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Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.
J Parkinsons Dis. 2016; 6(1):153-63.JP

Abstract

BACKGROUND

Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy. Previously, we reported, from both autopsy and needle biopsy, a high prevalence of submandibular gland synucleinopathy in Parkinson's disease (PD). Here, we report on an extension of these studies to subjects with dementia with Lewy bodies (DLB) and other Lewy body disorders in 228 autopsied subjects from the Arizona Study of Aging and Neurodegenerative Disorders.

OBJECTIVE

To provide an estimate of the prevalence of histological synucleinopathy in the submandibular glands of subjects with PD and other Lewy body disorders.

METHODS

Submandibular gland sections from autopsied subjects were stained with an immunohistochemical method for α-synuclein phosphorylated at serine 129. Included were 146 cases with CNS Lewy-type synucleinopathy (LTS), composed of 46 PD, 28 DLB, 14 incidental Lewy body disease (ILBD), 33 Alzheimer's disease with Lewy bodies (ADLB) and 2 with progressive supranuclear palsy and Lewy bodies (PSPLB). Control subjects included 79 normal elderly, 15 AD, 12 PSP, 2 conticobasal degeneration (CBD) and 2 multiple system atrophy (MSA).

RESULTS

Submandibular gland LTS was found in 42/47 (89%) of the PD subjects, 20/28 (71%) DLB, 4/33 (12%) ADLB and 1/9 (11%) ILBD subjects but none of the 110 control subjects.

CONCLUSIONS

These results provide support for further clinical trials of in vivo submandibular gland diagnostic biopsy for PD and DLB. An accurate peripheral biopsy diagnosis would assist subject selection for clinical trials and could also be used to verify other biomarkers.

Links

Publisher Full Text
ncbi.nlm.nih.gov
content.iospress.com
PMC Free PDF

Authors+Show Affiliations

Beach TG
Banner Sun Health Research Institute, Sun City, AZ, USA.
Adler CH
Mayo Clinic, Scottsdale, AZ, USA.
Serrano G
Banner Sun Health Research Institute, Sun City, AZ, USA.
Sue LI
Banner Sun Health Research Institute, Sun City, AZ, USA.
Walker DG
Banner Sun Health Research Institute, Sun City, AZ, USA.
Dugger BN
University of California at San Francisco, USA.
Shill HA
Barrow Neurological Institute, Phoenix, AZ, USA.
Driver-Dunckley E
Mayo Clinic, Scottsdale, AZ, USA.
Caviness JN
Mayo Clinic, Scottsdale, AZ, USA.
Intorcia A
Banner Sun Health Research Institute, Sun City, AZ, USA.
Filon J
Banner Sun Health Research Institute, Sun City, AZ, USA.
Scott S
Banner Sun Health Research Institute, Sun City, AZ, USA.
Garcia A
Banner Sun Health Research Institute, Sun City, AZ, USA.
Hoffman B
Banner Sun Health Research Institute, Sun City, AZ, USA.
Belden CM
Banner Sun Health Research Institute, Sun City, AZ, USA.
Davis KJ
Banner Sun Health Research Institute, Sun City, AZ, USA.
Sabbagh MN
Barrow Neurological Institute, Phoenix, AZ, USA.
Arizona Parkinson's Disease Consortium
No affiliation info available

MeSH

AgedAged, 80 and overAutopsyEarly DiagnosisFemaleHumansImmunohistochemistryLewy Body DiseaseMaleParkinson DiseasePrevalenceSubmandibular Gland Diseasesalpha-Synuclein

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26756744

Citation

Beach, Thomas G., et al. "Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia With Lewy Bodies and Other Lewy Body Disorders." Journal of Parkinson's Disease, vol. 6, no. 1, 2016, pp. 153-63.
Beach TG, Adler CH, Serrano G, et al. Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders. J Parkinsons Dis. 2016;6(1):153-63.
Beach, T. G., Adler, C. H., Serrano, G., Sue, L. I., Walker, D. G., Dugger, B. N., Shill, H. A., Driver-Dunckley, E., Caviness, J. N., Intorcia, A., Filon, J., Scott, S., Garcia, A., Hoffman, B., Belden, C. M., Davis, K. J., & Sabbagh, M. N. (2016). Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders. Journal of Parkinson's Disease, 6(1), 153-63. https://doi.org/10.3233/JPD-150680
Beach TG, et al. Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia With Lewy Bodies and Other Lewy Body Disorders. J Parkinsons Dis. 2016;6(1):153-63. PubMed PMID: 26756744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders. AU - Beach,Thomas G, AU - Adler,Charles H, AU - Serrano,Geidy, AU - Sue,Lucia I, AU - Walker,D G, AU - Dugger,Brittany N, AU - Shill,Holly A, AU - Driver-Dunckley,Erika, AU - Caviness,John N, AU - Intorcia,Anthony, AU - Filon,Jessica, AU - Scott,Sarah, AU - Garcia,Angelica, AU - Hoffman,Brittany, AU - Belden,Christine M, AU - Davis,Kathryn J, AU - Sabbagh,Marwan N, AU - ,, PY - 2016/1/13/entrez PY - 2016/1/13/pubmed PY - 2017/1/18/medline KW - Biopsy KW - biomarker KW - clinical trial KW - diagnosis KW - pathology KW - therapy SP - 153 EP - 63 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 6 IS - 1 N2 - BACKGROUND: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy. Previously, we reported, from both autopsy and needle biopsy, a high prevalence of submandibular gland synucleinopathy in Parkinson's disease (PD). Here, we report on an extension of these studies to subjects with dementia with Lewy bodies (DLB) and other Lewy body disorders in 228 autopsied subjects from the Arizona Study of Aging and Neurodegenerative Disorders. OBJECTIVE: To provide an estimate of the prevalence of histological synucleinopathy in the submandibular glands of subjects with PD and other Lewy body disorders. METHODS: Submandibular gland sections from autopsied subjects were stained with an immunohistochemical method for α-synuclein phosphorylated at serine 129. Included were 146 cases with CNS Lewy-type synucleinopathy (LTS), composed of 46 PD, 28 DLB, 14 incidental Lewy body disease (ILBD), 33 Alzheimer's disease with Lewy bodies (ADLB) and 2 with progressive supranuclear palsy and Lewy bodies (PSPLB). Control subjects included 79 normal elderly, 15 AD, 12 PSP, 2 conticobasal degeneration (CBD) and 2 multiple system atrophy (MSA). RESULTS: Submandibular gland LTS was found in 42/47 (89%) of the PD subjects, 20/28 (71%) DLB, 4/33 (12%) ADLB and 1/9 (11%) ILBD subjects but none of the 110 control subjects. CONCLUSIONS: These results provide support for further clinical trials of in vivo submandibular gland diagnostic biopsy for PD and DLB. An accurate peripheral biopsy diagnosis would assist subject selection for clinical trials and could also be used to verify other biomarkers. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/26756744/Prevalence_of_Submandibular_Gland_Synucleinopathy_in_Parkinson's_Disease_Dementia_with_Lewy_Bodies_and_other_Lewy_Body_Disorders_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-150680 DB - PRIME DP - Unbound Medicine ER -