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Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons.
Biochim Biophys Acta 2016; 1862(5):878-86BB

Abstract

There is growing evidence suggesting that vascular pathologies and dysfunction play a critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular pathologies such as macroinfarcts, microinfarcts, microbleeds, small and large vessel cerebrovascular disease, and white matter disease are common especially in the brains of older persons where they contribute to cognitive impairment and lower the dementia threshold. Vascular dysfunction resulting in decreased cerebral blood flow, and abnormalities in the blood brain barrier may also contribute to the Alzheimer's disease (AD) pathophysiologic process and AD dementia. This review provides a clinical-pathological perspective on the role of vessel disease, vascular brain injury, alterations of the neurovascular unit, and mixed pathologies in the Alzheimer's disease pathophysiologic process and Alzheimer's dementia. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina Street, IL 60612, Chicago, USA. Electronic address: Alifiya_Kapasi@rush.edu.Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina Street, IL 60612, Chicago, USA. Electronic address: Julie_A_Schneider@rush.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

26769363

Citation

Kapasi, A, and J A. Schneider. "Vascular Contributions to Cognitive Impairment, Clinical Alzheimer's Disease, and Dementia in Older Persons." Biochimica Et Biophysica Acta, vol. 1862, no. 5, 2016, pp. 878-86.
Kapasi A, Schneider JA. Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. Biochim Biophys Acta. 2016;1862(5):878-86.
Kapasi, A., & Schneider, J. A. (2016). Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. Biochimica Et Biophysica Acta, 1862(5), pp. 878-86. doi:10.1016/j.bbadis.2015.12.023.
Kapasi A, Schneider JA. Vascular Contributions to Cognitive Impairment, Clinical Alzheimer's Disease, and Dementia in Older Persons. Biochim Biophys Acta. 2016;1862(5):878-86. PubMed PMID: 26769363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. AU - Kapasi,A, AU - Schneider,J A, Y1 - 2016/01/05/ PY - 2015/11/03/received PY - 2015/12/29/revised PY - 2015/12/29/accepted PY - 2016/1/16/entrez PY - 2016/1/16/pubmed PY - 2019/1/25/medline KW - Alzheimer's disease KW - Dementia KW - Mixed pathologies KW - Neuropathology KW - Vascular SP - 878 EP - 86 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1862 IS - 5 N2 - There is growing evidence suggesting that vascular pathologies and dysfunction play a critical role in cognitive impairment, clinical Alzheimer's disease, and dementia. Vascular pathologies such as macroinfarcts, microinfarcts, microbleeds, small and large vessel cerebrovascular disease, and white matter disease are common especially in the brains of older persons where they contribute to cognitive impairment and lower the dementia threshold. Vascular dysfunction resulting in decreased cerebral blood flow, and abnormalities in the blood brain barrier may also contribute to the Alzheimer's disease (AD) pathophysiologic process and AD dementia. This review provides a clinical-pathological perspective on the role of vessel disease, vascular brain injury, alterations of the neurovascular unit, and mixed pathologies in the Alzheimer's disease pathophysiologic process and Alzheimer's dementia. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26769363/Vascular_contributions_to_cognitive_impairment_clinical_Alzheimer's_disease_and_dementia_in_older_persons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(15)00387-7 DB - PRIME DP - Unbound Medicine ER -