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Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases.
Asian Pac J Cancer Prev. 2015; 16(18):8377-82.AP

Abstract

BACKGROUND

The aim of this study was to evaluate any association between a single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409, C>G) and the development and prognosis in patients with hepatocellular carcinoma (HCC).

MATERIALS AND METHODS

Two hundred heathy controls and 388 HCC cases were included: 211 with HBV, 98 patients with HCV, 29 with alcoholic steatohepatitis (ASH) and 52 with non-alcoholic steatohepatitis (NASH). The SNP was determined by real-time PCR based on TaqMan assays.

RESULTS

The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%). The GG genotype had significantly higher distribution in patients with ASH/NASH-related HCC compared with controls (OR=2.34, 95% CI=1.16-4.71, P=0.018), and viral-related HCC cases (OR=2.15, 95% CI=1.13-4.08, P=0.020). However, the frequency of the GG genotype was similar between controls and patients with viral-related HCC. At initial diagnosis, HBV-related HCC were larger and at more advanced BCLC stage than the other HCC groups. There were no significant differences between the GG and non-GG groups regarding clinical characteristics, tumor stage and overall survival.

CONCLUSIONS

These data suggest an influence of the PNPLA3 polymorphism on the occurrence of HCC in patients with ASH/NASH but not among those with chronic viral hepatitis. However, the polymorphism was not associated with the prognosis of HCC.

Authors+Show Affiliations

Department of Biochemistry Research Unit of Hepatitis and Liver Cancer, Chulalongkorn University, Bangkok, Thailand E-mail : pisittkvn@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26745088

Citation

Khlaiphuengsin, Apichaya, et al. "Association of PNPLA3 Polymorphism With Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 16, no. 18, 2015, pp. 8377-82.
Khlaiphuengsin A, Kiatbumrung R, Payungporn S, et al. Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases. Asian Pac J Cancer Prev. 2015;16(18):8377-82.
Khlaiphuengsin, A., Kiatbumrung, R., Payungporn, S., Pinjaroen, N., & Tangkijvanich, P. (2015). Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases. Asian Pacific Journal of Cancer Prevention : APJCP, 16(18), 8377-82.
Khlaiphuengsin A, et al. Association of PNPLA3 Polymorphism With Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases. Asian Pac J Cancer Prev. 2015;16(18):8377-82. PubMed PMID: 26745088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases. AU - Khlaiphuengsin,Apichaya, AU - Kiatbumrung,Rattanaporn, AU - Payungporn,Sunchai, AU - Pinjaroen,Nutcha, AU - Tangkijvanich,Pisit, PY - 2016/1/9/entrez PY - 2016/1/9/pubmed PY - 2016/10/7/medline SP - 8377 EP - 82 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 16 IS - 18 N2 - BACKGROUND: The aim of this study was to evaluate any association between a single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409, C>G) and the development and prognosis in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Two hundred heathy controls and 388 HCC cases were included: 211 with HBV, 98 patients with HCV, 29 with alcoholic steatohepatitis (ASH) and 52 with non-alcoholic steatohepatitis (NASH). The SNP was determined by real-time PCR based on TaqMan assays. RESULTS: The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%). The GG genotype had significantly higher distribution in patients with ASH/NASH-related HCC compared with controls (OR=2.34, 95% CI=1.16-4.71, P=0.018), and viral-related HCC cases (OR=2.15, 95% CI=1.13-4.08, P=0.020). However, the frequency of the GG genotype was similar between controls and patients with viral-related HCC. At initial diagnosis, HBV-related HCC were larger and at more advanced BCLC stage than the other HCC groups. There were no significant differences between the GG and non-GG groups regarding clinical characteristics, tumor stage and overall survival. CONCLUSIONS: These data suggest an influence of the PNPLA3 polymorphism on the occurrence of HCC in patients with ASH/NASH but not among those with chronic viral hepatitis. However, the polymorphism was not associated with the prognosis of HCC. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/26745088/Association_of_PNPLA3_Polymorphism_with_Hepatocellular_Carcinoma_Development_and_Prognosis_in_Viral_and_Non_Viral_Chronic_Liver_Diseases_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:26745088&key=2015.16.18.8377 DB - PRIME DP - Unbound Medicine ER -