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Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People.
Stroke. 2016 Feb; 47(2):516-8.S

Abstract

BACKGROUND AND PURPOSE

Although several forms of sleep disruption are associated with stroke, few studies have examined the relationship between sleep and histopathologic measures of cerebrovascular disease. We tested the hypothesis that greater sleep fragmentation is associated with a higher burden of cerebral vessel and infarct pathology at autopsy.

METHODS

We used ordinal logistic regression models to relate sleep fragmentation measured by actigraphy to the severity of arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy, and the number of macroscopic and microscopic infarcts assessed by structured brain autopsy in 315 participants from the Rush Memory and Aging Project.

RESULTS

Greater sleep fragmentation was associated with more severe arteriolosclerosis (odds ratio, 1.27; 95% confidence interval, 1.02-1.59; P=0.03 per 1 SD greater sleep fragmentation) and more subcortical macroscopic infarcts (odds ratio, 1.31; 95% confidence interval, 1.01-1.68; P=0.04). These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities.

CONCLUSIONS

Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults.

Authors+Show Affiliations

From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL. andrew.lim@utoronto.ca.From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.From the Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada (A.S.P.L.); Department of Neurological Sciences, Rush Alzheimer's Disease Center (L.Y., J.A.S., D.A.B., A.S.B.) and Department of Pathology (J.A.S.), Rush University, Chicago, IL.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26768207

Citation

Lim, Andrew S P., et al. "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People." Stroke, vol. 47, no. 2, 2016, pp. 516-8.
Lim AS, Yu L, Schneider JA, et al. Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke. 2016;47(2):516-8.
Lim, A. S., Yu, L., Schneider, J. A., Bennett, D. A., & Buchman, A. S. (2016). Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke, 47(2), 516-8. https://doi.org/10.1161/STROKEAHA.115.011608
Lim AS, et al. Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke. 2016;47(2):516-8. PubMed PMID: 26768207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. AU - Lim,Andrew S P, AU - Yu,Lei, AU - Schneider,Julie A, AU - Bennett,David A, AU - Buchman,Aron S, Y1 - 2016/01/14/ PY - 2015/09/23/received PY - 2015/11/10/accepted PY - 2016/1/16/entrez PY - 2016/1/16/pubmed PY - 2016/6/10/medline KW - arteriolosclerosis KW - cerebral infarct KW - histopathology KW - sleep KW - stroke SP - 516 EP - 8 JF - Stroke JO - Stroke VL - 47 IS - 2 N2 - BACKGROUND AND PURPOSE: Although several forms of sleep disruption are associated with stroke, few studies have examined the relationship between sleep and histopathologic measures of cerebrovascular disease. We tested the hypothesis that greater sleep fragmentation is associated with a higher burden of cerebral vessel and infarct pathology at autopsy. METHODS: We used ordinal logistic regression models to relate sleep fragmentation measured by actigraphy to the severity of arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy, and the number of macroscopic and microscopic infarcts assessed by structured brain autopsy in 315 participants from the Rush Memory and Aging Project. RESULTS: Greater sleep fragmentation was associated with more severe arteriolosclerosis (odds ratio, 1.27; 95% confidence interval, 1.02-1.59; P=0.03 per 1 SD greater sleep fragmentation) and more subcortical macroscopic infarcts (odds ratio, 1.31; 95% confidence interval, 1.01-1.68; P=0.04). These associations were independent of established cardiovascular risk factors and diseases, and several medical comorbidities. CONCLUSIONS: Sleep fragmentation is associated with arteriolosclerosis and subcortical infarcts in older adults. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/26768207/Sleep_Fragmentation_Cerebral_Arteriolosclerosis_and_Brain_Infarct_Pathology_in_Community_Dwelling_Older_People_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.115.011608?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -