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Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials.

Abstract

BACKGROUND

Migraine attack has been associated with magnesium deficiency. Previous studies investigating the effect of intravenous and oral magnesium on acute migraine attacks and the prevention of migraine have produced equivocal findings.

OBJECTIVE

To evaluate the effects of intravenous magnesium on acute migraine attacks and oral magnesium supplements on migraine prophylaxis.

STUDY DESIGN

A meta-analysis of randomized controlled trials (RCTs). Electronic databases, namely EMBASE, PubMed, the Wanfang Data Chinese Database, and the China Knowledge Resource Integrated Database were searched from inception to February 24, 2015.

METHODS

This review was conducted according to the guidelines of the PRISMA. Only RCTs evaluating the effects of intravenous or oral magnesium on migraine compared with a control group were included.

RESULTS

A total of 21 studies were included. Of which, 11 studies investigated the effects of intravenous magnesium on acute migraine (948 participants) and 10 examined the effects of oral magnesium on migraine prophylaxis (789 participants). Intravenous magnesium significantly relieved acute migraine within 15 - 45 minutes, 120 minutes, and 24 hours after the initial infusion (Odd ratios [ORs] = 0.23, 0.20, and 0.25, respectively). Oral magnesium significantly alleviated the frequency and intensity of migraine (ORs = 0.20 and 0.27).

LIMITATIONS

Some of the included studies did not adopt adequate randomization methods.

CONCLUSIONS

Intravenous magnesium reduces acute migraine attacks within 15 - 45 minutes, 120 minutes, and 24 hours after the initial infusion and oral magnesium alleviates the frequency and intensity of migraine. Intravenous and oral magnesium should be adapted as parts of multimodal approach to reduce migraine.

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  • Authors+Show Affiliations

    ,

    School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

    ,

    Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

    ,

    Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

    Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

    Source

    Pain physician 19:1 2016 Jan pg E97-112

    MeSH

    Administration, Intravenous
    Administration, Oral
    Humans
    Magnesium
    Migraine Disorders
    Randomized Controlled Trials as Topic
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26752497

    Citation

    Chiu, Hsiao-Yean, et al. "Effects of Intravenous and Oral Magnesium On Reducing Migraine: a Meta-analysis of Randomized Controlled Trials." Pain Physician, vol. 19, no. 1, 2016, pp. E97-112.
    Chiu HY, Yeh TH, Huang YC, et al. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician. 2016;19(1):E97-112.
    Chiu, H. Y., Yeh, T. H., Huang, Y. C., & Chen, P. Y. (2016). Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician, 19(1), pp. E97-112.
    Chiu HY, et al. Effects of Intravenous and Oral Magnesium On Reducing Migraine: a Meta-analysis of Randomized Controlled Trials. Pain Physician. 2016;19(1):E97-112. PubMed PMID: 26752497.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. AU - Chiu,Hsiao-Yean, AU - Yeh,Tu-Hsueh, AU - Huang,Yin-Cheng, AU - Chen,Pin-Yuan, PY - 2016/1/12/entrez PY - 2016/1/12/pubmed PY - 2016/8/31/medline SP - E97 EP - 112 JF - Pain physician JO - Pain Physician VL - 19 IS - 1 N2 - BACKGROUND: Migraine attack has been associated with magnesium deficiency. Previous studies investigating the effect of intravenous and oral magnesium on acute migraine attacks and the prevention of migraine have produced equivocal findings. OBJECTIVE: To evaluate the effects of intravenous magnesium on acute migraine attacks and oral magnesium supplements on migraine prophylaxis. STUDY DESIGN: A meta-analysis of randomized controlled trials (RCTs). Electronic databases, namely EMBASE, PubMed, the Wanfang Data Chinese Database, and the China Knowledge Resource Integrated Database were searched from inception to February 24, 2015. METHODS: This review was conducted according to the guidelines of the PRISMA. Only RCTs evaluating the effects of intravenous or oral magnesium on migraine compared with a control group were included. RESULTS: A total of 21 studies were included. Of which, 11 studies investigated the effects of intravenous magnesium on acute migraine (948 participants) and 10 examined the effects of oral magnesium on migraine prophylaxis (789 participants). Intravenous magnesium significantly relieved acute migraine within 15 - 45 minutes, 120 minutes, and 24 hours after the initial infusion (Odd ratios [ORs] = 0.23, 0.20, and 0.25, respectively). Oral magnesium significantly alleviated the frequency and intensity of migraine (ORs = 0.20 and 0.27). LIMITATIONS: Some of the included studies did not adopt adequate randomization methods. CONCLUSIONS: Intravenous magnesium reduces acute migraine attacks within 15 - 45 minutes, 120 minutes, and 24 hours after the initial infusion and oral magnesium alleviates the frequency and intensity of migraine. Intravenous and oral magnesium should be adapted as parts of multimodal approach to reduce migraine. SN - 2150-1149 UR - https://www.unboundmedicine.com/medline/citation/26752497/full_citation L2 - http://www.painphysicianjournal.com/linkout?issn=1533-3159&vol=19&page=E97 DB - PRIME DP - Unbound Medicine ER -