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Coenzyme Q-10 in Human Health: Supporting Evidence?
South Med J. 2016 Jan; 109(1):17-21.SM

Abstract

Coenzyme Q-10 (CoQ10) is a widely used alternative medication or dietary supplement and one of its roles is as an antioxidant. It naturally functions as a coenzyme and component of oxidative phosphorylation in mitochondria. Decreased levels have been demonstrated in diseased myocardium and in Parkinson disease. Farnesyl pyrophosphate is a critical intermediate for CoQ10 synthesis and blockage of this step may be important in statin myopathy. Deficiency of CoQ10 also has been associated with encephalomyopathy, severe infantile multisystemic disease, cerebellar ataxia, nephrotic syndrome, and isolated myopathy. Although supplementation with CoQ10 has been reported to be beneficial in treating hypertension, congestive heart failure, statin myopathy, and problems associated with chemotherapy for cancer treatement, this use of CoQ10 as a supplement has not been confirmed in randomized controlled clinical trials. Nevertheless, it appears to be a safe supplementary medication where usage in selected clinical situations may not be inappropriate. This review is an attempt to actualize the available information on CoQ10 and define its potential benefit and appropriate usage.

Authors+Show Affiliations

From the Division of Cardiothoracic Surgery and the Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington.From the Division of Cardiothoracic Surgery and the Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26741866

Citation

Saha, Sibu P., and Thomas F. Whayne. "Coenzyme Q-10 in Human Health: Supporting Evidence?" Southern Medical Journal, vol. 109, no. 1, 2016, pp. 17-21.
Saha SP, Whayne TF. Coenzyme Q-10 in Human Health: Supporting Evidence? South Med J. 2016;109(1):17-21.
Saha, S. P., & Whayne, T. F. (2016). Coenzyme Q-10 in Human Health: Supporting Evidence? Southern Medical Journal, 109(1), 17-21. https://doi.org/10.14423/SMJ.0000000000000393
Saha SP, Whayne TF. Coenzyme Q-10 in Human Health: Supporting Evidence. South Med J. 2016;109(1):17-21. PubMed PMID: 26741866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q-10 in Human Health: Supporting Evidence? AU - Saha,Sibu P, AU - Whayne,Thomas F,Jr PY - 2016/1/8/entrez PY - 2016/1/8/pubmed PY - 2016/5/10/medline SP - 17 EP - 21 JF - Southern medical journal JO - South. Med. J. VL - 109 IS - 1 N2 - Coenzyme Q-10 (CoQ10) is a widely used alternative medication or dietary supplement and one of its roles is as an antioxidant. It naturally functions as a coenzyme and component of oxidative phosphorylation in mitochondria. Decreased levels have been demonstrated in diseased myocardium and in Parkinson disease. Farnesyl pyrophosphate is a critical intermediate for CoQ10 synthesis and blockage of this step may be important in statin myopathy. Deficiency of CoQ10 also has been associated with encephalomyopathy, severe infantile multisystemic disease, cerebellar ataxia, nephrotic syndrome, and isolated myopathy. Although supplementation with CoQ10 has been reported to be beneficial in treating hypertension, congestive heart failure, statin myopathy, and problems associated with chemotherapy for cancer treatement, this use of CoQ10 as a supplement has not been confirmed in randomized controlled clinical trials. Nevertheless, it appears to be a safe supplementary medication where usage in selected clinical situations may not be inappropriate. This review is an attempt to actualize the available information on CoQ10 and define its potential benefit and appropriate usage. SN - 1541-8243 UR - https://www.unboundmedicine.com/medline/citation/26741866/Coenzyme_Q_10_in_Human_Health:_Supporting_Evidence L2 - http://dx.doi.org/10.14423/SMJ.0000000000000393 DB - PRIME DP - Unbound Medicine ER -