Tags

Type your tag names separated by a space and hit enter

Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex.
Clin Exp Pharmacol Physiol. 2016 Apr; 43(4):484-93.CE

Abstract

Cardiovascular (CV) representation has been identified within the insular cortex (IC) and a lateralization of function previously suggested. In order to further understand the role of IC on cardiovascular control, the present study compared the CV responses evoked by stimulation of N-metil-D-aspartate (NMDA) receptors in the right and left posterior IC at different rostrocaudal levels. Intracortical microinjections of NMDA were performed into the IC of male Wistar rats anaesthetized with urethane (1.4 g/kg) prepared for blood pressure, heart rate and renal sympathetic nerve activity. Gene expression of NMDA receptor subunits NR2A and NR2B in the IC was confirmed by RT-PCR. Immunofluorescence for the NMDA receptor NR1 subunit was demonstrated in the IC (coordinates anteroposterior (AP) +1.5, 0.0 and -1.5 mm). A cardiac sympathoinhibitory site was identified, more rostrally located than identified in previous studies. A site of sympathoexcitatory cardiac control was identified more caudal to this region in agreement with earlier work. Under the experimental conditions, no lateralization of cardiovascular function was identified with chemical stimulation eliciting the same responses from either left or right insular cortices. No tonic role of the insula on cardiovascular control was identified with the use of the NMDA antagonist, AP-5. Peri-insular microinjection of NMDA was without cardiovascular effect indicating the specificity of the insula as a cardiovascular regulatory site. The current study reveals a functional topography for autonomic cardiovascular control along the rostrocaudal axis of the posterior IC.

Authors+Show Affiliations

Department of Physiology and Biophysics, INCT, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.Department of Physiology and Biophysics, INCT, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.Department of Physiology and Biophysics, INCT, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.Department of Physiology, Georgia Regents University, Augusta, GA, USA.Department of Physiology and Biophysics, INCT, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.Department of Physiology, Georgia Regents University, Augusta, GA, USA.Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.Department of Physiology and Biophysics, INCT, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26748663

Citation

Marins, Fernanda Ribeiro, et al. "Functional Topography of Cardiovascular Regulation Along the Rostrocaudal Axis of the Rat Posterior Insular Cortex." Clinical and Experimental Pharmacology & Physiology, vol. 43, no. 4, 2016, pp. 484-93.
Marins FR, Limborço-Filho M, Xavier CH, et al. Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex. Clin Exp Pharmacol Physiol. 2016;43(4):484-93.
Marins, F. R., Limborço-Filho, M., Xavier, C. H., Biancardi, V. C., Vaz, G. C., Stern, J. E., Oppenheimer, S. M., & Fontes, M. A. (2016). Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex. Clinical and Experimental Pharmacology & Physiology, 43(4), 484-93. https://doi.org/10.1111/1440-1681.12542
Marins FR, et al. Functional Topography of Cardiovascular Regulation Along the Rostrocaudal Axis of the Rat Posterior Insular Cortex. Clin Exp Pharmacol Physiol. 2016;43(4):484-93. PubMed PMID: 26748663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex. AU - Marins,Fernanda Ribeiro, AU - Limborço-Filho,Marcelo, AU - Xavier,Carlos Henrique, AU - Biancardi,Vinicia C, AU - Vaz,Gisele C, AU - Stern,Javier E, AU - Oppenheimer,Stephen M, AU - Fontes,Marco Antonio Peliky, PY - 2015/06/19/received PY - 2015/12/16/revised PY - 2016/01/04/accepted PY - 2016/1/11/entrez PY - 2016/1/11/pubmed PY - 2016/12/15/medline KW - N-metil-D-aspartate (NMDA) KW - autonomic nervous system KW - cardiovascular control KW - insular cortex SP - 484 EP - 93 JF - Clinical and experimental pharmacology & physiology JO - Clin. Exp. Pharmacol. Physiol. VL - 43 IS - 4 N2 - Cardiovascular (CV) representation has been identified within the insular cortex (IC) and a lateralization of function previously suggested. In order to further understand the role of IC on cardiovascular control, the present study compared the CV responses evoked by stimulation of N-metil-D-aspartate (NMDA) receptors in the right and left posterior IC at different rostrocaudal levels. Intracortical microinjections of NMDA were performed into the IC of male Wistar rats anaesthetized with urethane (1.4 g/kg) prepared for blood pressure, heart rate and renal sympathetic nerve activity. Gene expression of NMDA receptor subunits NR2A and NR2B in the IC was confirmed by RT-PCR. Immunofluorescence for the NMDA receptor NR1 subunit was demonstrated in the IC (coordinates anteroposterior (AP) +1.5, 0.0 and -1.5 mm). A cardiac sympathoinhibitory site was identified, more rostrally located than identified in previous studies. A site of sympathoexcitatory cardiac control was identified more caudal to this region in agreement with earlier work. Under the experimental conditions, no lateralization of cardiovascular function was identified with chemical stimulation eliciting the same responses from either left or right insular cortices. No tonic role of the insula on cardiovascular control was identified with the use of the NMDA antagonist, AP-5. Peri-insular microinjection of NMDA was without cardiovascular effect indicating the specificity of the insula as a cardiovascular regulatory site. The current study reveals a functional topography for autonomic cardiovascular control along the rostrocaudal axis of the posterior IC. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/26748663/Functional_topography_of_cardiovascular_regulation_along_the_rostrocaudal_axis_of_the_rat_posterior_insular_cortex_ L2 - https://doi.org/10.1111/1440-1681.12542 DB - PRIME DP - Unbound Medicine ER -