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Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak.
Jpn J Infect Dis. 2016 Sep 21; 69(5):361-6.JJ

Abstract

The Korea Middle East respiratory syndrome coronavirus (MERS-CoV) was first confirmed on May 20, 2015, with a subsequent outbreak in South Korea. Five patients with suspected MERS-CoA infection were admitted to our hospital during this outbreak. One patient had no major symptoms upon admission, but pneumonia was identified upon chest radiography. Two patients progressed rapidly to acute respiratory failure and required ventilator-assisted respiration. One patient required extracorporeal membrane oxygenation to treat refractory hypoxemia, and one patient died of shock with multiorgan failure. All the patients had fever, myalgia, leucopenia, normal procalcitonin level, and pneumonia. Importantly, clinicians should test for pneumonia in all suspected patients with MERS-CoV infection, even in the absence of respiratory symptoms. The pneumonia usually affected the lower lobes. A shorter incubation period was associated with more severe disease and greater risk of mortality, and the severity of fever predicted the prognosis of MERS-CoV infection-related pneumonia. Therefore, in cases of lower-lobe pneumonia that occur during an MERS-CoV outbreak and are unesponsive to antibiotics, clinicians should consider the possibility of MERS-CoV infection.

Authors+Show Affiliations

Division of Infectious diseases, Department of Medicine, Dankook University Hospital.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26743151

Citation

Rhee, Ji-Young, et al. "Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak." Japanese Journal of Infectious Diseases, vol. 69, no. 5, 2016, pp. 361-6.
Rhee JY, Hong G, Ryu KM. Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak. Jpn J Infect Dis. 2016;69(5):361-6.
Rhee, J. Y., Hong, G., & Ryu, K. M. (2016). Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak. Japanese Journal of Infectious Diseases, 69(5), 361-6. https://doi.org/10.7883/yoken.JJID.2015.445
Rhee JY, Hong G, Ryu KM. Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak. Jpn J Infect Dis. 2016 Sep 21;69(5):361-6. PubMed PMID: 26743151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Implications of 5 Cases of Middle East Respiratory Syndrome Coronavirus Infection in a South Korean Outbreak. AU - Rhee,Ji-Young, AU - Hong,Goohyeon, AU - Ryu,Kyoung Min, Y1 - 2016/01/08/ PY - 2016/1/9/entrez PY - 2016/1/9/pubmed PY - 2017/3/23/medline SP - 361 EP - 6 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 69 IS - 5 N2 - The Korea Middle East respiratory syndrome coronavirus (MERS-CoV) was first confirmed on May 20, 2015, with a subsequent outbreak in South Korea. Five patients with suspected MERS-CoA infection were admitted to our hospital during this outbreak. One patient had no major symptoms upon admission, but pneumonia was identified upon chest radiography. Two patients progressed rapidly to acute respiratory failure and required ventilator-assisted respiration. One patient required extracorporeal membrane oxygenation to treat refractory hypoxemia, and one patient died of shock with multiorgan failure. All the patients had fever, myalgia, leucopenia, normal procalcitonin level, and pneumonia. Importantly, clinicians should test for pneumonia in all suspected patients with MERS-CoV infection, even in the absence of respiratory symptoms. The pneumonia usually affected the lower lobes. A shorter incubation period was associated with more severe disease and greater risk of mortality, and the severity of fever predicted the prognosis of MERS-CoV infection-related pneumonia. Therefore, in cases of lower-lobe pneumonia that occur during an MERS-CoV outbreak and are unesponsive to antibiotics, clinicians should consider the possibility of MERS-CoV infection. SN - 1884-2836 UR - https://www.unboundmedicine.com/medline/citation/26743151/Clinical_Implications_of_5_Cases_of_Middle_East_Respiratory_Syndrome_Coronavirus_Infection_in_a_South_Korean_Outbreak_ L2 - https://dx.doi.org/10.7883/yoken.JJID.2015.445 DB - PRIME DP - Unbound Medicine ER -