Tags

Type your tag names separated by a space and hit enter

Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia.
Aging Clin Exp Res. 2016 Dec; 28(6):1075-1079.AC

Abstract

OBJECTIVE

The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia.

METHODS

The cognitive functions of 98 elderly patients who were scheduled to undergo selective hip replacement surgery under general anesthesia were assessed using the Montreal Cognitive Assessment (MoCA) 3 days before surgery and on postoperative Days 1, 2, 3, and 7. The serum levels of ADP and MMP-9 were determined at the same time points, and the presence of POCD on postoperative Day 3 was recorded. The patients were divided into a POCD group and non-POCD group.

RESULTS

Postoperative cognitive dysfunction was observed in 28 patients (28.5 %). Serum MMP-9 levels significantly increased and serum ADP levels significantly decreased in the POCD group at each postoperative time point and in the non-POCD group on postoperative Days 1 and 2 compared to the presurgical levels. Serum MMP-9 levels were significantly higher and serum ADP levels were significantly lower in the POCD group compared with those in the non-POCD group at each time point. In the POCD patients, serum MMP-9 levels were significantly and negatively correlated and serum ADP levels were significantly and positively correlated with the MoCA scores.

CONCLUSIONS

The increased serum MMP-9 levels and decreased serum ADP levels in elderly patients after general anesthesia might be involved in the POCD pathophysiological process.

Authors+Show Affiliations

Department of Anesthesiology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China. haihuixiecn@126.com.Department of Anesthesiology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.Department of Anesthesiology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.Department of Anesthesiology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.Department of Osteology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.Department of Osteology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.Department of Anesthesiology, Dongguan People's Hospital, Dongguan, 5230181, Guangdong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26768000

Citation

Xie, Haihui, et al. "Relationships Between Adiponectin and Matrix Metalloproteinase-9 (MMP-9) Serum Levels and Postoperative Cognitive Dysfunction in Elderly Patients After General Anesthesia." Aging Clinical and Experimental Research, vol. 28, no. 6, 2016, pp. 1075-1079.
Xie H, Huang D, Zhang S, et al. Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia. Aging Clin Exp Res. 2016;28(6):1075-1079.
Xie, H., Huang, D., Zhang, S., Hu, X., Guo, J., Wang, Z., & Zhou, G. (2016). Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia. Aging Clinical and Experimental Research, 28(6), 1075-1079.
Xie H, et al. Relationships Between Adiponectin and Matrix Metalloproteinase-9 (MMP-9) Serum Levels and Postoperative Cognitive Dysfunction in Elderly Patients After General Anesthesia. Aging Clin Exp Res. 2016;28(6):1075-1079. PubMed PMID: 26768000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia. AU - Xie,Haihui, AU - Huang,Dehui, AU - Zhang,Shu, AU - Hu,Xiaoming, AU - Guo,Jianer, AU - Wang,Zaiguo, AU - Zhou,Guilan, Y1 - 2016/01/14/ PY - 2015/07/23/received PY - 2015/12/18/accepted PY - 2016/1/16/pubmed PY - 2017/1/5/medline PY - 2016/1/16/entrez KW - Adiponectin KW - General anesthesia KW - Matrix metalloproteinase-9 KW - Postoperative cognitive dysfunction KW - The elderly SP - 1075 EP - 1079 JF - Aging clinical and experimental research JO - Aging Clin Exp Res VL - 28 IS - 6 N2 - OBJECTIVE: The aim of this study was to evaluate the relationships between the serum levels of adiponectin (ADP) and matrix metalloproteinase-9 (MMP-9) and postoperative cognitive dysfunction (POCD) in elderly patients after general anesthesia. METHODS: The cognitive functions of 98 elderly patients who were scheduled to undergo selective hip replacement surgery under general anesthesia were assessed using the Montreal Cognitive Assessment (MoCA) 3 days before surgery and on postoperative Days 1, 2, 3, and 7. The serum levels of ADP and MMP-9 were determined at the same time points, and the presence of POCD on postoperative Day 3 was recorded. The patients were divided into a POCD group and non-POCD group. RESULTS: Postoperative cognitive dysfunction was observed in 28 patients (28.5 %). Serum MMP-9 levels significantly increased and serum ADP levels significantly decreased in the POCD group at each postoperative time point and in the non-POCD group on postoperative Days 1 and 2 compared to the presurgical levels. Serum MMP-9 levels were significantly higher and serum ADP levels were significantly lower in the POCD group compared with those in the non-POCD group at each time point. In the POCD patients, serum MMP-9 levels were significantly and negatively correlated and serum ADP levels were significantly and positively correlated with the MoCA scores. CONCLUSIONS: The increased serum MMP-9 levels and decreased serum ADP levels in elderly patients after general anesthesia might be involved in the POCD pathophysiological process. SN - 1720-8319 UR - https://www.unboundmedicine.com/medline/citation/26768000/Relationships_between_adiponectin_and_matrix_metalloproteinase_9__MMP_9__serum_levels_and_postoperative_cognitive_dysfunction_in_elderly_patients_after_general_anesthesia_ L2 - https://dx.doi.org/10.1007/s40520-015-0519-9 DB - PRIME DP - Unbound Medicine ER -