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Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study.

Abstract

BACKGROUND AND AIMS

To better understand the metabolic syndrome (MS) spectrum through principal components analysis and further evaluate the role of the Mediterranean diet on MS presence.

METHODS

During 2001-2002, 1514 men and 1528 women (>18 y) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. MS was defined by the National Cholesterol Education Program Adult Treatment panel III (revised NCEP ATP III) definition. Adherence to the Mediterranean diet was assessed using the MedDietScore (range 0-55).

RESULTS

Five principal components were derived, explaining 73.8% of the total variation, characterized by the: a) body weight and lipid profile, b) blood pressure, c) lipid profile, d) glucose profile, e) inflammatory factors. All components were associated with higher likelihood of CVD incidence. After adjusting for various potential confounding factors, adherence to the Mediterranean dietary pattern for each 10% increase in the MedDietScore, was associated with 15% lower odds of CVD incidence (95%CI: 0.71-1.06). For the participants with low adherence to the Mediterranean diet all five components were significantly associated with increased likelihood of CVD incidence. However, for the ones following closely the Mediterranean pattern positive, yet not significant associations were observed.

CONCLUSION

Results of the present work propose a wider MS definition, while highlighting the beneficial role of the Mediterranean dietary pattern.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

    ,

    Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. Electronic address: d.b.panagiotakos@usa.net.

    ,

    First Cardiology Clinic, School of Medicine, University of Athens, Greece.

    ,

    Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

    ,

    Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.

    ,

    Laboratory of Biotechnologies Applied to Cardiovascular Medicine, Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatrical Sciences, University of Rome, Sapienza, Italy.

    ,

    First Cardiology Clinic, School of Medicine, University of Athens, Greece.

    ,

    First Cardiology Clinic, School of Medicine, University of Athens, Greece.

    ,

    First Cardiology Clinic, School of Medicine, University of Athens, Greece.

    Source

    Atherosclerosis 246: 2016 Mar pg 87-93

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Biomarkers
    Blood Glucose
    Blood Pressure
    Cardiovascular Diseases
    Diet, Mediterranean
    Female
    Follow-Up Studies
    Greece
    Humans
    Incidence
    Inflammation Mediators
    Lipids
    Logistic Models
    Male
    Metabolic Syndrome
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Patient Compliance
    Principal Component Analysis
    Protective Factors
    Risk Assessment
    Risk Factors
    Risk Reduction Behavior
    Time Factors
    Weight Gain
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26761772

    Citation

    Kastorini, Christina-Maria, et al. "Metabolic Syndrome, Adherence to the Mediterranean Diet and 10-year Cardiovascular Disease Incidence: the ATTICA Study." Atherosclerosis, vol. 246, 2016, pp. 87-93.
    Kastorini CM, Panagiotakos DB, Chrysohoou C, et al. Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study. Atherosclerosis. 2016;246:87-93.
    Kastorini, C. M., Panagiotakos, D. B., Chrysohoou, C., Georgousopoulou, E., Pitaraki, E., Puddu, P. E., ... Pitsavos, C. (2016). Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study. Atherosclerosis, 246, pp. 87-93. doi:10.1016/j.atherosclerosis.2015.12.025.
    Kastorini CM, et al. Metabolic Syndrome, Adherence to the Mediterranean Diet and 10-year Cardiovascular Disease Incidence: the ATTICA Study. Atherosclerosis. 2016;246:87-93. PubMed PMID: 26761772.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study. AU - Kastorini,Christina-Maria, AU - Panagiotakos,Demosthenes B, AU - Chrysohoou,Christina, AU - Georgousopoulou,Ekavi, AU - Pitaraki,Evangelia, AU - Puddu,Paolo Emilio, AU - Tousoulis,Dimitrios, AU - Stefanadis,Christodoulos, AU - Pitsavos,Christos, AU - ,, Y1 - 2015/12/18/ PY - 2015/09/06/received PY - 2015/10/21/revised PY - 2015/12/15/accepted PY - 2016/1/14/entrez PY - 2016/1/14/pubmed PY - 2016/12/15/medline KW - Cardiovascular disease KW - Incidence KW - Mediterranean diet KW - Metabolic syndrome SP - 87 EP - 93 JF - Atherosclerosis JO - Atherosclerosis VL - 246 N2 - BACKGROUND AND AIMS: To better understand the metabolic syndrome (MS) spectrum through principal components analysis and further evaluate the role of the Mediterranean diet on MS presence. METHODS: During 2001-2002, 1514 men and 1528 women (>18 y) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. MS was defined by the National Cholesterol Education Program Adult Treatment panel III (revised NCEP ATP III) definition. Adherence to the Mediterranean diet was assessed using the MedDietScore (range 0-55). RESULTS: Five principal components were derived, explaining 73.8% of the total variation, characterized by the: a) body weight and lipid profile, b) blood pressure, c) lipid profile, d) glucose profile, e) inflammatory factors. All components were associated with higher likelihood of CVD incidence. After adjusting for various potential confounding factors, adherence to the Mediterranean dietary pattern for each 10% increase in the MedDietScore, was associated with 15% lower odds of CVD incidence (95%CI: 0.71-1.06). For the participants with low adherence to the Mediterranean diet all five components were significantly associated with increased likelihood of CVD incidence. However, for the ones following closely the Mediterranean pattern positive, yet not significant associations were observed. CONCLUSION: Results of the present work propose a wider MS definition, while highlighting the beneficial role of the Mediterranean dietary pattern. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/26761772/Metabolic_syndrome_adherence_to_the_Mediterranean_diet_and_10_year_cardiovascular_disease_incidence:_The_ATTICA_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(15)30254-9 DB - PRIME DP - Unbound Medicine ER -