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Impact of patatin-like phospholipase domain-containing 3 gene polymorphism (rs738409) on severity of liver disease in HIV/hepatitis C virus-coinfected patients.
AIDS. 2016 Jan 28; 30(3):465-70.AIDS

Abstract

OBJECTIVE

To analyze the association between patatin-like phospholipase domain-containing 3 gene (PNPLA3) rs738409 polymorphism and severity of liver disease in HIV/hepatitis C virus-coinfected patients.

METHODS

We performed a cross-sectional study of 215 patients who underwent a liver biopsy. PNPLA3 rs738409 polymorphism was genotyped using GoldenGate assay. The outcome variables were as follows: advanced fibrosis (F ≥3 and FIB-4 ≥3.25), rapid fibrosis progression (FPR ≥0.10 fibrosis units/year), severe activity grade (A≥3), and steatosis (fatty hepatocytes ≥10%). The genetic association analysis was carried out according to an additive genetic model through logistic regressions adjusted by the most significant covariables.

RESULTS

Overall, 21.4% had F at least 3, 8.9% had FIB-4 at least 3.25, 11.4% had A at least 3, 60.6% had steatosis, and 32.5% had FPR at least 0.10. For each rs738409 G allele, we found an increased frequency of patients with advanced fibrosis (F at least 3) (0% CC, 18.5% CG, and 25.2% GG; P = 0.049) and FIB-4 at least 3.25 (0% CC, 3.8% CG, and 13.2% GG; P = 0.016). Furthermore, for each rs738409 G allele, the odds of having F at least 3 increased 2.15 times (95% confidence interval=1.07; 4.35; P = 0.029) and having FIB-4 at least 3.25 increased 8.77 times (95% of confidence interval = 1.11; 69.0; P = 0.039). Note that rs738409 G allele carriers tended to higher likelihood of having FPR at least 0.10, but statistical significance was not reached (P = 0.054). Finally, we did not find any association for A at least 3 and liver steatosis.

CONCLUSION

PNPLA3 rs738409 polymorphism was associated with the severity of liver fibrosis in patients coinfected with HIV and hepatitis C virus, suggesting that this polymorphism might also play a significant role in the progression of hepatic fibrosis in this group of patients.

Authors+Show Affiliations

aUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda bUnidad de Enfermedades Infecciosas/VIH; Hospital General Universitario "Gregorio Marañón" cInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26760234

Citation

Jiménez-Sousa, María A., et al. "Impact of Patatin-like Phospholipase Domain-containing 3 Gene Polymorphism (rs738409) On Severity of Liver Disease in HIV/hepatitis C Virus-coinfected Patients." AIDS (London, England), vol. 30, no. 3, 2016, pp. 465-70.
Jiménez-Sousa MA, Berenguer J, García-Álvarez M, et al. Impact of patatin-like phospholipase domain-containing 3 gene polymorphism (rs738409) on severity of liver disease in HIV/hepatitis C virus-coinfected patients. AIDS. 2016;30(3):465-70.
Jiménez-Sousa, M. A., Berenguer, J., García-Álvarez, M., Gutierrez-Rivas, M., Aldámiz-Echevarria, T., Tejerina, F., Diez, C., Vázquez-Morón, S., & Resino, S. (2016). Impact of patatin-like phospholipase domain-containing 3 gene polymorphism (rs738409) on severity of liver disease in HIV/hepatitis C virus-coinfected patients. AIDS (London, England), 30(3), 465-70. https://doi.org/10.1097/QAD.0000000000000908
Jiménez-Sousa MA, et al. Impact of Patatin-like Phospholipase Domain-containing 3 Gene Polymorphism (rs738409) On Severity of Liver Disease in HIV/hepatitis C Virus-coinfected Patients. AIDS. 2016 Jan 28;30(3):465-70. PubMed PMID: 26760234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of patatin-like phospholipase domain-containing 3 gene polymorphism (rs738409) on severity of liver disease in HIV/hepatitis C virus-coinfected patients. AU - Jiménez-Sousa,María A, AU - Berenguer,Juan, AU - García-Álvarez,Mónica, AU - Gutierrez-Rivas,Mónica, AU - Aldámiz-Echevarria,Teresa, AU - Tejerina,Francisco, AU - Diez,Cristina, AU - Vázquez-Morón,Sonia, AU - Resino,Salvador, PY - 2016/1/14/entrez PY - 2016/1/14/pubmed PY - 2016/10/13/medline SP - 465 EP - 70 JF - AIDS (London, England) JO - AIDS VL - 30 IS - 3 N2 - OBJECTIVE: To analyze the association between patatin-like phospholipase domain-containing 3 gene (PNPLA3) rs738409 polymorphism and severity of liver disease in HIV/hepatitis C virus-coinfected patients. METHODS: We performed a cross-sectional study of 215 patients who underwent a liver biopsy. PNPLA3 rs738409 polymorphism was genotyped using GoldenGate assay. The outcome variables were as follows: advanced fibrosis (F ≥3 and FIB-4 ≥3.25), rapid fibrosis progression (FPR ≥0.10 fibrosis units/year), severe activity grade (A≥3), and steatosis (fatty hepatocytes ≥10%). The genetic association analysis was carried out according to an additive genetic model through logistic regressions adjusted by the most significant covariables. RESULTS: Overall, 21.4% had F at least 3, 8.9% had FIB-4 at least 3.25, 11.4% had A at least 3, 60.6% had steatosis, and 32.5% had FPR at least 0.10. For each rs738409 G allele, we found an increased frequency of patients with advanced fibrosis (F at least 3) (0% CC, 18.5% CG, and 25.2% GG; P = 0.049) and FIB-4 at least 3.25 (0% CC, 3.8% CG, and 13.2% GG; P = 0.016). Furthermore, for each rs738409 G allele, the odds of having F at least 3 increased 2.15 times (95% confidence interval=1.07; 4.35; P = 0.029) and having FIB-4 at least 3.25 increased 8.77 times (95% of confidence interval = 1.11; 69.0; P = 0.039). Note that rs738409 G allele carriers tended to higher likelihood of having FPR at least 0.10, but statistical significance was not reached (P = 0.054). Finally, we did not find any association for A at least 3 and liver steatosis. CONCLUSION: PNPLA3 rs738409 polymorphism was associated with the severity of liver fibrosis in patients coinfected with HIV and hepatitis C virus, suggesting that this polymorphism might also play a significant role in the progression of hepatic fibrosis in this group of patients. SN - 1473-5571 UR - https://www.unboundmedicine.com/medline/citation/26760234/Impact_of_patatin_like_phospholipase_domain_containing_3_gene_polymorphism__rs738409__on_severity_of_liver_disease_in_HIV/hepatitis_C_virus_coinfected_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=26760234 DB - PRIME DP - Unbound Medicine ER -