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A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection.
Asian J Androl. 2017 Mar-Apr; 19(2):230-233.AJ

Abstract

In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) who underwent transurethral surgery. The study was conducted in 158 patients who came to our hospital for surgery. Clinical conditions were assessed by body mass index (BMI), digital rectal examination, International Prostate Symptom Score (IPSS) and transrectal ultrasound (TRUS). The levels of sex hormones (including total testosterone (TT), estradiol (E 2), progesterone (P), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL)) and prostate-specific antigen (PSA) were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 ± 8.68 years. The total IPSS was significantly associated with the TT level (r = -0.21, P= 0.01). Other sex hormone levels were not correlated with total IPSS. However, some ratios such as E 2 / TT (r = 0.23, P= 0.00) and FSH/LH (r = -0.17, P = 0.04) were associated with total IPSS. Further analysis showed that the nocturia was associated with age (r = 0.16, P= 0.04), BMI (r = 0.21, P = 0.01), and TT (r = -0.19, P= 0.02). Moreover, we divided the patients into two subgroups based on IPSS severity (<20 or ≥20). The mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study has shown that the severity of LUTS is associated with TT, E 2 / TT and FSH/LH in men who underwent prostate surgery. Increasing nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms.

Authors+Show Affiliations

Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Gynecology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.Department of Assisted Reproduction Medicine, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26763548

Citation

Wu, Yu, et al. "A Possible Relationship Between Serum Sex Hormones and Benign Prostatic Hyperplasia/lower Urinary Tract Symptoms in Men Who Underwent Transurethral Prostate Resection." Asian Journal of Andrology, vol. 19, no. 2, 2017, pp. 230-233.
Wu Y, Pan H, Wang WM, et al. A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection. Asian J Androl. 2017;19(2):230-233.
Wu, Y., Pan, H., Wang, W. M., Xu, D., Zhang, L., Gu, Z. Q., Bai, Q., Qi, J., & Huang, H. F. (2017). A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection. Asian Journal of Andrology, 19(2), 230-233. https://doi.org/10.4103/1008-682X.171575
Wu Y, et al. A Possible Relationship Between Serum Sex Hormones and Benign Prostatic Hyperplasia/lower Urinary Tract Symptoms in Men Who Underwent Transurethral Prostate Resection. Asian J Androl. 2017 Mar-Apr;19(2):230-233. PubMed PMID: 26763548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection. AU - Wu,Yu, AU - Pan,Hong, AU - Wang,Wei-Ming, AU - Xu,Ding, AU - Zhang,Liang, AU - Gu,Zheng-Qin, AU - Bai,Qiang, AU - Qi,Jun, AU - Huang,He-Feng, PY - 2017/03/01/pmc-release PY - 2016/1/15/pubmed PY - 2017/2/28/medline PY - 2016/1/15/entrez SP - 230 EP - 233 JF - Asian journal of andrology JO - Asian J Androl VL - 19 IS - 2 N2 - In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) who underwent transurethral surgery. The study was conducted in 158 patients who came to our hospital for surgery. Clinical conditions were assessed by body mass index (BMI), digital rectal examination, International Prostate Symptom Score (IPSS) and transrectal ultrasound (TRUS). The levels of sex hormones (including total testosterone (TT), estradiol (E 2), progesterone (P), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL)) and prostate-specific antigen (PSA) were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 ± 8.68 years. The total IPSS was significantly associated with the TT level (r = -0.21, P= 0.01). Other sex hormone levels were not correlated with total IPSS. However, some ratios such as E 2 / TT (r = 0.23, P= 0.00) and FSH/LH (r = -0.17, P = 0.04) were associated with total IPSS. Further analysis showed that the nocturia was associated with age (r = 0.16, P= 0.04), BMI (r = 0.21, P = 0.01), and TT (r = -0.19, P= 0.02). Moreover, we divided the patients into two subgroups based on IPSS severity (<20 or ≥20). The mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study has shown that the severity of LUTS is associated with TT, E 2 / TT and FSH/LH in men who underwent prostate surgery. Increasing nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms. SN - 1745-7262 UR - https://www.unboundmedicine.com/medline/citation/26763548/A_possible_relationship_between_serum_sex_hormones_and_benign_prostatic_hyperplasia/lower_urinary_tract_symptoms_in_men_who_underwent_transurethral_prostate_resection_ L2 - http://www.ajandrology.com/article.asp?issn=1008-682X;year=2017;volume=19;issue=2;spage=230;epage=233;aulast=Wu DB - PRIME DP - Unbound Medicine ER -