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Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013.
Indian J Med Microbiol 2016 Jan-Mar; 34(1):88-91IJ

Abstract

BACKGROUND

Scrub typhus and leptospirosis are bacterial zoonotic disease causing high morbidity and mortality. The seasonal outbreak of pyrexia is common in Arunachal Pradesh (AP); many times the disease remains undiagnosed.

OBJECTIVE

An outbreak of pyrexia of unknown origin (PUO) occurred in Longding district of Arunachal Pradesh in 2013, with 108 deaths, which was investigated to elucidate the cause of illness.

METHODOLOGY

Blood samples from the affected region with acute pyrexia were collected, and screened for the malaria parasite, scrub typhus IgM and leptospira IgM.

RESULTS

Scrub typhus IgM was reactive in 97% (30/31), and 25% (8/31) cases were co-infected with leptospira. Incidentally, scrub typhus reactive (67%) and leptospira co-infection (62.7%) were higher in females. Record of previous 3 years (2011-2013) from Longding, Community Health Centre showed an increase in indoor pyrexia cases by 2-fold or more during October and November.

CONCLUSION

The present study is the first report of co-infection of scrub typhus with leptospirosis from Northeast India. Medical officers in this region should take scrub typhus and leptospirosis in their differential diagnosis of patients with PUO for early diagnosis and effective treatment.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableDepartment of Microbiology, Regional Medical Research Center, NE-Region, Dibrugarh, Assam, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26776126

Citation

Borkakoty, Biswajyoti, et al. "Co-infection of Scrub Typhus and Leptospirosis in Patients With Pyrexia of Unknown Origin in Longding District of Arunachal Pradesh in 2013." Indian Journal of Medical Microbiology, vol. 34, no. 1, 2016, pp. 88-91.
Borkakoty B, Jakharia A, Biswas D, et al. Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013. Indian J Med Microbiol. 2016;34(1):88-91.
Borkakoty, B., Jakharia, A., Biswas, D., & Mahanta, J. (2016). Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013. Indian Journal of Medical Microbiology, 34(1), pp. 88-91. doi:10.4103/0255-0857.174116.
Borkakoty B, et al. Co-infection of Scrub Typhus and Leptospirosis in Patients With Pyrexia of Unknown Origin in Longding District of Arunachal Pradesh in 2013. Indian J Med Microbiol. 2016;34(1):88-91. PubMed PMID: 26776126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013. AU - Borkakoty,Biswajyoti, AU - Jakharia,Aniruddha, AU - Biswas,Dipankar, AU - Mahanta,Jagadish, PY - 2016/1/19/entrez PY - 2016/1/19/pubmed PY - 2016/10/19/medline SP - 88 EP - 91 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 34 IS - 1 N2 - BACKGROUND: Scrub typhus and leptospirosis are bacterial zoonotic disease causing high morbidity and mortality. The seasonal outbreak of pyrexia is common in Arunachal Pradesh (AP); many times the disease remains undiagnosed. OBJECTIVE: An outbreak of pyrexia of unknown origin (PUO) occurred in Longding district of Arunachal Pradesh in 2013, with 108 deaths, which was investigated to elucidate the cause of illness. METHODOLOGY: Blood samples from the affected region with acute pyrexia were collected, and screened for the malaria parasite, scrub typhus IgM and leptospira IgM. RESULTS: Scrub typhus IgM was reactive in 97% (30/31), and 25% (8/31) cases were co-infected with leptospira. Incidentally, scrub typhus reactive (67%) and leptospira co-infection (62.7%) were higher in females. Record of previous 3 years (2011-2013) from Longding, Community Health Centre showed an increase in indoor pyrexia cases by 2-fold or more during October and November. CONCLUSION: The present study is the first report of co-infection of scrub typhus with leptospirosis from Northeast India. Medical officers in this region should take scrub typhus and leptospirosis in their differential diagnosis of patients with PUO for early diagnosis and effective treatment. SN - 1998-3646 UR - https://www.unboundmedicine.com/medline/citation/26776126/Co_infection_of_scrub_typhus_and_leptospirosis_in_patients_with_pyrexia_of_unknown_origin_in_Longding_district_of_Arunachal_Pradesh_in_2013_ L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2016;volume=34;issue=1;spage=88;epage=91;aulast=Borkakoty DB - PRIME DP - Unbound Medicine ER -