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Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action.
J Ethnopharmacol. 2016 Mar 02; 180:37-42.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Leaves infusion of Pimenta pseudocaryophyllus (Gomes) Landrum is used in Brazilian folk medicine to treat the predisposition to arthritical and gouty affections of the joints, fever and other diseases. A refreshing drink prepared with the specie is also used due to its diuretic, sedative and aphrodisiac actions.

AIM OF THE STUDY

The study was undertaken to investigate the mechanisms of anti-hyperuricemic effect and anti-inflammatory activity of P. pseudocaryophyllus extracts.

MATERIALS AND METHODS

Anti-hyperuricemic effect was investigated using xanthine oxidase assay and uricosuric studies with rats in which hyperuricemia was induced by potassium oxonate and uric acid. Anti-inflammatory activity was investigated on MSU crystal-induced paw edema model. Ethyl acetate extracts of the leaves (EAL) and branches (EAB), ethanolic extracts of leaves (EEL) and branches (EEB) and aqueous extracts of leaves (AL) and branches (AB) were evaluated.

RESULTS

The extracts of P. pseudocaryophyllus evaluated showed expressive results regarding the inhibition of xanthine oxidase enzyme in vitro and they were also able to reduce serum uric acid levels in hyperuricemic rats. The investigation of the mechanism of action, it was found that EAL, EAB, EEB, AB (125 and 250 mg/kg) and AL (250 mg/kg) promoted an increase on the urinary excretion of uric acid and EEL, EEB, AB (125 and 250 mg/kg) and EAB (250 mg/kg) were capable to inhibit liver xanthine oxidase. Treatments with EEL (125 and 250 mg/kg) and EEB (250 mg/kg) were able to reduce edema at 48 th h. EAL and EAB (125 and 250 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model at all evaluated times.

CONCLUSIONS

The specie P. pseudocaryophyllus showed remarkable anti-hyperuricemic effects through uricosuric effects and inhibition of xanthine oxidase and therefore can be considered as a promise in the treatment of diseases related to hyperuricemia. Moreover, ethyl acetate extracts had significant anti-inflammatory activity.

Authors+Show Affiliations

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil. Electronic address: saude@ef.ufop.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26778678

Citation

Ferrari, Fernanda Cristina, et al. "Effects of Pimenta Pseudocaryophyllus Extracts On Gout: Anti-inflammatory Activity and Anti-hyperuricemic Effect Through Xantine Oxidase and Uricosuric Action." Journal of Ethnopharmacology, vol. 180, 2016, pp. 37-42.
Ferrari FC, Lemos Lima Rde C, Schimith Ferraz Filha Z, et al. Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action. J Ethnopharmacol. 2016;180:37-42.
Ferrari, F. C., Lemos Lima, R. d. e. . C., Schimith Ferraz Filha, Z., Barros, C. H., de Paula Michel Araújo, M. C., & Antunes Saúde-Guimarães, D. (2016). Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action. Journal of Ethnopharmacology, 180, 37-42. https://doi.org/10.1016/j.jep.2016.01.007
Ferrari FC, et al. Effects of Pimenta Pseudocaryophyllus Extracts On Gout: Anti-inflammatory Activity and Anti-hyperuricemic Effect Through Xantine Oxidase and Uricosuric Action. J Ethnopharmacol. 2016 Mar 2;180:37-42. PubMed PMID: 26778678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action. AU - Ferrari,Fernanda Cristina, AU - Lemos Lima,Rita de Cássia, AU - Schimith Ferraz Filha,Zilma, AU - Barros,Camila Helena, AU - de Paula Michel Araújo,Marcela Carolina, AU - Antunes Saúde-Guimarães,Dênia, Y1 - 2016/01/08/ PY - 2015/10/07/received PY - 2015/12/31/revised PY - 2016/01/07/accepted PY - 2016/1/19/entrez PY - 2016/1/19/pubmed PY - 2016/12/15/medline KW - Gout KW - Hyperuricemia KW - Inflammation KW - Pimenta pseudocaryophyllus KW - Uricosuric KW - Xanthine oxidase SP - 37 EP - 42 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 180 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Leaves infusion of Pimenta pseudocaryophyllus (Gomes) Landrum is used in Brazilian folk medicine to treat the predisposition to arthritical and gouty affections of the joints, fever and other diseases. A refreshing drink prepared with the specie is also used due to its diuretic, sedative and aphrodisiac actions. AIM OF THE STUDY: The study was undertaken to investigate the mechanisms of anti-hyperuricemic effect and anti-inflammatory activity of P. pseudocaryophyllus extracts. MATERIALS AND METHODS: Anti-hyperuricemic effect was investigated using xanthine oxidase assay and uricosuric studies with rats in which hyperuricemia was induced by potassium oxonate and uric acid. Anti-inflammatory activity was investigated on MSU crystal-induced paw edema model. Ethyl acetate extracts of the leaves (EAL) and branches (EAB), ethanolic extracts of leaves (EEL) and branches (EEB) and aqueous extracts of leaves (AL) and branches (AB) were evaluated. RESULTS: The extracts of P. pseudocaryophyllus evaluated showed expressive results regarding the inhibition of xanthine oxidase enzyme in vitro and they were also able to reduce serum uric acid levels in hyperuricemic rats. The investigation of the mechanism of action, it was found that EAL, EAB, EEB, AB (125 and 250 mg/kg) and AL (250 mg/kg) promoted an increase on the urinary excretion of uric acid and EEL, EEB, AB (125 and 250 mg/kg) and EAB (250 mg/kg) were capable to inhibit liver xanthine oxidase. Treatments with EEL (125 and 250 mg/kg) and EEB (250 mg/kg) were able to reduce edema at 48 th h. EAL and EAB (125 and 250 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model at all evaluated times. CONCLUSIONS: The specie P. pseudocaryophyllus showed remarkable anti-hyperuricemic effects through uricosuric effects and inhibition of xanthine oxidase and therefore can be considered as a promise in the treatment of diseases related to hyperuricemia. Moreover, ethyl acetate extracts had significant anti-inflammatory activity. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/26778678/Effects_of_Pimenta_pseudocaryophyllus_extracts_on_gout:_Anti_inflammatory_activity_and_anti_hyperuricemic_effect_through_xantine_oxidase_and_uricosuric_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(16)30007-1 DB - PRIME DP - Unbound Medicine ER -