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DIVALENT CATIONS PROFILE IN PATIENTS WITH LIVER CIRRHOSIS AND VARICEAL BLEEDING.
Rev Med Chir Soc Med Nat Iasi 2015 Oct-Dec; 119(4):1166-73RM

Abstract

AIM

The objective of this study is to evaluate divalent cations serum levels (magnesium, zinc, copper) in liver cirrhossis and one of its major complication (variceal bleeding).

MATERIAL AND METHODS

A prospective case-control study including 60 patients with liver cirrhosis complicated with variceal bleeding admitted to the Emergency Department, and 35 subjects without liver cirrhosis which served as group control. Serum concentrations of zinc, copper and magnesium were determined using atomic absorption spectrophotometer.

RESULTS

The concentration of magnesium was significantly lower between patients with liver cirrhosis (11.6 ± 2.77mg/l) vs group control study (17.7 = 3.86 mg/l) (p < 0.001), regarding decreased magnesium levels and the presence of complications as hepatic encephalopathy, ascites (Child C class). Serum concentrations of zinc were decreased (0.77 ± 0.35 mg/l) compared to control group (p < 0.001) in patients with liver cirrhosis and variceal bleeding. Serum levels of copper were increased (1.69 ± 0.722 mg/l) compared to control group in patients with liver cirrhosis and variceal bleeding and are also correlated with serum albumin levels (p < 0.001, Pearson coefficient r-0.631).

CONCLUSIONS

Variceal bleeding in patients with liver cirrhosis is associated to important imbalances in blood concentrations of zinc, copper and magnesium.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26793865

Citation

Dumea, Mihaela, et al. "DIVALENT CATIONS PROFILE in PATIENTS WITH LIVER CIRRHOSIS and VARICEAL BLEEDING." Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, vol. 119, no. 4, 2015, pp. 1166-73.
Dumea M, Cimpoesu DC, Nechifor M. DIVALENT CATIONS PROFILE IN PATIENTS WITH LIVER CIRRHOSIS AND VARICEAL BLEEDING. Rev Med Chir Soc Med Nat Iasi. 2015;119(4):1166-73.
Dumea, M., Cimpoesu, D. C., & Nechifor, M. (2015). DIVALENT CATIONS PROFILE IN PATIENTS WITH LIVER CIRRHOSIS AND VARICEAL BLEEDING. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, 119(4), pp. 1166-73.
Dumea M, Cimpoesu DC, Nechifor M. DIVALENT CATIONS PROFILE in PATIENTS WITH LIVER CIRRHOSIS and VARICEAL BLEEDING. Rev Med Chir Soc Med Nat Iasi. 2015;119(4):1166-73. PubMed PMID: 26793865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DIVALENT CATIONS PROFILE IN PATIENTS WITH LIVER CIRRHOSIS AND VARICEAL BLEEDING. AU - Dumea,Mihaela, AU - Cimpoesu,Diana Carmen, AU - Nechifor,M, PY - 2016/1/23/entrez PY - 2016/1/23/pubmed PY - 2016/3/29/medline SP - 1166 EP - 73 JF - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi JO - Rev Med Chir Soc Med Nat Iasi VL - 119 IS - 4 N2 - AIM: The objective of this study is to evaluate divalent cations serum levels (magnesium, zinc, copper) in liver cirrhossis and one of its major complication (variceal bleeding). MATERIAL AND METHODS: A prospective case-control study including 60 patients with liver cirrhosis complicated with variceal bleeding admitted to the Emergency Department, and 35 subjects without liver cirrhosis which served as group control. Serum concentrations of zinc, copper and magnesium were determined using atomic absorption spectrophotometer. RESULTS: The concentration of magnesium was significantly lower between patients with liver cirrhosis (11.6 ± 2.77mg/l) vs group control study (17.7 = 3.86 mg/l) (p < 0.001), regarding decreased magnesium levels and the presence of complications as hepatic encephalopathy, ascites (Child C class). Serum concentrations of zinc were decreased (0.77 ± 0.35 mg/l) compared to control group (p < 0.001) in patients with liver cirrhosis and variceal bleeding. Serum levels of copper were increased (1.69 ± 0.722 mg/l) compared to control group in patients with liver cirrhosis and variceal bleeding and are also correlated with serum albumin levels (p < 0.001, Pearson coefficient r-0.631). CONCLUSIONS: Variceal bleeding in patients with liver cirrhosis is associated to important imbalances in blood concentrations of zinc, copper and magnesium. SN - 0048-7848 UR - https://www.unboundmedicine.com/medline/citation/26793865/DIVALENT_CATIONS_PROFILE_IN_PATIENTS_WITH_LIVER_CIRRHOSIS_AND_VARICEAL_BLEEDING_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -