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Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells.
Angew Chem Int Ed Engl. 2015 Nov 23; 54(48):14402-6.AC

Abstract

Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO2 to form a sandwiching RGO@TiO2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs-RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.

Authors+Show Affiliations

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China).Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (China). whhuang@whu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26768108

Citation

Xu, Jia-Quan, et al. "Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells." Angewandte Chemie (International Ed. in English), vol. 54, no. 48, 2015, pp. 14402-6.
Xu JQ, Liu YL, Wang Q, et al. Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells. Angew Chem Int Ed Engl. 2015;54(48):14402-6.
Xu, J. Q., Liu, Y. L., Wang, Q., Duo, H. H., Zhang, X. W., Li, Y. T., & Huang, W. H. (2015). Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells. Angewandte Chemie (International Ed. in English), 54(48), 14402-6. https://doi.org/10.1002/anie.201507354
Xu JQ, et al. Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells. Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14402-6. PubMed PMID: 26768108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells. AU - Xu,Jia-Quan, AU - Liu,Yan-Ling, AU - Wang,Qian, AU - Duo,Huan-Huan, AU - Zhang,Xin-Wei, AU - Li,Yu-Tao, AU - Huang,Wei-Hua, Y1 - 2015/10/02/ PY - 2015/08/07/received PY - 2015/09/09/revised PY - 2016/1/16/entrez PY - 2016/1/16/pubmed PY - 2016/10/1/medline KW - electrochemistry KW - nitric oxide KW - photocatalytic cleaning KW - recyclable detection KW - renewable electrochemical sensors SP - 14402 EP - 6 JF - Angewandte Chemie (International ed. in English) JO - Angew. Chem. Int. Ed. Engl. VL - 54 IS - 48 N2 - Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO2 to form a sandwiching RGO@TiO2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs-RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/26768108/Photocatalytically_Renewable_Micro_electrochemical_Sensor_for_Real_Time_Monitoring_of_Cells_ L2 - https://doi.org/10.1002/anie.201507354 DB - PRIME DP - Unbound Medicine ER -