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Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency.
Turk J Med Sci 2015; 45(6):1280-4TJ

Abstract

BACKGROUND/AIM

The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body.

MATERIALS AND METHODS

Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods.

RESULTS

There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients.

CONCLUSION

These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

26775383

Citation

Güney, Tekin, et al. "Evaluation of Oxidant and Antioxidant Status in Patients With Vitamin B12 Deficiency." Turkish Journal of Medical Sciences, vol. 45, no. 6, 2015, pp. 1280-4.
Güney T, Alişik M, Akinci S, et al. Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. Turk J Med Sci. 2015;45(6):1280-4.
Güney, T., Alişik, M., Akinci, S., Neşelioğlu, S., Dilek, I., & Erel, O. (2015). Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. Turkish Journal of Medical Sciences, 45(6), pp. 1280-4.
Güney T, et al. Evaluation of Oxidant and Antioxidant Status in Patients With Vitamin B12 Deficiency. Turk J Med Sci. 2015;45(6):1280-4. PubMed PMID: 26775383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. AU - Güney,Tekin, AU - Alişik,Murat, AU - Akinci,Sema, AU - Neşelioğlu,Salim, AU - Dilek,Imdat, AU - Erel,Ozcan, PY - 2016/1/19/entrez PY - 2016/1/19/pubmed PY - 2016/2/19/medline SP - 1280 EP - 4 JF - Turkish journal of medical sciences JO - Turk J Med Sci VL - 45 IS - 6 N2 - BACKGROUND/AIM: The aim of this study was to examine the theory that oxidative stress might have an important mediating effect on the deleterious results of vitamin B12 metabolism deficiency seen throughout the body. MATERIALS AND METHODS: Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study. Venous blood samples were collected from all participants to evaluate serum vitamin B12, homocysteine, methylmalonic acid, total antioxidant status (TAS), and total oxidant status (TOS) levels in the pre- and posttreatment periods. RESULTS: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) levels between the pretreatment patient and control groups, and there were no significant differences in TAS or TOS levels between the posttreatment and control groups. In addition, there were no significant differences between the pre- and posttreatment TAS, TOS, and OSI levels of the patients. CONCLUSION: These findings are remarkable in that cyanocobalamin treatment had no direct effect on oxidant and antioxidant status in patients with vitamin B12 deficiency. The fact that there were no differences in oxidant and antioxidant status between the patients and the controls might suggest that oxidative stress does not play a role in the systemic negative effects of vitamin B12 deficiency. SN - 1300-0144 UR - https://www.unboundmedicine.com/medline/citation/26775383/Evaluation_of_oxidant_and_antioxidant_status_in_patients_with_vitamin_B12_deficiency_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -