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Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia.
Vasc Med. 2016 Apr; 21(2):91-8.VM

Abstract

B-vitamin trials failed to demonstrate beneficial effects on cardiovascular outcomes, but hyperhomocysteinemia still stands out as an independent cardiovascular risk factor, particularly in elderly individuals. B-vitamins may influence early vascular dysfunction, such as endothelial dysfunction, or may have adverse effects, for example on inflammation. We investigated the effect of B-vitamins on endothelial function and inflammation within an interventional study. This study was conducted within the framework of the B-PROOF trial, which included 2919 hyperhomocysteinemic elderly individuals, who received daily vitamin B12 (500 μg) and folic acid (400 μg) or placebo for 2 years. Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo). Treatment effects were analyzed with ANCOVA. The participants had a mean age of 72 years, and 55% of them were male. At the 2-year follow-up, B-vitamins did not change the ICAM-1 (+36% change in the intervention group versus +32% change in the placebo group; p = 0.72), VCAM-1 (+27% vs +25%; p = 0.39), VEGF (-1% vs +4%; p = 0.40), SAA (+34% vs +38%; p = 0.85) or CRP levels (+26% vs +36%; p = 0.70) as compared to placebo. In conclusion, in elderly patients with hyperhomocysteinemia, vitamin B12 and folic acid are unlikely to influence either endothelial function or low-grade systemic inflammation. ClinicalTrials.gov Identifier: NCT00696514.

Authors+Show Affiliations

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands s.c.vandijk@erasmusmc.nl.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands.Department of Clinical Chemistry, Metabolic Unit, VU University Medical Center, Amsterdam, The Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands Netherlands Consortium for Healthy Ageing, Rotterdam, Leiden, The Netherlands.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands Department of Internal Medicine, Section of Geriatrics, Academic Medical Center, Amsterdam, The Netherlands.Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands Department of Internal Medicine and Institute for Cardiovascular Research ICaR-VU, VU University Medical Center, Amsterdam, The Netherlands.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26774115

Citation

van Dijk, Suzanne C., et al. "Effect of Vitamin B12 and Folic Acid Supplementation On Biomarkers of Endothelial Function and Inflammation Among Elderly Individuals With Hyperhomocysteinemia." Vascular Medicine (London, England), vol. 21, no. 2, 2016, pp. 91-8.
van Dijk SC, Enneman AW, Swart KM, et al. Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia. Vasc Med. 2016;21(2):91-8.
van Dijk, S. C., Enneman, A. W., Swart, K. M., van Wijngaarden, J. P., Ham, A. C., de Jonge, R., Blom, H. J., Feskens, E. J., Geleijnse, J. M., van Schoor, N. M., Dhonukshe-Rutten, R. A., de Jongh, R. T., Lips, P., de Groot, L. C., Uitterlinden, A. G., van den Meiracker, T. H., Mattace-Raso, F. U., van der Velde, N., & Smulders, Y. M. (2016). Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia. Vascular Medicine (London, England), 21(2), 91-8. https://doi.org/10.1177/1358863X15622281
van Dijk SC, et al. Effect of Vitamin B12 and Folic Acid Supplementation On Biomarkers of Endothelial Function and Inflammation Among Elderly Individuals With Hyperhomocysteinemia. Vasc Med. 2016;21(2):91-8. PubMed PMID: 26774115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia. AU - van Dijk,Suzanne C, AU - Enneman,Anke W, AU - Swart,Karin M A, AU - van Wijngaarden,Janneke P, AU - Ham,Annelies C, AU - de Jonge,R, AU - Blom,Henk J, AU - Feskens,Edith J, AU - Geleijnse,Johanna Marianne, AU - van Schoor,Natasja M, AU - Dhonukshe-Rutten,Rosalie A M, AU - de Jongh,Renate T, AU - Lips,Paul, AU - de Groot,Lisette C P G M, AU - Uitterlinden,Andre G, AU - van den Meiracker,Ton H, AU - Mattace-Raso,Francesco U S, AU - van der Velde,Nathalie, AU - Smulders,Yvo M, Y1 - 2016/01/15/ PY - 2016/1/17/entrez PY - 2016/1/17/pubmed PY - 2016/12/16/medline KW - B-PROOF KW - B-vitamins KW - Biomarkers KW - endothelial function KW - folic acid KW - homocysteine KW - inflammation SP - 91 EP - 8 JF - Vascular medicine (London, England) JO - Vasc Med VL - 21 IS - 2 N2 - B-vitamin trials failed to demonstrate beneficial effects on cardiovascular outcomes, but hyperhomocysteinemia still stands out as an independent cardiovascular risk factor, particularly in elderly individuals. B-vitamins may influence early vascular dysfunction, such as endothelial dysfunction, or may have adverse effects, for example on inflammation. We investigated the effect of B-vitamins on endothelial function and inflammation within an interventional study. This study was conducted within the framework of the B-PROOF trial, which included 2919 hyperhomocysteinemic elderly individuals, who received daily vitamin B12 (500 μg) and folic acid (400 μg) or placebo for 2 years. Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo). Treatment effects were analyzed with ANCOVA. The participants had a mean age of 72 years, and 55% of them were male. At the 2-year follow-up, B-vitamins did not change the ICAM-1 (+36% change in the intervention group versus +32% change in the placebo group; p = 0.72), VCAM-1 (+27% vs +25%; p = 0.39), VEGF (-1% vs +4%; p = 0.40), SAA (+34% vs +38%; p = 0.85) or CRP levels (+26% vs +36%; p = 0.70) as compared to placebo. In conclusion, in elderly patients with hyperhomocysteinemia, vitamin B12 and folic acid are unlikely to influence either endothelial function or low-grade systemic inflammation. ClinicalTrials.gov Identifier: NCT00696514. SN - 1477-0377 UR - https://www.unboundmedicine.com/medline/citation/26774115/Effect_of_vitamin_B12_and_folic_acid_supplementation_on_biomarkers_of_endothelial_function_and_inflammation_among_elderly_individuals_with_hyperhomocysteinemia_ L2 - https://journals.sagepub.com/doi/10.1177/1358863X15622281?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -