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The Relationship Between Body Iron Status, Iron Intake And Gestational Diabetes: A Systematic Review and Meta-Analysis.

Abstract

Biological and epidemiological evidence have found that gestational diabetes mellitus (GDM) may be correlated with body iron status and dietary iron intake. Therefore, we investigated the relationship between dietary iron intake and body iron status and GDM risk.We conducted a systematic search in Embase, PubMed, Web of Science, and Cochrane Library up to April 2015. Prospective cohort studies or case-control studies which appraised the relationship between body iron status, dietary iron intake, and GDM risk were included. Relative risks (RRs), standard mean difference (SMD), and 95% confidence intervals [CIs] were used to measure the pooled data.A total of 8 prospective cohort studies and 7 case-control studies were in accordance with inclusive criteria, and 14 studies were included in meta-analysis. The overall RR comparing the highest and lowest levels of serum ferritin was 3.22 (95% CI: 1.73-6.00) for prospective cohort studies. Serum ferritin of GDM group is markedly higher than that of control (0.88 ng/mL; 95% CI: 0.40-1.35 ng/mL) for case-control studies. The comparison between the highest and the lowest serum ferritin levels and dietary total iron levels revealed pooled RRs of 1.53 (95% CI: 1.17-2.00) and 1.01 (95% CI: 1.00-1.01) for prospective cohort studies, respectively. The combined SMD comparing serum transferrin levels of cases and controls was -0.02 μmol/L (95% CI: -0.22 to 0.19 μmol/L) for case-control studies.Increased higher ferritin levels were significantly correlated with higher risk of GDM, and higher heme iron levels may be correlated with higher risk of GDM; however, the present conclusion did not constitute definitive proof that dietary total iron or serum transferrin have relation to GDM.

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  • Authors+Show Affiliations

    ,

    From the Department of Endocrinology (SF, FL, ZL), The First Affiliated Hospital of Chongqing Medical University, Chongqing; and Department of Oncology (JZ), Affiliated Hospital of Zunyi Medical University, Guizhou, China.

    , ,

    Source

    Medicine 95:2 2016 Jan pg e2383

    MeSH

    Diabetes, Gestational
    Female
    Ferritins
    Humans
    Iron
    Iron, Dietary
    Pregnancy

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    26765415

    Citation

    Fu, Shimin, et al. "The Relationship Between Body Iron Status, Iron Intake and Gestational Diabetes: a Systematic Review and Meta-Analysis." Medicine, vol. 95, no. 2, 2016, pp. e2383.
    Fu S, Li F, Zhou J, et al. The Relationship Between Body Iron Status, Iron Intake And Gestational Diabetes: A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2016;95(2):e2383.
    Fu, S., Li, F., Zhou, J., & Liu, Z. (2016). The Relationship Between Body Iron Status, Iron Intake And Gestational Diabetes: A Systematic Review and Meta-Analysis. Medicine, 95(2), pp. e2383. doi:10.1097/MD.0000000000002383.
    Fu S, et al. The Relationship Between Body Iron Status, Iron Intake and Gestational Diabetes: a Systematic Review and Meta-Analysis. Medicine (Baltimore). 2016;95(2):e2383. PubMed PMID: 26765415.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Relationship Between Body Iron Status, Iron Intake And Gestational Diabetes: A Systematic Review and Meta-Analysis. AU - Fu,Shimin, AU - Li,Feifei, AU - Zhou,Jianguo, AU - Liu,Zhiping, PY - 2016/1/15/entrez PY - 2016/1/15/pubmed PY - 2016/5/26/medline SP - e2383 EP - e2383 JF - Medicine JO - Medicine (Baltimore) VL - 95 IS - 2 N2 - Biological and epidemiological evidence have found that gestational diabetes mellitus (GDM) may be correlated with body iron status and dietary iron intake. Therefore, we investigated the relationship between dietary iron intake and body iron status and GDM risk.We conducted a systematic search in Embase, PubMed, Web of Science, and Cochrane Library up to April 2015. Prospective cohort studies or case-control studies which appraised the relationship between body iron status, dietary iron intake, and GDM risk were included. Relative risks (RRs), standard mean difference (SMD), and 95% confidence intervals [CIs] were used to measure the pooled data.A total of 8 prospective cohort studies and 7 case-control studies were in accordance with inclusive criteria, and 14 studies were included in meta-analysis. The overall RR comparing the highest and lowest levels of serum ferritin was 3.22 (95% CI: 1.73-6.00) for prospective cohort studies. Serum ferritin of GDM group is markedly higher than that of control (0.88 ng/mL; 95% CI: 0.40-1.35 ng/mL) for case-control studies. The comparison between the highest and the lowest serum ferritin levels and dietary total iron levels revealed pooled RRs of 1.53 (95% CI: 1.17-2.00) and 1.01 (95% CI: 1.00-1.01) for prospective cohort studies, respectively. The combined SMD comparing serum transferrin levels of cases and controls was -0.02 μmol/L (95% CI: -0.22 to 0.19 μmol/L) for case-control studies.Increased higher ferritin levels were significantly correlated with higher risk of GDM, and higher heme iron levels may be correlated with higher risk of GDM; however, the present conclusion did not constitute definitive proof that dietary total iron or serum transferrin have relation to GDM. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/26765415/The_Relationship_Between_Body_Iron_Status_Iron_Intake_And_Gestational_Diabetes:_A_Systematic_Review_and_Meta_Analysis_ L2 - http://Insights.ovid.com/pubmed?pmid=26765415 DB - PRIME DP - Unbound Medicine ER -