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Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients--relationship with plasma insulin.
Thromb Haemost. 1989 Jun 30; 61(3):370-3.TH

Abstract

Type 2 diabetic patients are known to frequently have a high insulin level and were recently described as having high plasminogen activator inhibitor (PAI) activity, compared to normal controls. As we have shown in several clinical conditions (normal subjects, obese patients, angina pectoris patients) that plasma PAI activity was linked with plasma insulin, we have studied in 38 type 2 diabetic patients the relationship between PAI activity, insulin and other parameters. Patients showed higher level of PAI activity, as well as plasma glucose, insulin, triglyceride, cholesterol and Apolipoprotein B levels than normal controls; highest values were observed with diabetic patients also affected by coronary artery disease. A significant correlation was found between PAI activity and insulin (r = 0.60, p less than 0.001), body mass index (r = 0.32, p less than 0.05) and Apolipoprotein B (r = 0.33, p less than 0.05). The two latter correlations disappeared after adjustment for insulin. These results are in agreement with our previous report showing an in vitro effect of insulin on the synthesis of PAI by a hepatocellular cell line. Hyperinsulinemia presented by type 2 diabetic patients may increase the hepatic synthesis of PAI, inducing an hypofibrinolysis, which could play a role in the development of the vascular complications. Attempts to reduce hyperinsulinemia could have a favorable effect by lowering PAI activity.

Authors+Show Affiliations

Laboratory of Haematology, CHU Timone, Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2678583

Citation

Juhan-Vague, I, et al. "Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients--relationship With Plasma Insulin." Thrombosis and Haemostasis, vol. 61, no. 3, 1989, pp. 370-3.
Juhan-Vague I, Roul C, Alessi MC, et al. Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients--relationship with plasma insulin. Thromb Haemost. 1989;61(3):370-3.
Juhan-Vague, I., Roul, C., Alessi, M. C., Ardissone, J. P., Heim, M., & Vague, P. (1989). Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients--relationship with plasma insulin. Thrombosis and Haemostasis, 61(3), 370-3.
Juhan-Vague I, et al. Increased Plasminogen Activator Inhibitor Activity in Non Insulin Dependent Diabetic Patients--relationship With Plasma Insulin. Thromb Haemost. 1989 Jun 30;61(3):370-3. PubMed PMID: 2678583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients--relationship with plasma insulin. AU - Juhan-Vague,I, AU - Roul,C, AU - Alessi,M C, AU - Ardissone,J P, AU - Heim,M, AU - Vague,P, PY - 1989/6/30/pubmed PY - 1989/6/30/medline PY - 1989/6/30/entrez SP - 370 EP - 3 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 61 IS - 3 N2 - Type 2 diabetic patients are known to frequently have a high insulin level and were recently described as having high plasminogen activator inhibitor (PAI) activity, compared to normal controls. As we have shown in several clinical conditions (normal subjects, obese patients, angina pectoris patients) that plasma PAI activity was linked with plasma insulin, we have studied in 38 type 2 diabetic patients the relationship between PAI activity, insulin and other parameters. Patients showed higher level of PAI activity, as well as plasma glucose, insulin, triglyceride, cholesterol and Apolipoprotein B levels than normal controls; highest values were observed with diabetic patients also affected by coronary artery disease. A significant correlation was found between PAI activity and insulin (r = 0.60, p less than 0.001), body mass index (r = 0.32, p less than 0.05) and Apolipoprotein B (r = 0.33, p less than 0.05). The two latter correlations disappeared after adjustment for insulin. These results are in agreement with our previous report showing an in vitro effect of insulin on the synthesis of PAI by a hepatocellular cell line. Hyperinsulinemia presented by type 2 diabetic patients may increase the hepatic synthesis of PAI, inducing an hypofibrinolysis, which could play a role in the development of the vascular complications. Attempts to reduce hyperinsulinemia could have a favorable effect by lowering PAI activity. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/2678583/Increased_plasminogen_activator_inhibitor_activity_in_non_insulin_dependent_diabetic_patients__relationship_with_plasma_insulin_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -