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IgA antibodies against phenolic glycolipid I from Mycobacterium leprae in serum of leprosy patients and contacts: subclass distribution and relation to disease activity.
Clin Immunol Immunopathol. 1989 Nov; 53(2 Pt 1):202-11.CI

Abstract

The anti-PGL-I IgA response against phenolic glycolipid I (PGL-I) a specific surface antigen of Mycobacterium leprae, was demonstrated to be essentially of the IgA1 subclass in sera from leprosy patients and contacts. Anti-PGL-I IgA1 mean levels were found to increase significantly from the tuberculoid toward the lepromatous pole of the leprosy disease spectrum, thus resembling the predominating anti-PGL-I IgM response. Furthermore, anti-PGL-I IgA1 values were shown to increase significantly with increasing bacillary load, measured as bacillary index (BI) from skin biopsies. However, a number of BI negative leprosy patients recorded elevated anti-PGL-I IgA1 levels possibly reflecting a persistence of disease activity. Three of 28 household or family contacts of leprosy patients were detected seropositive for anti-PGL-I IgA1. Thus, our results suggest that anti-PGL-I IgA1 may be considered as an additional parameter for the early detection of infection with M. leprae.

Authors+Show Affiliations

Neurological Institute, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2676273

Citation

Schwerer, B, et al. "IgA Antibodies Against Phenolic Glycolipid I From Mycobacterium Leprae in Serum of Leprosy Patients and Contacts: Subclass Distribution and Relation to Disease Activity." Clinical Immunology and Immunopathology, vol. 53, no. 2 Pt 1, 1989, pp. 202-11.
Schwerer B, Chujor CS, Bernheimer H, et al. IgA antibodies against phenolic glycolipid I from Mycobacterium leprae in serum of leprosy patients and contacts: subclass distribution and relation to disease activity. Clin Immunol Immunopathol. 1989;53(2 Pt 1):202-11.
Schwerer, B., Chujor, C. S., Bernheimer, H., Radl, J., Haaijman, J. J., Meeker, H. C., Sersen, G., & Levis, W. R. (1989). IgA antibodies against phenolic glycolipid I from Mycobacterium leprae in serum of leprosy patients and contacts: subclass distribution and relation to disease activity. Clinical Immunology and Immunopathology, 53(2 Pt 1), 202-11.
Schwerer B, et al. IgA Antibodies Against Phenolic Glycolipid I From Mycobacterium Leprae in Serum of Leprosy Patients and Contacts: Subclass Distribution and Relation to Disease Activity. Clin Immunol Immunopathol. 1989;53(2 Pt 1):202-11. PubMed PMID: 2676273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA antibodies against phenolic glycolipid I from Mycobacterium leprae in serum of leprosy patients and contacts: subclass distribution and relation to disease activity. AU - Schwerer,B, AU - Chujor,C S, AU - Bernheimer,H, AU - Radl,J, AU - Haaijman,J J, AU - Meeker,H C, AU - Sersen,G, AU - Levis,W R, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 202 EP - 11 JF - Clinical immunology and immunopathology JO - Clin Immunol Immunopathol VL - 53 IS - 2 Pt 1 N2 - The anti-PGL-I IgA response against phenolic glycolipid I (PGL-I) a specific surface antigen of Mycobacterium leprae, was demonstrated to be essentially of the IgA1 subclass in sera from leprosy patients and contacts. Anti-PGL-I IgA1 mean levels were found to increase significantly from the tuberculoid toward the lepromatous pole of the leprosy disease spectrum, thus resembling the predominating anti-PGL-I IgM response. Furthermore, anti-PGL-I IgA1 values were shown to increase significantly with increasing bacillary load, measured as bacillary index (BI) from skin biopsies. However, a number of BI negative leprosy patients recorded elevated anti-PGL-I IgA1 levels possibly reflecting a persistence of disease activity. Three of 28 household or family contacts of leprosy patients were detected seropositive for anti-PGL-I IgA1. Thus, our results suggest that anti-PGL-I IgA1 may be considered as an additional parameter for the early detection of infection with M. leprae. SN - 0090-1229 UR - https://www.unboundmedicine.com/medline/citation/2676273/IgA_antibodies_against_phenolic_glycolipid_I_from_Mycobacterium_leprae_in_serum_of_leprosy_patients_and_contacts:_subclass_distribution_and_relation_to_disease_activity_ DB - PRIME DP - Unbound Medicine ER -