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History of chemotherapy of leprosy.
Clin Dermatol. 2016 Jan-Feb; 34(1):32-6.CD

Abstract

Chemotherapy of leprosy over the past 70 years has passed through several phases, from sulfones, to clofazimine, and to highly bactericidal drugs like rifampicin. The use particularly of the more potent drugs in effective combinations and the development of standard multidrug therapy regimens have made a huge difference in the successful treatment of leprosy as well as in reducing tremendously the prevalence of leprosy globally. A major contributing factor to development of better drugs and drug combinations has been the introduction of the mouse footpad model to evaluate the in vivo activity of drugs against Mycobacterium leprae. The World Health Organization has recommended multidrug therapy, which has been used to treat more than 15 million patients in the last 30 years and has set an excellent record with regard to its very high rate of cure, very low occurrence of relapse, and very rare occurrence of drug resistance.

Authors+Show Affiliations

Former Director, Action Programme for Elimination of Leprosy, World Health Organization, Geneva, Switzerland. Electronic address: Noordeen@eth.net.

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

26773621

Citation

Noordeen, Shaik K.. "History of Chemotherapy of Leprosy." Clinics in Dermatology, vol. 34, no. 1, 2016, pp. 32-6.
Noordeen SK. History of chemotherapy of leprosy. Clin Dermatol. 2016;34(1):32-6.
Noordeen, S. K. (2016). History of chemotherapy of leprosy. Clinics in Dermatology, 34(1), 32-6. https://doi.org/10.1016/j.clindermatol.2015.10.016
Noordeen SK. History of Chemotherapy of Leprosy. Clin Dermatol. 2016 Jan-Feb;34(1):32-6. PubMed PMID: 26773621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - History of chemotherapy of leprosy. A1 - Noordeen,Shaik K, Y1 - 2015/10/28/ PY - 2016/1/17/entrez PY - 2016/1/17/pubmed PY - 2016/10/21/medline SP - 32 EP - 6 JF - Clinics in dermatology JO - Clin. Dermatol. VL - 34 IS - 1 N2 - Chemotherapy of leprosy over the past 70 years has passed through several phases, from sulfones, to clofazimine, and to highly bactericidal drugs like rifampicin. The use particularly of the more potent drugs in effective combinations and the development of standard multidrug therapy regimens have made a huge difference in the successful treatment of leprosy as well as in reducing tremendously the prevalence of leprosy globally. A major contributing factor to development of better drugs and drug combinations has been the introduction of the mouse footpad model to evaluate the in vivo activity of drugs against Mycobacterium leprae. The World Health Organization has recommended multidrug therapy, which has been used to treat more than 15 million patients in the last 30 years and has set an excellent record with regard to its very high rate of cure, very low occurrence of relapse, and very rare occurrence of drug resistance. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/26773621/History_of_chemotherapy_of_leprosy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-081X(15)00195-9 DB - PRIME DP - Unbound Medicine ER -