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Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM.
Diabetes. 1989 Oct; 38(10):1314-9.D

Abstract

Fish oils, containing omega-3 fatty acids (omega 3FAs), favorably influence plasma lipoproteins in nondiabetic humans and prevent the development of insulin resistance induced by fat feeding in rats. We studied the effects of fish oils in 10 subjects (aged 42-65 yr) with mild non-insulin-dependent diabetes mellitus (NIDDM). Subjects were fed a standard diabetic diet plus 1) no supplementation (baseline), 2) 10 g fish oil concentrate (30% omega 3FAs) daily, and 3) 10 g safflower oil daily over separate 3-wk periods, the latter two supplements being given in radom order by use of a double-blind crossover design. At the end of each diet period, fasting blood glucose (FBG), insulin, and lipids were measured, and insulin sensitivity was assessed with a hyperinsulinemic-euglycemic clamp performed with [3-3H]glucose. FBG increased 14% during fish oil and 11% during safflower oil supplementation compared with baseline (P less than .05), whereas body weight, fasting serum insulin levels, and insulin sensitivity were unchanged. The absolute increase in FBG during each supplementation period correlated with the baseline FBG (fish oil, r = .83, P less than .005); safflower oil, r = .75, P = .012). Fasting plasma triglyceride levels decreased during fish oil supplementation in the 4 subjects with baseline hypertriglyceridemia (greater than 2 mM) but were not significantly reduced overall. There was no significant change in fasting plasma total, high-density lipoprotein, and low-density lipoprotein cholesterol levels. In summary, dietary fish oil supplementation adversely affected glycemic control in NIDDM subjects without producing significant beneficial effects on plasma lipids. The effect of safflower oil supplementation was not significantly different from fish oil, suggesting that the negative effects on glucose metabolism may be related to the extra energy or fat intake.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Garvan Institute of Medical Research St. Vincent's Hospital, Sydney New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2676659

Citation

Borkman, M, et al. "Effects of Fish Oil Supplementation On Glucose and Lipid Metabolism in NIDDM." Diabetes, vol. 38, no. 10, 1989, pp. 1314-9.
Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes. 1989;38(10):1314-9.
Borkman, M., Chisholm, D. J., Furler, S. M., Storlien, L. H., Kraegen, E. W., Simons, L. A., & Chesterman, C. N. (1989). Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes, 38(10), 1314-9.
Borkman M, et al. Effects of Fish Oil Supplementation On Glucose and Lipid Metabolism in NIDDM. Diabetes. 1989;38(10):1314-9. PubMed PMID: 2676659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. AU - Borkman,M, AU - Chisholm,D J, AU - Furler,S M, AU - Storlien,L H, AU - Kraegen,E W, AU - Simons,L A, AU - Chesterman,C N, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 1314 EP - 9 JF - Diabetes JO - Diabetes VL - 38 IS - 10 N2 - Fish oils, containing omega-3 fatty acids (omega 3FAs), favorably influence plasma lipoproteins in nondiabetic humans and prevent the development of insulin resistance induced by fat feeding in rats. We studied the effects of fish oils in 10 subjects (aged 42-65 yr) with mild non-insulin-dependent diabetes mellitus (NIDDM). Subjects were fed a standard diabetic diet plus 1) no supplementation (baseline), 2) 10 g fish oil concentrate (30% omega 3FAs) daily, and 3) 10 g safflower oil daily over separate 3-wk periods, the latter two supplements being given in radom order by use of a double-blind crossover design. At the end of each diet period, fasting blood glucose (FBG), insulin, and lipids were measured, and insulin sensitivity was assessed with a hyperinsulinemic-euglycemic clamp performed with [3-3H]glucose. FBG increased 14% during fish oil and 11% during safflower oil supplementation compared with baseline (P less than .05), whereas body weight, fasting serum insulin levels, and insulin sensitivity were unchanged. The absolute increase in FBG during each supplementation period correlated with the baseline FBG (fish oil, r = .83, P less than .005); safflower oil, r = .75, P = .012). Fasting plasma triglyceride levels decreased during fish oil supplementation in the 4 subjects with baseline hypertriglyceridemia (greater than 2 mM) but were not significantly reduced overall. There was no significant change in fasting plasma total, high-density lipoprotein, and low-density lipoprotein cholesterol levels. In summary, dietary fish oil supplementation adversely affected glycemic control in NIDDM subjects without producing significant beneficial effects on plasma lipids. The effect of safflower oil supplementation was not significantly different from fish oil, suggesting that the negative effects on glucose metabolism may be related to the extra energy or fat intake.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/2676659/Effects_of_fish_oil_supplementation_on_glucose_and_lipid_metabolism_in_NIDDM_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&pmid=2676659 DB - PRIME DP - Unbound Medicine ER -