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[Prevention of stomatitis induced by anti-cancer drugs].
Gan To Kagaku Ryoho. 1989 Oct; 16(10):3449-51.GT

Abstract

A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.

Authors+Show Affiliations

Dept. of Gynecology, Faculty of Medicine, Kagoshima University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

jpn

PubMed ID

2679397

Citation

Dozono, H, et al. "[Prevention of Stomatitis Induced By Anti-cancer Drugs]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 16, no. 10, 1989, pp. 3449-51.
Dozono H, Nakamura K, Motoya T, et al. [Prevention of stomatitis induced by anti-cancer drugs]. Gan To Kagaku Ryoho. 1989;16(10):3449-51.
Dozono, H., Nakamura, K., Motoya, T., Nakamura, S., Shinmura, R., Miwa, K., Ishibashi, M., & Nagata, Y. (1989). [Prevention of stomatitis induced by anti-cancer drugs]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 16(10), 3449-51.
Dozono H, et al. [Prevention of Stomatitis Induced By Anti-cancer Drugs]. Gan To Kagaku Ryoho. 1989;16(10):3449-51. PubMed PMID: 2679397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevention of stomatitis induced by anti-cancer drugs]. AU - Dozono,H, AU - Nakamura,K, AU - Motoya,T, AU - Nakamura,S, AU - Shinmura,R, AU - Miwa,K, AU - Ishibashi,M, AU - Nagata,Y, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 3449 EP - 51 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 16 IS - 10 N2 - A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/2679397/[Prevention_of_stomatitis_induced_by_anti_cancer_drugs]_ DB - PRIME DP - Unbound Medicine ER -