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Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse.
Sex Transm Dis. 2016 Feb; 43(2):105-9.ST

Abstract

BACKGROUND

Screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in men who have sex with men is risk based. Despite high frequencies of oral and receptive anal intercourse (RAI) among women, extragenital screening is not recommended.

METHODS

Women (n = 175) and men who have sex with men (n = 224) primarily recruited from a sexually transmitted infection clinic reporting a lifetime history of RAI completed a structured questionnaire and clinician-collected swab samples from the rectum, pharynx, vagina (women), and urine (men). CT and GC were detected using 2 commercial nucleic acid amplification tests (Aptima Combo 2; Hologic, Inc, Bedford, MA; Xpert CT/NG, Cepheid Innovation, Sunnyvale, CA).

RESULTS

The median age of the population was 26 years, 62% were white, and 88% were enrolled from a sexually transmitted disease clinic. Men were more likely than women to have GC (22.8% vs. 3.4%) and CT (21.9% vs. 12.6%). In men versus women, GC was detected in 16.5% versus 2.3% of pharyngeal swabs, 11.6% versus 2.3% of rectal swabs, and 5.4% versus 2.9% of urine samples or vaginal swabs. C. trachomatis was detected in 2.2% versus 1.7% of pharyngeal swabs, 17.4% versus 11.4% of rectal swabs, and 4.5% versus 10.3% for urogenital sites in men versus women. Overall 79.6% of CT and 76.5% of GC in men and 18.2% of CT and 16.7% of GC in women were detected only in the pharynx or rectum.

CONCLUSION

Reliance on urogenital screening alone misses most of GC and CT in men and more than 15% of infections in women reporting RAI.

Authors+Show Affiliations

From the *University of Pittsburgh, Pittsburgh, PA; and †Magee-Womens Research Institute, Pittsburgh, PA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26766527

Citation

Danby, Claire S., et al. "Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse." Sexually Transmitted Diseases, vol. 43, no. 2, 2016, pp. 105-9.
Danby CS, Cosentino LA, Rabe LK, et al. Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse. Sex Transm Dis. 2016;43(2):105-9.
Danby, C. S., Cosentino, L. A., Rabe, L. K., Priest, C. L., Damare, K. C., Macio, I. S., Meyn, L. A., Wiesenfeld, H. C., & Hillier, S. L. (2016). Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse. Sexually Transmitted Diseases, 43(2), 105-9. https://doi.org/10.1097/OLQ.0000000000000384
Danby CS, et al. Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse. Sex Transm Dis. 2016;43(2):105-9. PubMed PMID: 26766527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse. AU - Danby,Claire S, AU - Cosentino,Lisa A, AU - Rabe,Lorna K, AU - Priest,Carol L, AU - Damare,Khrystine C, AU - Macio,Ingrid S, AU - Meyn,Leslie A, AU - Wiesenfeld,Harold C, AU - Hillier,Sharon L, PY - 2016/1/15/entrez PY - 2016/1/15/pubmed PY - 2016/12/15/medline SP - 105 EP - 9 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 43 IS - 2 N2 - BACKGROUND: Screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in men who have sex with men is risk based. Despite high frequencies of oral and receptive anal intercourse (RAI) among women, extragenital screening is not recommended. METHODS: Women (n = 175) and men who have sex with men (n = 224) primarily recruited from a sexually transmitted infection clinic reporting a lifetime history of RAI completed a structured questionnaire and clinician-collected swab samples from the rectum, pharynx, vagina (women), and urine (men). CT and GC were detected using 2 commercial nucleic acid amplification tests (Aptima Combo 2; Hologic, Inc, Bedford, MA; Xpert CT/NG, Cepheid Innovation, Sunnyvale, CA). RESULTS: The median age of the population was 26 years, 62% were white, and 88% were enrolled from a sexually transmitted disease clinic. Men were more likely than women to have GC (22.8% vs. 3.4%) and CT (21.9% vs. 12.6%). In men versus women, GC was detected in 16.5% versus 2.3% of pharyngeal swabs, 11.6% versus 2.3% of rectal swabs, and 5.4% versus 2.9% of urine samples or vaginal swabs. C. trachomatis was detected in 2.2% versus 1.7% of pharyngeal swabs, 17.4% versus 11.4% of rectal swabs, and 4.5% versus 10.3% for urogenital sites in men versus women. Overall 79.6% of CT and 76.5% of GC in men and 18.2% of CT and 16.7% of GC in women were detected only in the pharynx or rectum. CONCLUSION: Reliance on urogenital screening alone misses most of GC and CT in men and more than 15% of infections in women reporting RAI. SN - 1537-4521 UR - https://www.unboundmedicine.com/medline/citation/26766527/Patterns_of_Extragenital_Chlamydia_and_Gonorrhea_in_Women_and_Men_Who_Have_Sex_With_Men_Reporting_a_History_of_Receptive_Anal_Intercourse_ L2 - https://doi.org/10.1097/OLQ.0000000000000384 DB - PRIME DP - Unbound Medicine ER -