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Ethanol consumption during pregnancy in mice: effects on hormone concentrations.
Am J Physiol 1989; 257(4 Pt 1):E561-6AJ

Abstract

Hormonal and metabolic responses to ethanol consumption were studied in pregnant Swiss Webster mice and their fetuses. On day 10 of pregnancy, mice were assigned to one of three liquid diet groups: 36% ethanol-derived calories fed ad libitum (ETOH); control liquid diet fed ad libitum (control); control liquid diet administered in the same amount as that consumed by the ETOH group on the same day of pregnancy [pair-fed controls (PF)]. Dams were killed on days 14-18 of pregnancy, and fetuses were collected on days 16-18. Serum mouse placental lactogen-II (mPL-II), prolactin (mPRL), growth hormone (mGH), insulin, and glucose concentrations were determined for each group. Ethanol consumption resulted in a significant reduction in fetal weight on day 18 of pregnancy. The maternal serum mPRL concentration was reduced in ETOH mice on days 16 and 17 of pregnancy when compared with control mice, but when compared with PF mice, it was significantly reduced only on day 16. Maternal and fetal serum insulin concentrations were reduced in ETOH mice when compared with control mice, but it is unclear whether this was a specific effect of ethanol consumption or due to reduced food intake. Maternal serum glucose concentrations were reduced in the ETOH mice but not as severely as in the PF mice. Ethanol consumption had no effect on maternal or fetal serum mPL-II and mGH concentrations. These data confirm that ethanol consumption during pregnancy results in fetal growth retardation, but they do not indicate any major effects of ethanol on mPL-II, mPRL, mGH, and insulin concentrations in either the mother or fetus.

Authors+Show Affiliations

Biology Department, University of California, Santa Cruz 95064.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2679130

Citation

Fielder, P J., et al. "Ethanol Consumption During Pregnancy in Mice: Effects On Hormone Concentrations." The American Journal of Physiology, vol. 257, no. 4 Pt 1, 1989, pp. E561-6.
Fielder PJ, Robleto DO, Ogren L, et al. Ethanol consumption during pregnancy in mice: effects on hormone concentrations. Am J Physiol. 1989;257(4 Pt 1):E561-6.
Fielder, P. J., Robleto, D. O., Ogren, L., & Talamantes, F. (1989). Ethanol consumption during pregnancy in mice: effects on hormone concentrations. The American Journal of Physiology, 257(4 Pt 1), pp. E561-6.
Fielder PJ, et al. Ethanol Consumption During Pregnancy in Mice: Effects On Hormone Concentrations. Am J Physiol. 1989;257(4 Pt 1):E561-6. PubMed PMID: 2679130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol consumption during pregnancy in mice: effects on hormone concentrations. AU - Fielder,P J, AU - Robleto,D O, AU - Ogren,L, AU - Talamantes,F, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - E561 EP - 6 JF - The American journal of physiology JO - Am. J. Physiol. VL - 257 IS - 4 Pt 1 N2 - Hormonal and metabolic responses to ethanol consumption were studied in pregnant Swiss Webster mice and their fetuses. On day 10 of pregnancy, mice were assigned to one of three liquid diet groups: 36% ethanol-derived calories fed ad libitum (ETOH); control liquid diet fed ad libitum (control); control liquid diet administered in the same amount as that consumed by the ETOH group on the same day of pregnancy [pair-fed controls (PF)]. Dams were killed on days 14-18 of pregnancy, and fetuses were collected on days 16-18. Serum mouse placental lactogen-II (mPL-II), prolactin (mPRL), growth hormone (mGH), insulin, and glucose concentrations were determined for each group. Ethanol consumption resulted in a significant reduction in fetal weight on day 18 of pregnancy. The maternal serum mPRL concentration was reduced in ETOH mice on days 16 and 17 of pregnancy when compared with control mice, but when compared with PF mice, it was significantly reduced only on day 16. Maternal and fetal serum insulin concentrations were reduced in ETOH mice when compared with control mice, but it is unclear whether this was a specific effect of ethanol consumption or due to reduced food intake. Maternal serum glucose concentrations were reduced in the ETOH mice but not as severely as in the PF mice. Ethanol consumption had no effect on maternal or fetal serum mPL-II and mGH concentrations. These data confirm that ethanol consumption during pregnancy results in fetal growth retardation, but they do not indicate any major effects of ethanol on mPL-II, mPRL, mGH, and insulin concentrations in either the mother or fetus. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/2679130/Ethanol_consumption_during_pregnancy_in_mice:_effects_on_hormone_concentrations_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.1989.257.4.E561?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -