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Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation.
Korean J Pediatr 2015; 58(12):459-65KJ

Abstract

Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies focused on obtaining serial measurements of lung function in infants and toddlers with a risk of bronchiolitis obliterans (BO) after lower respiratory tract infection are therefore needed. Although an optimal treatment for PIBO has not been established, corticosteroids have been used to target the inflammatory component. Other treatment modalities for BO after lung transplantation or hematopoietic stem cell transplantation have been studied in clinical trials, and the results can be extrapolated for the treatment of PIBO. Lung transplantation remains the final option for children with PIBO who have progressed to end-stage lung disease.

Authors+Show Affiliations

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26770220

Citation

Yu, Jinho. "Postinfectious Bronchiolitis Obliterans in Children: Lessons From Bronchiolitis Obliterans After Lung Transplantation and Hematopoietic Stem Cell Transplantation." Korean Journal of Pediatrics, vol. 58, no. 12, 2015, pp. 459-65.
Yu J. Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean J Pediatr. 2015;58(12):459-65.
Yu, J. (2015). Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean Journal of Pediatrics, 58(12), pp. 459-65. doi:10.3345/kjp.2015.58.12.459.
Yu J. Postinfectious Bronchiolitis Obliterans in Children: Lessons From Bronchiolitis Obliterans After Lung Transplantation and Hematopoietic Stem Cell Transplantation. Korean J Pediatr. 2015;58(12):459-65. PubMed PMID: 26770220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. A1 - Yu,Jinho, Y1 - 2015/12/22/ PY - 2015/02/20/received PY - 2015/06/13/accepted PY - 2016/1/16/entrez PY - 2016/1/16/pubmed PY - 2016/1/16/medline KW - Bronchiolitis obliterans KW - Child KW - Fibrosis KW - Inflammation KW - Post-infectious SP - 459 EP - 65 JF - Korean journal of pediatrics JO - Korean J Pediatr VL - 58 IS - 12 N2 - Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood. Further studies focused on obtaining serial measurements of lung function in infants and toddlers with a risk of bronchiolitis obliterans (BO) after lower respiratory tract infection are therefore needed. Although an optimal treatment for PIBO has not been established, corticosteroids have been used to target the inflammatory component. Other treatment modalities for BO after lung transplantation or hematopoietic stem cell transplantation have been studied in clinical trials, and the results can be extrapolated for the treatment of PIBO. Lung transplantation remains the final option for children with PIBO who have progressed to end-stage lung disease. SN - 1738-1061 UR - https://www.unboundmedicine.com/medline/citation/26770220/Postinfectious_bronchiolitis_obliterans_in_children:_lessons_from_bronchiolitis_obliterans_after_lung_transplantation_and_hematopoietic_stem_cell_transplantation_ L2 - https://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2015.58.12.459 DB - PRIME DP - Unbound Medicine ER -