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Are plasma mineral levels related to antibody response to influenza vaccination in older adults?
Hum Vaccin Immunother. 2016 04 02; 12(4):1003-8.HV

Abstract

INTRODUCTION

An effective immune response to vaccination may be related to nutritional status. This study examined the association of plasma mineral levels with hemagglutination inhibition (HI) titers produced in response to influenza vaccine in older adults.

METHODS

Prior to (Day 0) and 21 (range = 19-28) days after receiving the 2013-14 influenza vaccine, 109 adults ages 51-81 years, provided blood samples. Serum samples were tested for HI activity against the A/H1N1 and A/H3N2 2013-2014 vaccine virus strains. Plasma minerals were collected in zinc-free tubes and assayed by inductively coupled plasma mass spectrometry. HI titers were reported as seroprotection (≥1:40) and seroconversion (≥ 4-fold rise from Day 0 (minimum HI = 1:10) to Day 21). Both HI titers and mineral values were skewed and thus log2 transformed. Magnesium (Mg), phosphorus (P), zinc (Zn), copper (Cu), iron (Fe), potassium (K) and the Cu to Zn ratio were tested. Logistic regression analyses were used to determine the associations between mineral levels and seroconversion and seroprotection of HI titers for each influenza A strain.

RESULTS

Participants were 61% white, 28% male, 39% diabetic, and 81% overweight/obese with a mean age of 62.6 y. In logistic regression, Day 21 A/H1N1 seroprotection was associated with P and Zn at Day 21(P < 0.05). Seroconversion of A/H1N1 was associated with Day 21 Cu, P, and Mg (P < 0.03). Day 21 A/H3N2 seroprotection and seroconversion were associated with Day 21 P (P < 0.05).

CONCLUSIONS

Phosphorus was associated with seroprotection and seroconversion to influenza A after vaccination; these associations warrant additional studies with larger, more diverse population groups.

Authors+Show Affiliations

a Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA. b Department of Environmental and Occupational Health , University of Pittsburgh Graduate School of Public Health , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.d Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.d Department of Critical Care Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.e Department of Geology and Environmental Science , University of Pittsburgh , Pittsburgh , PA , USA.f Vaccine and Gene Therapy Institute of Florida , Port St. Lucie , FL , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.c Department of Family Medicine , University of Pittsburgh School of Medicine , Pittsburgh , PA , USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26751915

Citation

Kaynar, Ata Murat, et al. "Are Plasma Mineral Levels Related to Antibody Response to Influenza Vaccination in Older Adults?" Human Vaccines & Immunotherapeutics, vol. 12, no. 4, 2016, pp. 1003-8.
Kaynar AM, Nowalk MP, Lin CJ, et al. Are plasma mineral levels related to antibody response to influenza vaccination in older adults? Hum Vaccin Immunother. 2016;12(4):1003-8.
Kaynar, A. M., Nowalk, M. P., Lin, C. J., Moehling, K. K., Susick, M., Bakalov, V., Pitt, B. R., Bain, D. J., Ross, T. M., Saul, S. G., Raymund, M., & Zimmerman, R. K. (2016). Are plasma mineral levels related to antibody response to influenza vaccination in older adults? Human Vaccines & Immunotherapeutics, 12(4), 1003-8. https://doi.org/10.1080/21645515.2015.1113358
Kaynar AM, et al. Are Plasma Mineral Levels Related to Antibody Response to Influenza Vaccination in Older Adults. Hum Vaccin Immunother. 2016 04 2;12(4):1003-8. PubMed PMID: 26751915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are plasma mineral levels related to antibody response to influenza vaccination in older adults? AU - Kaynar,Ata Murat, AU - Nowalk,Mary Patricia, AU - Lin,Chyongchiou Jeng, AU - Moehling,Krissy K, AU - Susick,Michael, AU - Bakalov,Veli, AU - Pitt,Bruce R, AU - Bain,Daniel J, AU - Ross,Ted M, AU - Saul,Sean G, AU - Raymund,Mahlon, AU - Zimmerman,Richard K, Y1 - 2016/01/11/ PY - 2016/1/12/entrez PY - 2016/1/12/pubmed PY - 2017/10/27/medline KW - immunogenicity KW - influenza vaccine KW - plasma minerals SP - 1003 EP - 8 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 12 IS - 4 N2 - INTRODUCTION: An effective immune response to vaccination may be related to nutritional status. This study examined the association of plasma mineral levels with hemagglutination inhibition (HI) titers produced in response to influenza vaccine in older adults. METHODS: Prior to (Day 0) and 21 (range = 19-28) days after receiving the 2013-14 influenza vaccine, 109 adults ages 51-81 years, provided blood samples. Serum samples were tested for HI activity against the A/H1N1 and A/H3N2 2013-2014 vaccine virus strains. Plasma minerals were collected in zinc-free tubes and assayed by inductively coupled plasma mass spectrometry. HI titers were reported as seroprotection (≥1:40) and seroconversion (≥ 4-fold rise from Day 0 (minimum HI = 1:10) to Day 21). Both HI titers and mineral values were skewed and thus log2 transformed. Magnesium (Mg), phosphorus (P), zinc (Zn), copper (Cu), iron (Fe), potassium (K) and the Cu to Zn ratio were tested. Logistic regression analyses were used to determine the associations between mineral levels and seroconversion and seroprotection of HI titers for each influenza A strain. RESULTS: Participants were 61% white, 28% male, 39% diabetic, and 81% overweight/obese with a mean age of 62.6 y. In logistic regression, Day 21 A/H1N1 seroprotection was associated with P and Zn at Day 21(P < 0.05). Seroconversion of A/H1N1 was associated with Day 21 Cu, P, and Mg (P < 0.03). Day 21 A/H3N2 seroprotection and seroconversion were associated with Day 21 P (P < 0.05). CONCLUSIONS: Phosphorus was associated with seroprotection and seroconversion to influenza A after vaccination; these associations warrant additional studies with larger, more diverse population groups. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/26751915/Are_plasma_mineral_levels_related_to_antibody_response_to_influenza_vaccination_in_older_adults L2 - https://www.tandfonline.com/doi/full/10.1080/21645515.2015.1113358 DB - PRIME DP - Unbound Medicine ER -