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Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area.
Eur J Nutr. 2017 Apr; 56(3):965-971.EJ

Abstract

PURPOSE

The relationship between iodine intake and development of thyroid diseases shows a U-shaped curve with an increase of risk in both deficient and excessive iodine intakes. Our aim was to investigate the relationship between iodine intake and thyroid cancer in patients with thyroid nodules in an iodine-replete area.

METHODS

Retrospective analysis of 1170 patients with thyroid nodules was performed. Urinary iodine concentration (UIC) was measured by inductively-coupled plasma mass spectrometry. Predictive factors for thyroid cancer were evaluated using multivariate logistic regression models.

RESULTS

The median UIC in all patients with thyroid nodules was 360 μg/L (range from 4 to 9631 μg/L). More than half of the patients (650/1170, 56 %) belonged to the category of excessive iodine intake (UIC ≥ 300 μg/L) according to WHO iodine recommendations. Patients with thyroid cancer were more likely to be distributed in UIC < 300 μg/L and in UIC ≥ 2500 μg/L than those with benign thyroid nodules. Male gender (OR 1.528, p = 0.028) and UIC were independent predictors for thyroid cancer. The multivariate-adjusted OR (95 % CI) in the relatively low (UIC < 300 μg/L) and extremely excessive (UIC ≥ 2500 μg/L) iodine intake groups for thyroid cancer were 1.519 (1.099-2.098) and 1.874 (1.094-3.208), respectively, compared to the other iodine intake group (300-2499 μg/L).

CONCLUSION

Male gender and UIC were independent predictors of thyroid cancer in patients with thyroid nodules. This study suggests that relatively low and extremely excessive iodine intakes are associated with thyroid cancer in an iodine-replete area.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. thyroid@skku.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26746218

Citation

Kim, Hye Jeong, et al. "Strong Association of Relatively Low and Extremely Excessive Iodine Intakes With Thyroid Cancer in an Iodine-replete Area." European Journal of Nutrition, vol. 56, no. 3, 2017, pp. 965-971.
Kim HJ, Kim NK, Park HK, et al. Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area. Eur J Nutr. 2017;56(3):965-971.
Kim, H. J., Kim, N. K., Park, H. K., Byun, D. W., Suh, K., Yoo, M. H., Min, Y. K., Kim, S. W., & Chung, J. H. (2017). Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area. European Journal of Nutrition, 56(3), 965-971. https://doi.org/10.1007/s00394-015-1144-2
Kim HJ, et al. Strong Association of Relatively Low and Extremely Excessive Iodine Intakes With Thyroid Cancer in an Iodine-replete Area. Eur J Nutr. 2017;56(3):965-971. PubMed PMID: 26746218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strong association of relatively low and extremely excessive iodine intakes with thyroid cancer in an iodine-replete area. AU - Kim,Hye Jeong, AU - Kim,Na Kyung, AU - Park,Hyeong Kyu, AU - Byun,Dong Won, AU - Suh,Kyoil, AU - Yoo,Myung Hi, AU - Min,Yong-Ki, AU - Kim,Sun Wook, AU - Chung,Jae Hoon, Y1 - 2016/01/08/ PY - 2015/09/25/received PY - 2015/12/16/accepted PY - 2016/1/10/pubmed PY - 2017/8/26/medline PY - 2016/1/10/entrez KW - Iodine KW - Thyroid cancer KW - Thyroid nodules SP - 965 EP - 971 JF - European journal of nutrition JO - Eur J Nutr VL - 56 IS - 3 N2 - PURPOSE: The relationship between iodine intake and development of thyroid diseases shows a U-shaped curve with an increase of risk in both deficient and excessive iodine intakes. Our aim was to investigate the relationship between iodine intake and thyroid cancer in patients with thyroid nodules in an iodine-replete area. METHODS: Retrospective analysis of 1170 patients with thyroid nodules was performed. Urinary iodine concentration (UIC) was measured by inductively-coupled plasma mass spectrometry. Predictive factors for thyroid cancer were evaluated using multivariate logistic regression models. RESULTS: The median UIC in all patients with thyroid nodules was 360 μg/L (range from 4 to 9631 μg/L). More than half of the patients (650/1170, 56 %) belonged to the category of excessive iodine intake (UIC ≥ 300 μg/L) according to WHO iodine recommendations. Patients with thyroid cancer were more likely to be distributed in UIC < 300 μg/L and in UIC ≥ 2500 μg/L than those with benign thyroid nodules. Male gender (OR 1.528, p = 0.028) and UIC were independent predictors for thyroid cancer. The multivariate-adjusted OR (95 % CI) in the relatively low (UIC < 300 μg/L) and extremely excessive (UIC ≥ 2500 μg/L) iodine intake groups for thyroid cancer were 1.519 (1.099-2.098) and 1.874 (1.094-3.208), respectively, compared to the other iodine intake group (300-2499 μg/L). CONCLUSION: Male gender and UIC were independent predictors of thyroid cancer in patients with thyroid nodules. This study suggests that relatively low and extremely excessive iodine intakes are associated with thyroid cancer in an iodine-replete area. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26746218/Strong_association_of_relatively_low_and_extremely_excessive_iodine_intakes_with_thyroid_cancer_in_an_iodine_replete_area_ L2 - https://dx.doi.org/10.1007/s00394-015-1144-2 DB - PRIME DP - Unbound Medicine ER -