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Dietary flavonoid intake and incidence of erectile dysfunction.

Abstract

BACKGROUND

The predominant etiology for erectile dysfunction (ED) is vascular, but limited data are available on the role of diet. A higher intake of several flavonoids reduces diabetes and cardiovascular disease risk, but no studies have examined associations between flavonoids and erectile function.

OBJECTIVE

This study examined the relation between habitual flavonoid subclass intakes and incidence of ED.

DESIGN

We conducted a prospective study among 25,096 men from the Health Professionals Follow-Up Study. Total flavonoid and subclass intakes were calculated from food-frequency questionnaires collected every 4 y. Participants rated their erectile function in 2000 (with historical reporting from 1986) and again in 2004 and 2008.

RESULTS

During 10 y of follow-up, 35.6% reported incident ED. After multivariate adjustment, including classic cardiovascular disease risk factors, several subclasses were associated with reduced ED incidence, specifically flavones (RR = 0.91; 95% CI: 0.85, 0.97; P-trend = 0.006), flavanones (RR = 0.89; 95% CI: 0.83, 0.95; P-trend = 0.0009), and anthocyanins (RR = 0.91; 95% CI: 0.85, 0.98; P-trend = 0.002) comparing extreme intakes. The results remained statistically significant after additional adjustment for a composite dietary intake score. In analyses stratified by age, a higher intake of flavanones, anthocyanins, and flavones was significantly associated with a reduction in risk of ED only in men <70 y old and not older men (11-16% reduction in risk; P-interaction = 0.002, 0.03, and 0.007 for flavones, flavanones, and anthocyanins, respectively). In food-based analysis, higher total intake of fruit, a major source of anthocyanins and flavanones, was associated with a 14% reduction in risk of ED (RR = 0.86; 95% CI: 0.79, 0.92; P = 0.002).

CONCLUSIONS

These data suggest that a higher habitual intake of specific flavonoid-rich foods is associated with reduced ED incidence. Intervention trials are needed to further examine the impact of increasing intakes of commonly consumed flavonoid-rich foods on men's health.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom; Departments of.

    ,

    Nutrition and.

    Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital; and Harvard Medical School, Boston, MA erimm@hsph.harvard.edu.

    Source

    MeSH

    Age Factors
    Aged
    Anthocyanins
    Cohort Studies
    Diet
    Dietary Supplements
    Erectile Dysfunction
    Feeding Behavior
    Flavanones
    Flavones
    Flavonoids
    Follow-Up Studies
    Fruit
    Health Personnel
    Humans
    Incidence
    Male
    Middle Aged
    Nutrition Surveys
    Prospective Studies
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26762373

    Citation

    Cassidy, Aedín, et al. "Dietary Flavonoid Intake and Incidence of Erectile Dysfunction." The American Journal of Clinical Nutrition, vol. 103, no. 2, 2016, pp. 534-41.
    Cassidy A, Franz M, Rimm EB. Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr. 2016;103(2):534-41.
    Cassidy, A., Franz, M., & Rimm, E. B. (2016). Dietary flavonoid intake and incidence of erectile dysfunction. The American Journal of Clinical Nutrition, 103(2), pp. 534-41. doi:10.3945/ajcn.115.122010.
    Cassidy A, Franz M, Rimm EB. Dietary Flavonoid Intake and Incidence of Erectile Dysfunction. Am J Clin Nutr. 2016;103(2):534-41. PubMed PMID: 26762373.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary flavonoid intake and incidence of erectile dysfunction. AU - Cassidy,Aedín, AU - Franz,Mary, AU - Rimm,Eric B, Y1 - 2016/01/13/ PY - 2015/08/25/received PY - 2015/12/04/accepted PY - 2016/1/15/entrez PY - 2016/1/15/pubmed PY - 2016/6/14/medline KW - anthocyanins KW - erectile dysfunction KW - flavanones KW - flavones KW - flavonoids SP - 534 EP - 41 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 103 IS - 2 N2 - BACKGROUND: The predominant etiology for erectile dysfunction (ED) is vascular, but limited data are available on the role of diet. A higher intake of several flavonoids reduces diabetes and cardiovascular disease risk, but no studies have examined associations between flavonoids and erectile function. OBJECTIVE: This study examined the relation between habitual flavonoid subclass intakes and incidence of ED. DESIGN: We conducted a prospective study among 25,096 men from the Health Professionals Follow-Up Study. Total flavonoid and subclass intakes were calculated from food-frequency questionnaires collected every 4 y. Participants rated their erectile function in 2000 (with historical reporting from 1986) and again in 2004 and 2008. RESULTS: During 10 y of follow-up, 35.6% reported incident ED. After multivariate adjustment, including classic cardiovascular disease risk factors, several subclasses were associated with reduced ED incidence, specifically flavones (RR = 0.91; 95% CI: 0.85, 0.97; P-trend = 0.006), flavanones (RR = 0.89; 95% CI: 0.83, 0.95; P-trend = 0.0009), and anthocyanins (RR = 0.91; 95% CI: 0.85, 0.98; P-trend = 0.002) comparing extreme intakes. The results remained statistically significant after additional adjustment for a composite dietary intake score. In analyses stratified by age, a higher intake of flavanones, anthocyanins, and flavones was significantly associated with a reduction in risk of ED only in men <70 y old and not older men (11-16% reduction in risk; P-interaction = 0.002, 0.03, and 0.007 for flavones, flavanones, and anthocyanins, respectively). In food-based analysis, higher total intake of fruit, a major source of anthocyanins and flavanones, was associated with a 14% reduction in risk of ED (RR = 0.86; 95% CI: 0.79, 0.92; P = 0.002). CONCLUSIONS: These data suggest that a higher habitual intake of specific flavonoid-rich foods is associated with reduced ED incidence. Intervention trials are needed to further examine the impact of increasing intakes of commonly consumed flavonoid-rich foods on men's health. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26762373/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.122010 DB - PRIME DP - Unbound Medicine ER -