasive Developmental Disorders, Ashiya University, 13-22 Rokurokusocho, Ashiya, 659-8511, Hyogo, Japan. yui16@bell.ocn.ne.jp.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26740205

Citation

Yui, Kunio, et al. "Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid Is Related to Down-Regulation of a Signaling Mediator." Medicinal Chemistry (Shariqah (United Arab Emirates)), vol. 12, no. 4, 2016, pp. 318-27.
Yui K, Imataka G, Kawasaki Y. Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator. Med Chem. 2016;12(4):318-27.
Yui, K., Imataka, G., & Kawasaki, Y. (2016). Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator. Medicinal Chemistry (Shariqah (United Arab Emirates)), 12(4), 318-27.
Yui K, Imataka G, Kawasaki Y. Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid Is Related to Down-Regulation of a Signaling Mediator. Med Chem. 2016;12(4):318-27. PubMed PMID: 26740205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator. AU - Yui,Kunio, AU - Imataka,George, AU - Kawasaki,Yohei, PY - 2015/06/06/received PY - 2015/12/02/revised PY - 2015/12/29/accepted PY - 2016/1/8/entrez PY - 2016/1/8/pubmed PY - 2017/7/5/medline SP - 318 EP - 27 JF - Medicinal chemistry (Shariqah (United Arab Emirates)) JO - Med Chem VL - 12 IS - 4 N2 - Autism spectrum disorders (ASD) may be attributed to altered composition of polyunsaturated fatty acids. We examined the relationships between the plasma ratios of docosahexaenoic acid (DHA)/arachidonic acid (AA) and eicosapentaenoic acid (EPA)/AA, and biomarkers of AA-related signaling mediators, i.e., ceruloplasmin, transferrin and superoxide dismutase, with the behavioral symptoms of 30 individuals with ASD (mean age, 13.0 years old) and 20 age- and gender-matched normal controls (mean age, 13.6 years old). Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). The ASD group had significantly higher plasma DHA/AA and EPA/AA ratios, as well as ABC scores, compared to the control group. The plasma ceruloplasmin levels in the ASD group were significantly reduced compared to those in the control group. Multiple linear regression demonstrated that plasma DHA/AA ratio was a fitting model for distinguishing the ASD group from the control group. These findings suggested that increased plasma DHA/AA ratio may be related to lower plasma levels of ceruloplasmin, which may contribute to the pathophysiology of behavioral symptoms in 30 individuals with ASD. SN - 1875-6638 UR - https://www.unboundmedicine.com/medline/citation/26740205/Competitive_Interaction_Between_Plasma_Omega_3_Fatty_Acids_and_Arachidonic_Acid_is_Related_to_Down_Regulation_of_A_Signaling_Mediator_ L2 - http://www.eurekaselect.com/138374/article DB - PRIME DP - Unbound Medicine ER -