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Optic nerve sonography: A noninvasive means of detecting raised intracranial pressure in a resource-limited setting.
J Neurosci Rural Pract. 2015 Oct-Dec; 6(4):563-7.JN

Abstract

OBJECTIVE

The aim was to assess the use of optic nerve sonography (ONS) as a quick, noninvasive diagnostic test tool for detecting raised the intracranial pressure (ICP).

MATERIALS AND METHODS

A prospective blinded observational study was conducted at Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. The study population consisted of 160 adult patients referred to the radiology department for cranial computed tomography (CT) scan. There were 80 subjects and 80 controls. Optic nerve sheath diameter (ONSD) was measured by a radiologist using a 7.5 Megahertz ultrasound probe while cranial CT was reviewed by other radiologists blinded to the ONSD.

RESULTS

Sixty-nine subjects (86.3%) had intracranial space occupying lesions (SOL) with cranial CT confirmed features of increased ICP, mean binocular ONSD of 5.7 ± 0.59 mm while 11 (13.7%) had intracranial SOL without any cranial CT evidence of increased ICP, mean binocular ONSD of 4.8 ± 0.39 mm. The difference of mean ONSD of the two groups was statistically significant (P = 0.0001). The controls had a mean binocular ONSD of 4.5 ± 0.22 mm and the difference in mean binocular ONSD for subjects with raised ICP and the controls were also statistically significant (P = 0.0001). A cut-off value of 5.2 mm (sensitivity 81.2% [95% confidence interval (CI): 69.9-89.6], specificity 100% [95% CI: 71.5-100]) was obtained from the receiver operator characteristics curve as the mean binocular ONSD that best predicts raised ICP confirmed by at least a sign on cranial CT.

CONCLUSIONS

Optic nerve sonography can differentiate between normal and elevated ICP and may serve as a useful screening tool in resource-limited practice.

Authors+Show Affiliations

Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26752428

Citation

Aduayi, Olufunso Simisola, et al. "Optic Nerve Sonography: a Noninvasive Means of Detecting Raised Intracranial Pressure in a Resource-limited Setting." Journal of Neurosciences in Rural Practice, vol. 6, no. 4, 2015, pp. 563-7.
Aduayi OS, Asaleye CM, Adetiloye VA, et al. Optic nerve sonography: A noninvasive means of detecting raised intracranial pressure in a resource-limited setting. J Neurosci Rural Pract. 2015;6(4):563-7.
Aduayi, O. S., Asaleye, C. M., Adetiloye, V. A., Komolafe, E. O., & Aduayi, V. A. (2015). Optic nerve sonography: A noninvasive means of detecting raised intracranial pressure in a resource-limited setting. Journal of Neurosciences in Rural Practice, 6(4), 563-7. https://doi.org/10.4103/0976-3147.165347
Aduayi OS, et al. Optic Nerve Sonography: a Noninvasive Means of Detecting Raised Intracranial Pressure in a Resource-limited Setting. J Neurosci Rural Pract. 2015 Oct-Dec;6(4):563-7. PubMed PMID: 26752428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optic nerve sonography: A noninvasive means of detecting raised intracranial pressure in a resource-limited setting. AU - Aduayi,Olufunso Simisola, AU - Asaleye,Christianah Mopelola, AU - Adetiloye,Victor Adebayo, AU - Komolafe,Edward Oluwole, AU - Aduayi,Victor Adovi, PY - 2016/1/12/entrez PY - 2016/1/12/pubmed PY - 2016/1/12/medline KW - Optic nerve sheath diameter KW - raised intracranial pressure KW - resource-limited settings KW - ultrasound SP - 563 EP - 7 JF - Journal of neurosciences in rural practice JO - J Neurosci Rural Pract VL - 6 IS - 4 N2 - OBJECTIVE: The aim was to assess the use of optic nerve sonography (ONS) as a quick, noninvasive diagnostic test tool for detecting raised the intracranial pressure (ICP). MATERIALS AND METHODS: A prospective blinded observational study was conducted at Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria. The study population consisted of 160 adult patients referred to the radiology department for cranial computed tomography (CT) scan. There were 80 subjects and 80 controls. Optic nerve sheath diameter (ONSD) was measured by a radiologist using a 7.5 Megahertz ultrasound probe while cranial CT was reviewed by other radiologists blinded to the ONSD. RESULTS: Sixty-nine subjects (86.3%) had intracranial space occupying lesions (SOL) with cranial CT confirmed features of increased ICP, mean binocular ONSD of 5.7 ± 0.59 mm while 11 (13.7%) had intracranial SOL without any cranial CT evidence of increased ICP, mean binocular ONSD of 4.8 ± 0.39 mm. The difference of mean ONSD of the two groups was statistically significant (P = 0.0001). The controls had a mean binocular ONSD of 4.5 ± 0.22 mm and the difference in mean binocular ONSD for subjects with raised ICP and the controls were also statistically significant (P = 0.0001). A cut-off value of 5.2 mm (sensitivity 81.2% [95% confidence interval (CI): 69.9-89.6], specificity 100% [95% CI: 71.5-100]) was obtained from the receiver operator characteristics curve as the mean binocular ONSD that best predicts raised ICP confirmed by at least a sign on cranial CT. CONCLUSIONS: Optic nerve sonography can differentiate between normal and elevated ICP and may serve as a useful screening tool in resource-limited practice. SN - 0976-3147 UR - https://www.unboundmedicine.com/medline/citation/26752428/Optic_nerve_sonography:_A_noninvasive_means_of_detecting_raised_intracranial_pressure_in_a_resource_limited_setting_ L2 - http://www.thieme-connect.com/DOI/DOI?10.4103/0976-3147.165347 DB - PRIME DP - Unbound Medicine ER -
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