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Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC.
Viruses. 2016 Jan 11; 8(1)V

Abstract

Rhinoviruses (RVs) and respiratory enteroviruses (EVs) are leading causes of upper respiratory tract infections and among the most frequent infectious agents in humans worldwide. Both are classified in the Enterovirus genus within the Picornaviridae family and they have been assigned to seven distinct species, RV-A, B, C and EV-A, B, C, D. As viral infections of public health significance, they represent an important financial burden on health systems worldwide. However, the lack of efficient antiviral treatment or vaccines against these highly prevalent pathogens prevents an effective management of RV-related diseases. Current advances in molecular diagnostic techniques have revealed the presence of RV in the lower respiratory tract and its role in lower airway diseases is increasingly reported. In addition to an established etiological role in the common cold, these viruses demonstrate an unexpected capacity to spread to other body sites under certain conditions. Some of these viruses have received particular attention recently, such as EV-D68 that caused a large outbreak of respiratory illness in 2014, respiratory EVs from species C, or viruses within the newly-discovered RV-C species. This review provides an update of the latest findings on clinical and fundamental aspects of RV and respiratory EV, including a summary of basic knowledge of their biology.

Authors+Show Affiliations

University of Geneva Faculty of Medicine, 1 Rue Michel-Servet, 1205 Geneva, Switzerland. lena.royston@hcuge.ch. Laboratory of Virology, Division of Infectious Diseases, University of Geneva Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland. lena.royston@hcuge.ch.University of Geneva Faculty of Medicine, 1 Rue Michel-Servet, 1205 Geneva, Switzerland. caroline.tapparel@hcuge.ch. Laboratory of Virology, Division of Infectious Diseases, University of Geneva Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland. caroline.tapparel@hcuge.ch.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26761027

Citation

Royston, Léna, and Caroline Tapparel. "Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC." Viruses, vol. 8, no. 1, 2016.
Royston L, Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016;8(1).
Royston, L., & Tapparel, C. (2016). Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses, 8(1). https://doi.org/10.3390/v8010016
Royston L, Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016 Jan 11;8(1) PubMed PMID: 26761027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. AU - Royston,Léna, AU - Tapparel,Caroline, Y1 - 2016/01/11/ PY - 2015/10/27/received PY - 2015/12/09/revised PY - 2015/12/28/accepted PY - 2016/1/14/entrez PY - 2016/1/14/pubmed PY - 2016/10/8/medline KW - common cold KW - enterovirus KW - evolution KW - pathogenesis KW - respiratory virus KW - rhinovirus JF - Viruses JO - Viruses VL - 8 IS - 1 N2 - Rhinoviruses (RVs) and respiratory enteroviruses (EVs) are leading causes of upper respiratory tract infections and among the most frequent infectious agents in humans worldwide. Both are classified in the Enterovirus genus within the Picornaviridae family and they have been assigned to seven distinct species, RV-A, B, C and EV-A, B, C, D. As viral infections of public health significance, they represent an important financial burden on health systems worldwide. However, the lack of efficient antiviral treatment or vaccines against these highly prevalent pathogens prevents an effective management of RV-related diseases. Current advances in molecular diagnostic techniques have revealed the presence of RV in the lower respiratory tract and its role in lower airway diseases is increasingly reported. In addition to an established etiological role in the common cold, these viruses demonstrate an unexpected capacity to spread to other body sites under certain conditions. Some of these viruses have received particular attention recently, such as EV-D68 that caused a large outbreak of respiratory illness in 2014, respiratory EVs from species C, or viruses within the newly-discovered RV-C species. This review provides an update of the latest findings on clinical and fundamental aspects of RV and respiratory EV, including a summary of basic knowledge of their biology. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/26761027/Rhinoviruses_and_Respiratory_Enteroviruses:_Not_as_Simple_as_ABC_ L2 - https://www.mdpi.com/resolver?pii=v8010016 DB - PRIME DP - Unbound Medicine ER -