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Ethanol consumption during pregnancy in mice: effects on hormone concentrations.

Abstract

Hormonal and metabolic responses to ethanol consumption were studied in pregnant Swiss Webster mice and their fetuses. On day 10 of pregnancy, mice were assigned to one of three liquid diet groups: 36% ethanol-derived calories fed ad libitum (ETOH); control liquid diet fed ad libitum (control); control liquid diet administered in the same amount as that consumed by the ETOH group on the same day of pregnancy [pair-fed controls (PF)]. Dams were killed on days 14-18 of pregnancy, and fetuses were collected on days 16-18. Serum mouse placental lactogen-II (mPL-II), prolactin (mPRL), growth hormone (mGH), insulin, and glucose concentrations were determined for each group. Ethanol consumption resulted in a significant reduction in fetal weight on day 18 of pregnancy. The maternal serum mPRL concentration was reduced in ETOH mice on days 16 and 17 of pregnancy when compared with control mice, but when compared with PF mice, it was significantly reduced only on day 16. Maternal and fetal serum insulin concentrations were reduced in ETOH mice when compared with control mice, but it is unclear whether this was a specific effect of ethanol consumption or due to reduced food intake. Maternal serum glucose concentrations were reduced in the ETOH mice but not as severely as in the PF mice. Ethanol consumption had no effect on maternal or fetal serum mPL-II and mGH concentrations. These data confirm that ethanol consumption during pregnancy results in fetal growth retardation, but they do not indicate any major effects of ethanol on mPL-II, mPRL, mGH, and insulin concentrations in either the mother or fetus.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Biology Department, University of California, Santa Cruz 95064.

    , ,

    Source

    The American journal of physiology 257:4 Pt 1 1989 Oct pg E561-6

    MeSH

    Alcohol Drinking
    Animals
    Blood Glucose
    Body Weight
    Ethanol
    Female
    Fetal Blood
    Fetal Resorption
    Fetus
    Growth Hormone
    Insulin
    Litter Size
    Mice
    Placental Lactogen
    Pregnancy
    Pregnancy, Animal
    Prolactin
    Reference Values

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    2679130

    Citation

    Fielder, P J., et al. "Ethanol Consumption During Pregnancy in Mice: Effects On Hormone Concentrations." The American Journal of Physiology, vol. 257, no. 4 Pt 1, 1989, pp. E561-6.
    Fielder PJ, Robleto DO, Ogren L, et al. Ethanol consumption during pregnancy in mice: effects on hormone concentrations. Am J Physiol. 1989;257(4 Pt 1):E561-6.
    Fielder, P. J., Robleto, D. O., Ogren, L., & Talamantes, F. (1989). Ethanol consumption during pregnancy in mice: effects on hormone concentrations. The American Journal of Physiology, 257(4 Pt 1), pp. E561-6.
    Fielder PJ, et al. Ethanol Consumption During Pregnancy in Mice: Effects On Hormone Concentrations. Am J Physiol. 1989;257(4 Pt 1):E561-6. PubMed PMID: 2679130.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ethanol consumption during pregnancy in mice: effects on hormone concentrations. AU - Fielder,P J, AU - Robleto,D O, AU - Ogren,L, AU - Talamantes,F, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - E561 EP - 6 JF - The American journal of physiology JO - Am. J. Physiol. VL - 257 IS - 4 Pt 1 N2 - Hormonal and metabolic responses to ethanol consumption were studied in pregnant Swiss Webster mice and their fetuses. On day 10 of pregnancy, mice were assigned to one of three liquid diet groups: 36% ethanol-derived calories fed ad libitum (ETOH); control liquid diet fed ad libitum (control); control liquid diet administered in the same amount as that consumed by the ETOH group on the same day of pregnancy [pair-fed controls (PF)]. Dams were killed on days 14-18 of pregnancy, and fetuses were collected on days 16-18. Serum mouse placental lactogen-II (mPL-II), prolactin (mPRL), growth hormone (mGH), insulin, and glucose concentrations were determined for each group. Ethanol consumption resulted in a significant reduction in fetal weight on day 18 of pregnancy. The maternal serum mPRL concentration was reduced in ETOH mice on days 16 and 17 of pregnancy when compared with control mice, but when compared with PF mice, it was significantly reduced only on day 16. Maternal and fetal serum insulin concentrations were reduced in ETOH mice when compared with control mice, but it is unclear whether this was a specific effect of ethanol consumption or due to reduced food intake. Maternal serum glucose concentrations were reduced in the ETOH mice but not as severely as in the PF mice. Ethanol consumption had no effect on maternal or fetal serum mPL-II and mGH concentrations. These data confirm that ethanol consumption during pregnancy results in fetal growth retardation, but they do not indicate any major effects of ethanol on mPL-II, mPRL, mGH, and insulin concentrations in either the mother or fetus. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/2679130/Ethanol_consumption_during_pregnancy_in_mice:_effects_on_hormone_concentrations_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.1989.257.4.E561?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -