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Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice.
Inflammation. 2016 Apr; 39(2):752-8.I

Abstract

This study aimed to investigate the protective effects of apigenin against paraquat (PQ)-induced acute lung injury (ALI) in mice. Male Kunming mice were randomly divided into five groups: group 1 (control), group 2 (PQ), group 3 (PQ + apigenin 25 mg/kg), group 4 (PQ + apigenin 50 mg/kg), and group 5 (PQ + apigenin 100 mg/kg). The PQ + apigenin group received apigenin by gavage daily for consecutive 7 days, respectively, while the mice in control and PQ groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined using enzyme-linked immunosorbent assay (ELISA) kits. The activity of nuclear factor (NF)-κB was also determined. The results indicated that apigenin administration decreased biochemical parameters of inflammation and oxidative stress, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of apigenin were associated with inhibition of NF-κB. In conclusion, apigenin reduces PQ-induced ALI by inhibition of inflammation and oxidative stress.

Authors+Show Affiliations

Department of Pharmacy, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, China.Department of Radiology, Linyi People's Hospital, Linyi, 276000, China.Department of Emergency, Haiyang People's Hospital, No. 73 Haiyang Road, Haiyang, 265100, China. luanruiling@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26782361

Citation

Luan, Rui-Ling, et al. "Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice." Inflammation, vol. 39, no. 2, 2016, pp. 752-8.
Luan RL, Meng XX, Jiang W. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. Inflammation. 2016;39(2):752-8.
Luan, R. L., Meng, X. X., & Jiang, W. (2016). Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. Inflammation, 39(2), 752-8. https://doi.org/10.1007/s10753-015-0302-2
Luan RL, Meng XX, Jiang W. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. Inflammation. 2016;39(2):752-8. PubMed PMID: 26782361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. AU - Luan,Rui-Ling, AU - Meng,Xiang-Xi, AU - Jiang,Wei, PY - 2016/1/20/entrez PY - 2016/1/20/pubmed PY - 2017/1/11/medline KW - acute lung injury KW - apigenin KW - inflammation KW - oxidative stress KW - paraquat SP - 752 EP - 8 JF - Inflammation JO - Inflammation VL - 39 IS - 2 N2 - This study aimed to investigate the protective effects of apigenin against paraquat (PQ)-induced acute lung injury (ALI) in mice. Male Kunming mice were randomly divided into five groups: group 1 (control), group 2 (PQ), group 3 (PQ + apigenin 25 mg/kg), group 4 (PQ + apigenin 50 mg/kg), and group 5 (PQ + apigenin 100 mg/kg). The PQ + apigenin group received apigenin by gavage daily for consecutive 7 days, respectively, while the mice in control and PQ groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined using enzyme-linked immunosorbent assay (ELISA) kits. The activity of nuclear factor (NF)-κB was also determined. The results indicated that apigenin administration decreased biochemical parameters of inflammation and oxidative stress, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of apigenin were associated with inhibition of NF-κB. In conclusion, apigenin reduces PQ-induced ALI by inhibition of inflammation and oxidative stress. SN - 1573-2576 UR - https://www.unboundmedicine.com/medline/citation/26782361/Protective_Effects_of_Apigenin_Against_Paraquat_Induced_Acute_Lung_Injury_in_Mice_ L2 - https://doi.org/10.1007/s10753-015-0302-2 DB - PRIME DP - Unbound Medicine ER -