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Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China.
Vet Microbiol 2016; 183:85-91VM

Abstract

Pigs are susceptible to both human and avian influenza viruses and therefore have been proposed to be mixing vessels for the generation of pandemic influenza viruses through reassortment. In this study, for the first time, we report the isolation and genetic analyses of three novel triple-reassortant H1N1 swine influenza viruses from pigs in Tianjin, Northern China. Phylogenetic analysis showed that these novel viruses contained genes from the 2009 pandemic H1N1 (PB2, PB1, PA and NP), Eurasian swine (HA, NA and M) and triple-reassortant swine (NS) lineages. This indicated that the reassortment among the 2009 pandemic H1N1, Eurasian swine and triple-reassortant swine influenza viruses had taken place in pigs in Tianjin and resulted in the generation of new viruses. Furthermore, three human-like H1N1, two classical swine H1N1 and two Eurasian swine H1N1 viruses were also isolated during the swine influenza virus surveillance from 2009 to 2013, which indicated that multiple genetic lineages of swine H1N1 viruses were co-circulating in the swine population in Tianjin, China. The emergence of novel triple-reassortant H1N1 swine influenza viruses may be a potential threat to human health and emphasizes the importance of further continuous surveillance.

Authors+Show Affiliations

Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381,China. Electronic address: yanmh81971@126.com.Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China. Electronic address: haiyu_008@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26790939

Citation

Sun, Ying-Feng, et al. "Novel Triple-reassortant H1N1 Swine Influenza Viruses in Pigs in Tianjin, Northern China." Veterinary Microbiology, vol. 183, 2016, pp. 85-91.
Sun YF, Wang XH, Li XL, et al. Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China. Vet Microbiol. 2016;183:85-91.
Sun, Y. F., Wang, X. H., Li, X. L., Zhang, L., Li, H. H., Lu, C., ... Yu, H. (2016). Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China. Veterinary Microbiology, 183, pp. 85-91. doi:10.1016/j.vetmic.2015.12.006.
Sun YF, et al. Novel Triple-reassortant H1N1 Swine Influenza Viruses in Pigs in Tianjin, Northern China. Vet Microbiol. 2016 Feb 1;183:85-91. PubMed PMID: 26790939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China. AU - Sun,Ying-Feng, AU - Wang,Xiu-Hui, AU - Li,Xiu-Li, AU - Zhang,Li, AU - Li,Hai-Hua, AU - Lu,Chao, AU - Yang,Chun-Lei, AU - Feng,Jing, AU - Han,Wei, AU - Ren,Wei-Ke, AU - Tian,Xiang-Xue, AU - Tong,Guang-Zhi, AU - Wen,Feng, AU - Li,Ze-Jun, AU - Gong,Xiao-Qian, AU - Liu,Xiao-Min, AU - Ruan,Bao-Yang, AU - Yan,Ming-Hua, AU - Yu,Hai, Y1 - 2015/12/12/ PY - 2015/09/21/received PY - 2015/12/04/revised PY - 2015/12/10/accepted PY - 2016/1/22/entrez PY - 2016/1/23/pubmed PY - 2016/10/16/medline KW - Novel ressortant H1N1 influenza virus KW - Phylogenetic analysis KW - Swine influenza SP - 85 EP - 91 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 183 N2 - Pigs are susceptible to both human and avian influenza viruses and therefore have been proposed to be mixing vessels for the generation of pandemic influenza viruses through reassortment. In this study, for the first time, we report the isolation and genetic analyses of three novel triple-reassortant H1N1 swine influenza viruses from pigs in Tianjin, Northern China. Phylogenetic analysis showed that these novel viruses contained genes from the 2009 pandemic H1N1 (PB2, PB1, PA and NP), Eurasian swine (HA, NA and M) and triple-reassortant swine (NS) lineages. This indicated that the reassortment among the 2009 pandemic H1N1, Eurasian swine and triple-reassortant swine influenza viruses had taken place in pigs in Tianjin and resulted in the generation of new viruses. Furthermore, three human-like H1N1, two classical swine H1N1 and two Eurasian swine H1N1 viruses were also isolated during the swine influenza virus surveillance from 2009 to 2013, which indicated that multiple genetic lineages of swine H1N1 viruses were co-circulating in the swine population in Tianjin, China. The emergence of novel triple-reassortant H1N1 swine influenza viruses may be a potential threat to human health and emphasizes the importance of further continuous surveillance. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/26790939/Novel_triple_reassortant_H1N1_swine_influenza_viruses_in_pigs_in_Tianjin_Northern_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(15)30112-7 DB - PRIME DP - Unbound Medicine ER -