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The effect of statins on microalbuminuria, proteinuria, progression of kidney function, and all-cause mortality in patients with non-end stage chronic kidney disease: A meta-analysis.
Pharmacol Res. 2016 Mar; 105:74-83.PR

Abstract

Conclusive evidence regarding the effect of statins on non-end stage chronic kidney disease (CKD) has not been reported previously. This meta-analysis evaluated the association between statins and microalbuminuria, proteinuria, progression, and all-cause mortality in patients with non-end stage CKD. Databases (e.g., PubMed, Embase and the Cochrane Library) were searched for randomized controlled trials (RCTs) with data on statins, microalbuminuria, proteinuria, renal health endpoints, and all-cause mortality patients with non-end stage CKD to perform this meta-analysis. The mean difference (MD) of the urine albumin excretion ratios (UAER), 24-h urine protein excretion, and risk ratios (RR) of all-cause mortality and renal health endpoints were calculated, and the results are presented with 95% confidence intervals (CI). A total of 23 RCTs with 39,419 participants were selected. The analysis demonstrated that statins statistically reduced UAER to 26.73 μg/min [95%CI (-51.04, -2.43), Z=2.16, P<0.05], 24-h urine protein excretion to 682.68 mg [95%CI (-886.72, -478.63), Z=6.56, P<0.01] and decreased all-cause mortality [RR=0.78, 95%CI (0.72, 0.84), Z=6.08, P<0.01]. However, the analysis results did not indicate that statins reduced the events of renal health endpoints [RR=0.96, 95%CI (0.91,1.01), Z=1.40, P>0.05]. In summary, our study indicates that statins statistically reduced microalbuminuria, proteinuria, and clinical deaths, but statins did not effectively slow the clinical progression of non-end stage CKD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhang Z
Department of Cardiology, the Second People's Hospital of Foshan (the Affiliated Hospital at Foshan, Southern Medical University), Foshan, PR China. Electronic address: dede-308@163.com.
Wu P
Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, PR China. Electronic address: wupingsheng123@aliyun.com.
Zhang J
Department of Cardiology, the Second People's Hospital of Foshan (the Affiliated Hospital at Foshan, Southern Medical University), Foshan, PR China.
Wang S
Department of Cardiology, the Second People's Hospital of Foshan (the Affiliated Hospital at Foshan, Southern Medical University), Foshan, PR China.
Zhang G
Department of Cardiology, the Second People's Hospital of Foshan (the Affiliated Hospital at Foshan, Southern Medical University), Foshan, PR China.

MeSH

AlbuminuriaDisease ProgressionHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKidneyProteinuriaRenal Insufficiency, Chronic

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26776964

Citation

Zhang, Zhenhong, et al. "The Effect of Statins On Microalbuminuria, Proteinuria, Progression of Kidney Function, and All-cause Mortality in Patients With Non-end Stage Chronic Kidney Disease: a Meta-analysis." Pharmacological Research, vol. 105, 2016, pp. 74-83.
Zhang Z, Wu P, Zhang J, et al. The effect of statins on microalbuminuria, proteinuria, progression of kidney function, and all-cause mortality in patients with non-end stage chronic kidney disease: A meta-analysis. Pharmacol Res. 2016;105:74-83.
Zhang, Z., Wu, P., Zhang, J., Wang, S., & Zhang, G. (2016). The effect of statins on microalbuminuria, proteinuria, progression of kidney function, and all-cause mortality in patients with non-end stage chronic kidney disease: A meta-analysis. Pharmacological Research, 105, 74-83. https://doi.org/10.1016/j.phrs.2016.01.005
Zhang Z, et al. The Effect of Statins On Microalbuminuria, Proteinuria, Progression of Kidney Function, and All-cause Mortality in Patients With Non-end Stage Chronic Kidney Disease: a Meta-analysis. Pharmacol Res. 2016;105:74-83. PubMed PMID: 26776964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of statins on microalbuminuria, proteinuria, progression of kidney function, and all-cause mortality in patients with non-end stage chronic kidney disease: A meta-analysis. AU - Zhang,Zhenhong, AU - Wu,Pingsheng, AU - Zhang,Jiping, AU - Wang,Shunyin, AU - Zhang,Gengxin, Y1 - 2016/01/15/ PY - 2015/03/16/received PY - 2016/01/09/revised PY - 2016/01/10/accepted PY - 2016/1/19/entrez PY - 2016/1/19/pubmed PY - 2016/11/12/medline KW - All-cause mortality KW - Meta-analysis KW - Microalbuminuria KW - Non-end stage chronic kidney disease KW - Proteinuria KW - Statins SP - 74 EP - 83 JF - Pharmacological research JO - Pharmacol Res VL - 105 N2 - Conclusive evidence regarding the effect of statins on non-end stage chronic kidney disease (CKD) has not been reported previously. This meta-analysis evaluated the association between statins and microalbuminuria, proteinuria, progression, and all-cause mortality in patients with non-end stage CKD. Databases (e.g., PubMed, Embase and the Cochrane Library) were searched for randomized controlled trials (RCTs) with data on statins, microalbuminuria, proteinuria, renal health endpoints, and all-cause mortality patients with non-end stage CKD to perform this meta-analysis. The mean difference (MD) of the urine albumin excretion ratios (UAER), 24-h urine protein excretion, and risk ratios (RR) of all-cause mortality and renal health endpoints were calculated, and the results are presented with 95% confidence intervals (CI). A total of 23 RCTs with 39,419 participants were selected. The analysis demonstrated that statins statistically reduced UAER to 26.73 μg/min [95%CI (-51.04, -2.43), Z=2.16, P<0.05], 24-h urine protein excretion to 682.68 mg [95%CI (-886.72, -478.63), Z=6.56, P<0.01] and decreased all-cause mortality [RR=0.78, 95%CI (0.72, 0.84), Z=6.08, P<0.01]. However, the analysis results did not indicate that statins reduced the events of renal health endpoints [RR=0.96, 95%CI (0.91,1.01), Z=1.40, P>0.05]. In summary, our study indicates that statins statistically reduced microalbuminuria, proteinuria, and clinical deaths, but statins did not effectively slow the clinical progression of non-end stage CKD. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/26776964/The_effect_of_statins_on_microalbuminuria_proteinuria_progression_of_kidney_function_and_all_cause_mortality_in_patients_with_non_end_stage_chronic_kidney_disease:_A_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -