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Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996-2013.
Int J Cancer. 2016 Jun 01; 138(11):2616-21.IJ

Abstract

Both alcohol abuse and liver cirrhosis are known risk factors for various cancers. This article was aimed to assess the long-term risk of malignancies among patients with severe alcoholic liver disease (ALD), i.e., alcoholic liver cirrhosis and alcoholic hepatitis. A cohort of 8,796 male and 3,077 female ALD patients from 1996 to 2012 was identified from the Finnish National Hospital Discharge Register. This nationwide cohort was combined with the data from the Finnish Cancer Registry for incidence of malignancies during the years 1996-2013. The cancer cases diagnosed were compared with the number of cancers in the general population. The number of malignancies in our cohort was 1,052 vs. 368 expected. There was statistically significant excess of cancers of the liver, (standardized incidence ratio [SIR] 59.20; 95% CI 53.11-65.61), pancreas (SIR 3.71; 95% CI 2.72-4.94), pharynx (SIR 9.25; 95% CI 6.05-13.56), mouth (SIR 8.31; 95% CI 4.84-13,29), oesophagus (SIR 7.92; 95% CI 5.49-11.07), tongue (SIR 7,21; 95% CI 3.60-12.89), larynx (SIR 5.20; 95% CI 2.77-8.89), lung (SIR 2.77; 95% CI 2.27-3.32), stomach (SIR 2.76; 95% CI 1.79-4.07), kidney (SIR 2.69; 95% CI 1.84-3.79) and colon (SIR 2.33; 95% CI 1.70-3.11). There was no decreased risk of any cancer among ALD patients. Severe ALD is associated with markedly increased risk of malignancies. The risk is especially high for hepatocellular carcinoma, but also significantly increased for cancers of the upper aerodigestive tract, pancreas and kidneys, and warrants cancer surveillance in selected cases.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sahlman P
Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nissinen M
Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pukkala E
School of Health Sciences, University of Tampere, Tampere, Finland.
Färkkilä M
Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

MeSH

AdultAgedCarcinoma, HepatocellularFemaleFinlandHumansLiver Diseases, AlcoholicLiver NeoplasmsMaleMiddle AgedRegistriesRetrospective StudiesRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26756434

Citation

Sahlman, Perttu, et al. "Cancer Incidence Among Alcoholic Liver Disease Patients in Finland: a Retrospective Registry Study During Years 1996-2013." International Journal of Cancer, vol. 138, no. 11, 2016, pp. 2616-21.
Sahlman P, Nissinen M, Pukkala E, et al. Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996-2013. Int J Cancer. 2016;138(11):2616-21.
Sahlman, P., Nissinen, M., Pukkala, E., & Färkkilä, M. (2016). Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996-2013. International Journal of Cancer, 138(11), 2616-21. https://doi.org/10.1002/ijc.29995
Sahlman P, et al. Cancer Incidence Among Alcoholic Liver Disease Patients in Finland: a Retrospective Registry Study During Years 1996-2013. Int J Cancer. 2016 Jun 1;138(11):2616-21. PubMed PMID: 26756434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer incidence among alcoholic liver disease patients in Finland: A retrospective registry study during years 1996-2013. AU - Sahlman,Perttu, AU - Nissinen,Markku, AU - Pukkala,Eero, AU - Färkkilä,Martti, Y1 - 2016/01/30/ PY - 2015/10/29/received PY - 2015/12/14/revised PY - 2015/12/22/accepted PY - 2016/1/13/entrez PY - 2016/1/13/pubmed PY - 2016/8/4/medline KW - alcoholic hepatitis KW - alcoholic liver disease KW - cancer KW - hepatocellular carcinoma KW - liver cirrhosis SP - 2616 EP - 21 JF - International journal of cancer JO - Int J Cancer VL - 138 IS - 11 N2 - Both alcohol abuse and liver cirrhosis are known risk factors for various cancers. This article was aimed to assess the long-term risk of malignancies among patients with severe alcoholic liver disease (ALD), i.e., alcoholic liver cirrhosis and alcoholic hepatitis. A cohort of 8,796 male and 3,077 female ALD patients from 1996 to 2012 was identified from the Finnish National Hospital Discharge Register. This nationwide cohort was combined with the data from the Finnish Cancer Registry for incidence of malignancies during the years 1996-2013. The cancer cases diagnosed were compared with the number of cancers in the general population. The number of malignancies in our cohort was 1,052 vs. 368 expected. There was statistically significant excess of cancers of the liver, (standardized incidence ratio [SIR] 59.20; 95% CI 53.11-65.61), pancreas (SIR 3.71; 95% CI 2.72-4.94), pharynx (SIR 9.25; 95% CI 6.05-13.56), mouth (SIR 8.31; 95% CI 4.84-13,29), oesophagus (SIR 7.92; 95% CI 5.49-11.07), tongue (SIR 7,21; 95% CI 3.60-12.89), larynx (SIR 5.20; 95% CI 2.77-8.89), lung (SIR 2.77; 95% CI 2.27-3.32), stomach (SIR 2.76; 95% CI 1.79-4.07), kidney (SIR 2.69; 95% CI 1.84-3.79) and colon (SIR 2.33; 95% CI 1.70-3.11). There was no decreased risk of any cancer among ALD patients. Severe ALD is associated with markedly increased risk of malignancies. The risk is especially high for hepatocellular carcinoma, but also significantly increased for cancers of the upper aerodigestive tract, pancreas and kidneys, and warrants cancer surveillance in selected cases. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26756434/Cancer_incidence_among_alcoholic_liver_disease_patients_in_Finland:_A_retrospective_registry_study_during_years_1996_2013_ DB - PRIME DP - Unbound Medicine ER -